Similar studies for GEO DataSets (Select 200037030) - GEO DataSets

Select item 2000370301.

Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL1261 GPL6246
26 Samples

Download data: CEL

Series

Accession:: GSE37030

ID:: 200037030

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000375662.

Dendritic cell and monocyte progenitors

(Submitter supplied) To compare the gene expression profiles of Macrophage & Dendritic cell Progenitors (MDPs), Common Dendritic cell Progenitors (CDPs), committed dendritic cell precursors (pre-DCs), and Ly6Chi monocytes from mouse bone marrow

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
12 Samples

Download data: CEL

Series

Accession:: GSE37566

ID:: 200037566

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001897803.

Plasmacytoid dendritic cell precursors give rise to conventional dendritic cells via a Siglec-H+ Zbtb46+ Ly6D+ intermediary stage

(Submitter supplied) Plasmacytoid and conventional dendritic cells (pDC, and cDC) are generated from distinct lymphoid and myeloid progenitor cells in murine bone marrow. Despite the early separation of pDC and cDC lineages, CD11c+ MHCII-/lo Siglec-H+ CCR9lo pDC-like precursor cells are able to differentiate into both pDC and cDC. Single-cell transcriptomics and high-dimensional flow cytometry combined with cell fate analysis revealed the heterogeneity and commitment of subsets in this compartment. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18480
12 Samples

Download data: TXT

Series

Accession:: GSE189780

ID:: 200189780

PubMed Full text in PMC Similar studies

Select item 2000379954.

zDC (Zbtb46, Btbd4) knockout classical dendritic cells

(Submitter supplied) Classical dendritic cells (cDCs) process and present antigens to T cells. Under steady-state conditions, antigen presentation by cDCs induces tolerance. In contrast, during infection or inflammation, cDCs become activated, express higher levels of cell surface MHC molecules, and induce strong adaptive immune responses. We recently identified a cDC-restricted zinc finger transcription factor, zDC, that is not expressed by other immune cell populations, including pDCs, monocytes, or macrophages. more...

Organism:: Mus musculus

Type:: Expression profiling by array; Third-party reanalysis

Platform:: GPL1261
6 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE37995

ID:: 200037995

PubMed Full text in PMC Similar studies

Select item 2000750155.

Distinct transcriptional programs control cross-presentation in classical- and monocyte-derived dendritic cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
16 Samples

Download data: CEL

Series

Accession:: GSE75015

ID:: 200075015

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000750146.

Microarray expression data from WT and IRF4 KO Sirp-a+ DCs

(Submitter supplied) Cross-presentation of cell-associated antigens is carried out by classical DCs (cDCs) and monocyte-derived DCs (Mo-DCs), but whether a similar or distinct program exists for this process is unknown. In examining this issue, we discovered that only Ly-6ChiTremL4– monocytes, but not Ly-6ChiTremL4+ monocytes, can differentiate into Zbtb46+ Mo-DCs in response to GM-CSF and IL-4. However, Ly-6ChiTremL4+ monocytes were committed to Nur77-dependent development of Ly-6CloTremL4+ monocytes. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
4 Samples

Download data: CEL

Series

Accession:: GSE75014

ID:: 200075014

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000750137.

Microarray expression data from circulating blood monocytes

(Submitter supplied) Cross-presentation of cell-associated antigens is carried out by classical DCs (cDCs) and monocyte-derived DCs (Mo-DCs), but whether a similar or distinct program exists for this process is unknown. In examining this issue, we discovered that only Ly-6ChiTremL4– monocytes, but not Ly-6ChiTremL4+ monocytes, can differentiate into Zbtb46+ Mo-DCs in response to GM-CSF and IL-4. However, Ly-6ChiTremL4+ monocytes were committed to Nur77-dependent development of Ly-6CloTremL4+ monocytes. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
3 Samples

Download data: CEL

Series

Accession:: GSE75013

ID:: 200075013

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000750128.

Microarray expression data from monocytes, Mo-DCs and CD24 DCs

(Submitter supplied) Cross-presentation of cell-associated antigens is carried out by classical DCs (cDCs) and monocyte-derived DCs (Mo-DCs), but whether a similar or distinct program exists for this process is unknown. In examining this issue, we discovered that only Ly-6ChiTremL4– monocytes, but not Ly-6ChiTremL4+ monocytes, can differentiate into Zbtb46+ Mo-DCs in response to GM-CSF and IL-4. However, Ly-6ChiTremL4+ monocytes were committed to Nur77-dependent development of Ly-6CloTremL4+ monocytes. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
9 Samples

Download data: CEL

Series

Accession:: GSE75012

ID:: 200075012

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000439639.

Mtg16 regulates E protein activity and lineage specification in dendritic cell development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL6246
5 Samples

Download data: BED, CEL

Series

Accession:: GSE43963

ID:: 200043963

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004387610.

Mtg16 regulates E protein activity and lineage specification in dendritic cell development (ChIP-seq)

(Submitter supplied) E protein transcription factors specify major immune cell lineages including lymphocytes and interferon-producing plasmacytoid dendritic cells (pDCs). Corepressors of the ETO family can bind to and block transactivation by E proteins, but the physiological role of these interactions remained unclear. We report that ETO protein Mtg16 binds chromatin primarily through the pDC-specific E protein E2-2 in human pDCs. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
3 Samples

Download data: BED

Series

Accession:: GSE43876

ID:: 200043876

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20004387411.

