GEO DataSets

(Submitter supplied) This two-color miRNA chip was perfored to identify the downstream miRNAs regulated by Notch signaling in macrophage polarization.

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL13493

6 Samples

Download data: TXT

(Submitter supplied) To further analyze the change of microRNA(miRNA) between normal peritoneal macrophage(PEC) and TAM from early tumor(12 days after 4T1 cell injection) or TAM from late tumor(21 days after 4T1 cell injection) , we employed Agilent mouse microRNA microarray Rel 12.0 as a discovery platform to identify miRNAs

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL9756

9 Samples

Download data: TXT

(Submitter supplied) By employing miRCURY LNA™ microRNA Array, we have identified a subset of 21 top miRNAs that are differentially expressed between GM-BMM and M-BMM cells

Organism:

Mus musculus; Human gammaherpesvirus 8; Rattus norvegicus; Human alphaherpesvirus 2; JC polyomavirus; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Human alphaherpesvirus 1; human gammaherpesvirus 4; Mus musculus cytomegalovirus 2; Betapolyomavirus macacae; Homo sapiens; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Merkel cell polyomavirus

Type:

Non-coding RNA profiling by array

Platform:

GPL11434

4 Samples

Download data: TXT

(Submitter supplied) In an attempt to identify miRNAs regulated by oncogenic Notch signaling, we performed miRNA profiling of human T-cell acute lymphoblastic leukemia (T-ALL) cells with or without the treatment of γ-secretase inhibitor (GSI) to block Notch signaling. We found miR-223 levels to increase after GSI treatment suggesting that active Notch signaling represses miR-223 expression. We confirmed insulin-like growth factor-1 receptor (IGF1R) to be regulated by miR-223, but were unable to demonstrate functional effects on T-ALL cell growth by overexpression or knock-down of miR-223 alone.

Organism:

Murid gammaherpesvirus 4; Betapolyomavirus hominis; human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae; Rattus norvegicus; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1

Type:

Non-coding RNA profiling by array

Platform:

GPL7723

4 Samples

Download data: TXT

(Submitter supplied) Tumor-associated macrophages (TAMs) represent alternatively activated (M2) macrophages that support tumor growth. Previously, we have described a special LYVE-1(+) M2 TAM subset in vitro and in vivo; gene profiling of this TAM subset identified MS4A8A as a novel TAM molecule expressed in vivo by TAM in mammary carcinoma and malignant melanoma. In vitro, Ms4a8a mRNA and MS4A8A protein expression was strongly induced in bone marrow-derived macrophages (BMDMs) by combining M2 mediators (IL-4, glucocorticoids) and tumor-conditioned media (TCM). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL15041

6 Samples

Download data: CEL

(Submitter supplied) Analysis of bone marrow derived macrophages (BMDM) incubated with dexamethasone&IL4 (Dexa+IL4), B16F1 tumor conditioned medium (cmB16), and B16F1 tumor conditioned medium supplemented with dexamethasone&IL4 (cmB16+dexa+IL4). Results allow detection of genes that require synergistic stimulation of tumor factors and Th2 cytokines.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6526

9 Samples

Download data: CEL

(Submitter supplied) we demonstrate Notch1 pathway dictates M1 activation in mouse hepatic macrophages (HMacs) and Raw 264.7 cells by coupling its transcriptional upregulation of M1 genes with its metabolic upregulation of mitochondrial oxidative phosphorylation and ROS (mtROS) to augment the M1 gene induction. We used a genome wide Chip-seq approach to study in detail the transcriptional mechanism associated with Notch1

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL13112

4 Samples

Download data: BEDGRAPH, BW

(Submitter supplied) miR-125a knockout mice develop myeloproliferave disorder (MPD). To investigate the molecular mechanisms of MPD induced by the loss of miR-125a, gene expression profiling on hematopoietic stem cells of miR-125a (+/+) and (+/-) MPD mice was performed using CodeLink Whole Genome DNA array analysis.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL5973

2 Samples

Download data: XLS

(Submitter supplied) The goal of this study is to compare transcriptome profiling of different populations of CD45 immune cells of isolated from LLC tumors from miR-21 conditionally deleted on LysM expressing cells (mir-21 flox/flox; lysmCre) mice vs. control (mir-21flox/flox) mice.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

2 Samples

Download data: MTX, TSV

(Submitter supplied) The goal of this study is to compare transcriptome profiling of miR-21 null TAMs vs. WT macrophages isolated from LLC tumors

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

8 Samples

Download data: TXT