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Links from GEO DataSets

Items: 8

1.

Theca cell gene expression

(Submitter supplied) Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that affects 5-10% of reproductive aged women. The hallmark characteristic of PCOS is increased ovarian androgen synthesis. Previous studies by our laboratory demonstrated that increased androgen synthesis is a stable biochemical phenotype of PCOS theca cells which are the primary source of ovarian androgen production. The increase in theca cell steroidogenesis was due to an increase in expression of several steroidogenic enzymes including CYP17 and CYP11A but not StAR. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS1050 GDS1051
Platforms:
GPL96 GPL97
26 Samples
Download data: CEL, EXP
Series
Accession:
GSE1615
ID:
200001615
2.
Full record GDS1051

Valproic acid effect on theca cells (HG-U133B)

Analysis of normal theca cells treated with 500 uM valproic acid (VPA), an anti-epilipetic that induces polycystic ovary syndrome (PCOS)-like symptoms. Theca cells from PCOS patients also examined. Results provide insight into the underlying mechanisms contributing to VPA-induced PCOS-like symptoms.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 disease state sets
Platform:
GPL97
Series:
GSE1615
13 Samples
Download data: CEL, EXP
DataSet
Accession:
GDS1051
ID:
1051
3.
Full record GDS1050

Valproic acid effect on theca cells (HG-U133A)

Analysis of normal theca cells treated with 500 uM valproic acid (VPA), an anti-epilipetic that induces polycystic ovary syndrome (PCOS)-like symptoms. Theca cells from PCOS patients also examined. Results provide insight into the underlying mechanisms contributing to VPA-induced PCOS-like symptoms.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 disease state sets
Platform:
GPL96
Series:
GSE1615
13 Samples
Download data: CEL, EXP
DataSet
Accession:
GDS1050
ID:
1050
4.

Reduced expression of mitochondrial oxidative metabolism genes in skeletal muscle of women with PCOS

(Submitter supplied) Recently, abnormalities in mitochondrial oxidative phosphorylation (OXPHOS) have been implicated in the pathogenesis of skeletal muscle insulin resistance in type 2 diabetes. In the present study, we hypothesized that decreased expression of OXPHOS genes could be of similar importance for insulin resistance in the polycystic ovary syndrome (PCOS). Using the HG-U133 Plus 2.0 expression array from Affymetrix, we analyzed gene expression in skeletal muscle from obese women with PCOS (n=16) and age- and body mass index-matched control women (n=13) metabolically characterized by euglycemic-hyperinsulinemic clamp and indirect calorimetry. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3104
Platform:
GPL570
29 Samples
Download data: CEL
Series
Accession:
GSE6798
ID:
200006798
5.
Full record GDS3104

Insulin-resistant polycystic ovary syndrome: muscle

Analysis of vastus lateralis muscles from women with insulin-resistant polycystic ovary syndrome (PCOS). Insulin resistance in skeletal muscles is a risk factor for the development of type 2 diabetes in women with PCOS. Results provide insight into the pathogenesis of insulin resistance in PCOS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL570
Series:
GSE6798
29 Samples
Download data: CEL
DataSet
Accession:
GDS3104
ID:
3104
6.

Gene expression microarray profiles of cumulus cells in lean and overweight-obese polycystic ovary syndrome patients

(Submitter supplied) Objective: The etiology of PCOS is mostly unknown. Existing data support both genetic and environmental factors in its pathogenesis. Design: Prospective case - control study. Setting: University Hospital. Patients: 25 patients undergoing IVF-ICSI treatment. Intervention: Genome-wide oligonucleotide microarray technology was used to study differential gene-expression patterns of cultured human cumulus cells from IVF patients divided into 4 groups according to disease state (PCOS vs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3841
Platform:
GPL570
23 Samples
Download data: CEL
Series
Accession:
GSE10946
ID:
200010946
7.
Full record GDS3841

Lean and overweight-obese polycystic ovary syndrome patients: cultured cumulus cells

Analysis of cumulus cells from lean and overweight-obese polycystic ovary syndrome (PCOS) patients undergoing in vitro fertilization (IVF). PCOS is a heterogeneous endocrinopathy in women of reproductive age, mostly associated with ovulation failure. Results provide insight into PCOS pathogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state, 2 other sets
Platform:
GPL570
Series:
GSE10946
23 Samples
Download data: CEL
DataSet
Accession:
GDS3841
ID:
3841
8.

Microarray analysis of NL and PCOS oocytes

(Submitter supplied) Polycystic ovary syndrome (PCOS), the most common cause of anovulatory infertility, is characterized by increased ovarian androgen production, arrested follicle development, and is frequently associated with insulin resistance. These PCOS phenotypes are associated with exaggerated ovarian responsiveness to FSH and increased pregnancy loss. To examine whether the perturbations in follicle growth and the intrafollicular environment affects development of the mature PCOS oocyte, genes that are differentially expressed in PCOS compared to normal oocytes were defined using microarray analysis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
12 Samples
Download data: CEL, EXP
Series
Accession:
GSE5850
ID:
200005850
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