Mtg16 regulates E protein activity and lineage specification in dendritic cell development (gene expression)

(Submitter supplied) E protein transcription factors specify major immune cell lineages including lymphocytes and interferon-producing plasmacytoid dendritic cells (pDCs). Corepressors of the ETO family can bind to and block transactivation by E proteins, but the physiological role of these interactions remained unclear. We report that ETO protein Mtg16 binds chromatin primarily through the pDC-specific E protein E2-2 in human pDCs. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
2 Samples

Download data: CEL

Series

Accession:: GSE43874

ID:: 200043874

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014442112.

Tissue-specific factors differentially regulate the expression of antigen-processing enzymes during dendritic cell ontogeny

(Submitter supplied) Dendritic cells (DC) form a collection of antigen-presenting cells that are distributed throughout the body. Conventional DC (cDC) which include the cDC1 and cDC2 subsets, and plasmacytoid DC (pDC) constitute the two major ontogenically distinct DC populations. The pDC complete their differentiation in bone-marrow (BM) while the cDC subsets derive from pre-committed bone-marrow (BM) precursors, the pre-cDC, that seed lymphoid and non-lymphoid tissues where they further differentiate into mature cDC1 and cDC2. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
21 Samples

Download data: TXT

Series

Accession:: GSE144421

ID:: 200144421

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20002243213.

TGF-β1 Accelerates Dendritic Cell Differentiation from Common Dendritic Cell Progenitors (CDPs) and Directs Subset Specification Towards Conventional Dendritic Cells

(Submitter supplied) Dendritic cells (DCs) in lymphoid tissue comprise conventional DCs (cDCs) and plasmacytoid DCs (pDCs) that develop from common DC progenitors (CDPs). CDPs are Flt3+c-kitintM-CSFR+ and reside in bone marrow. Here we describe a two-step culture system that recapitulates DC development from c-kithiFlt3-/lo multipotent progenitors (MPPs) into CDPs and further into cDC and pDC subsets. MPPs and CDPs are amplified in vitro with Flt3 ligand, stem cell factor, hyper-IL-6 and insulin- like growth factor-1. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
20 Samples

Download data: CEL

Series

Accession:: GSE22432

ID:: 200022432

Select item 20013096614.

Plasmacytoid dendritic cells develop from Ly6D+ lymphoid progenitors distinct from the myeloid lineage

(Submitter supplied) We provide a comprehensive single cell mRNA-seq analyses of mouse bone marrow progenitors revealing early lineage commitment in the bone marrow.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
614 Samples

Download data: TXT

Series

Accession:: GSE130966

ID:: 200130966

PubMed Similar studies SRA Run Selector

Select item 20006078315.

Identification of subset-specific dendritic cell progenitors reveals early commitment in the bone marrow

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL13112 GPL6887
275 Samples

Download data: TXT

Series

Accession:: GSE60783

ID:: 200060783

Select item 20006078216.

Identification of subset-specific dendritic cell progenitors reveals early commitment in the bone marrow [Microarray Expression]

(Submitter supplied) Dendritic cells (DCs) are antigen sensing and presenting cells that are essential for effective immunity. Existing as a multi-subset population, divided by distinct developmental and functional characteristics1,2, DC subsets play important and unique roles in responses to pathogens, vaccines and cancer therapies, as well as during immune-pathologies. Therefore therapeutic manipulation of the DC compartment is an attractive strategy. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
24 Samples

Download data: TXT

Series

Accession:: GSE60782

ID:: 200060782

Select item 20006078117.

Identification of subset-specific dendritic cell progenitors reveals early commitment in the bone marrow [RNA-Seq]

(Submitter supplied) Dendritic cells (DCs) are antigen sensing and presenting cells that are essential for effective immunity. Existing as a multi-subset population, divided by distinct developmental and functional characteristics1,2, DC subsets play important and unique roles in responses to pathogens, vaccines and cancer therapies, as well as during immune-pathologies. Therefore therapeutic manipulation of the DC compartment is an attractive strategy. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
251 Samples

Download data: TXT

Series

Accession:: GSE60781

ID:: 200060781

PubMed Similar studies SRA Run Selector

Select item 20003799618.

Tissue-specific differentiation of a circulating CCR9- pDC-like common dendritic cell precursor

(Submitter supplied) Committed precursors of conventional dendritic cells (pre-cDCs) derived from the common DC progenitor which differentiate into cDC subpopulations in peripheral tissues have been identified, but committed precursors for plasmacytoid DCs (pDCs) have not been found. Here we show that CDP-derived ‘CCR9- MHCIIlow BST2+ Siglec-H+ pDCs from murine bone marrow which enter the circulation and peripheral tissues have a common DC precursor function in vivo in the steady state. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
6 Samples

Download data: TXT

Series

Accession:: GSE37996

ID:: 200037996

Select item 20006689919.

Batf3 maintains Irf8 autoactivation for commitment of a novel clonogenic progenitor of CD8+DCs

(Submitter supplied) The transcription factors Batf3 and IRF8 are required for development of CD8α+ conventional dendritic cells (cDCs), but the basis for their actions was unclear. Here, we identify two novel Zbtb46+ progenitors that separately generate CD8α+ and CD4+ cDCs and arise directly from the common DC progenitor (CDP). Irf8 expression in the CDP depends on prior PU.1-dependent autoactivation, and specification of pre-CD8 DC progenitors requires IRF8 but not Batf3. more...