GEO DataSets

(Submitter supplied) A functional placental barrier is crucial for the supply of the embryo or foetus throughout pregnancy. It is formed by the syncytiotrophoblast, which develops via fusion of cytotrophoblast cells. How this “differentiation-by-fusion” is regulated is only partially understood. Here we analysed transcriptome changes during in vitro cytotrophoblast fusion. Pathway analyses yielded the tumor suppressor p53 as upstream negative regulator and indicated an upregulation of autophagy-related genes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

6 Samples

Download data: TXT

(Submitter supplied) Ror2 is a member of the Ror-family of receptor tyrosine kinases acting as a receptor for Wnt5a. Wnt5a/Ror2 signaling activates primarily the ß-catenin-independent pathway, which involves various signal mediators, such as Dishevelled, c-Jun N-terminal kinase (JNK), filamin A, c-Src, and Ca2+. Wnt5a/Ror2 signaling has also been shown to inhibit the ß-catenin-dependent pathway. Wnt5a and Ror2 are overexpressed in various types of tumor cells, including osteosarcoma and melanoma cells, resulting in constitutive activation of Wnt5a/Ror2 signaling in a cell-autonomous manner. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

4 Samples

Download data: TXT

(Submitter supplied) Background: Cervical lymph node metastasis is a potent prognostic factor in oral squamous cell carcinoma (OSCC). However, lymph nodes resected by sentinel node biopsy or neck dissection are usually diagnosed by examining only one or two sections of the maximal cut surface. Accurate diagnosis of the metastasis in lymph nodes is important but depends on a heavy workload of the pathologist. In this study, we have attempted to identify novel molecular markers to find the harboring cancer cells in the lymph node and establish rapid detection method. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

13 Samples

Download data: TXT

(Submitter supplied) No consensus treatment regime exists beyond surgery for malignant peripheral nerve sheath tumours (MPNST), and the purpose of the present study was to find new approaches to stratify patients with good and poor prognosis and to better guide therapeutic intervention for this aggressive soft tissue cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

38 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of hPTTG1-/- HCT116 human colorectal cancer cells comparing hPTTG1-/- HCT116 cells transfected with pcDNA3.1, and with hPTTG1-/- HCT116 cells transfected with pcDNA3.1-hPTTG1 plasmid.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

3 Samples

Download data: TXT

(Submitter supplied) Purpose: The majority of patients with epithelial ovarian cancer (EOC) is diagnosed at advanced stage and has a poor prognosis. A proportion of these patients though will fare well, with a prognosis similar to patients with early stage disease while others die very quickly. Clinicopathological prognostic factors do not allow precise identification of these subgroups. Thus we have validated a molecular subclassification as prognostic factor in EOC. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

204 Samples

Download data: TXT

(Submitter supplied) Robust genes were up-regulated in the oral cancer cells with SDF-1/CXCR4 system; however, most of the genes did not exhibit metastasis-related functions.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

2 Samples

Download data: TXT

(Submitter supplied) Osteosarcoma is a rare but aggressive bone neoplasm in humans, which is commonly treated with surgery, classical chemotherapy and radiation. Here, we studied the antimetastatic potential of 4 μM of the multikinase inhibitor Sorafenib in a human osteosarcoma cell line using DNA microarray-based gene expression profiling.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

6 Samples

Download data: TXT

(Submitter supplied) Glioblastoma, the most common and malignant brain tumor, harbors stem-like cells that self-renew and propagate upon serial transplantation. Although they share functional, morphological and developmental similarities to adult brain neural stem cells, stem cell characteristic pathways contributing to glioblastoma stem-like cells have not been consistently determined. Towards this goal we have provided an internally coherent molecular reference that compares adult neural and glioblastoma stem cells cultivated under identical conditions. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

14 Samples

Download data: TXT

(Submitter supplied) We used DNA microarray technology to assess changes in gene expression after treatment of 11 lymphoma cell lines with epigenetic drugs. We identified genes with upregulated expression in treated cell lines and with downregulated expression in B-cell lymphoma patient samples when compared to normal B cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

22 Samples

Download data: TXT

(Submitter supplied) Common overexpressing genes were identified in all human oral squamous cell carcinoma tissues and/or cultured cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL2986 GPL1426

24 Samples

Download data: TXT

(Submitter supplied) In attempt to understand M.leprae interaction with the human host, Applied Biosystems microarrays containing 30,865 probles were used to identify modulated genes in primary human Schwann Cells (SC) infected with live M. leprae at two early time points, 24 and 48 hours.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

8 Samples

Download data: TXT

(Submitter supplied) Colorectal cancer (CRC) incidence increases with age and early onset of the disease is an indication of genetic predisposition, estimated to cause up to 30 % of all CRC cases. To identify genes associated with an increased risk for CRC, genome-wide gene expression levels of CRCs from patients diagnosed at an early age and CRCs from patients diagnosed at higher age were investigated. Patients with known hereditary predisposition syndromes were excluded from the study.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5232

Platform:

GPL2986

50 Samples

Download data: TXT

(Submitter supplied) Objective: The immune system is a key player in fighting cancer. Thus, we seeked to identify a molecular ‘immune response signature’ indicating the presence of epithelial ovarian cancer (EOC) and to combine this with a serum protein biomarker panel to increase the specificity and sensitivity for earlier detection of EOC. Methods: Comparing the expression of 32,000 genes in a leukocytes fraction from 48 EOC patients and 20 controls, three uncorrelated shrunken centroid models were selected, comprised of 7, 14, and 6 genes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

68 Samples

Download data: TXT

(Submitter supplied) Tet-on and tet-off systems are among the most popular vector systems for inducible transgene expression in mammalian cells. In tet-regulated systems the expression of the transgene depends on the presence or absence of the antibiotic tetracycline or its derivative doxycycline, which are added to the cell culture medium in concentrations considered to be far below cytotoxic levels. Therefore, potential effects on the treated cells, which are exerted by the antibiotic itself and unrelated to transgene expression, are often ignored. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

4 Samples

Download data: TXT

(Submitter supplied) The human placenta is a rapidly developing organ with a relatively short life span that performs multiple functions until birth. Investigations into molecular mechanisms that control placental plasticity during its maturation might be useful in understanding patho-physiology of pregnancy-specific disorders. We hypothesized that molecular rearrangements and phenotypic adaptations that are necessary for normal placental development and maturation are reflected in its genotype. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

37 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL2986 GPL570

10 Samples

Download data: TXT

(Submitter supplied) Angiogenesis and lymphangiogenesis have important roles in cancer progression and inflammatory diseases, but it has been a challenge to evaluate theses processes quantitatively. Using two different microarray platforms, we first identified the comprehensive lineage specific transcriptomes of human lymphatic (LEC) and blood vascular (BVEC) endothelial cells. We identified 226 lymphatic signature genes and 342 signature genes for blood vascular endothelium. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL2986 GPL570

8 Samples

Download data: TXT

(Submitter supplied) Angiogenesis and lymphangiogenesis have important roles in cancer progression and chronic inflammatory diseases, but efficient therapies against these diseases have been hampered by the lack of identified vascular lineage-specific markers and growth factors. Using transcriptional profiling of matched pairs of human dermal blood vascular and lymphatic endothelial cells, we first identified 236 lymphatic and 342 blood vascular signature genes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

6 Samples

Download data: TXT

(Submitter supplied) 10 biopsies from one patient undergoing a auxiliary liver and combined kidney transplantation, where one liver lobe is replaced by an auxiliary liver lobe. Thereafter the kidney is transplanted. Keywords: Time course study

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2986

10 Samples

Download data: TXT