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MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.
PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector
Epigenetic profiling of hematopoietic stem cells and leukemia stem cells
PubMed Full text in PMC Similar studies SRA Run Selector
Expression changes after loss of Dot1l in murine MLL-AF9 leukemia cells
PubMed Full text in PMC Similar studies Analyze with GEO2R
Histone methyltransferase H3K79 Dot1l deletion effect on MLL-AF9 leukemia cells: time course
PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet
H3K79 methylation profiles define murine and human MLL-AF4 leukemias
Genome-wide analysis of H3K79 dimethylation in MLL-AF4 leukemic bone marrow
PubMed Full text in PMC Similar studies
Genome-wide analysis of H3K79 dimethylation in normal and MLL-AF4 leukemic pre-B cells
Genome-wide analysis of H3K79 methylation in CD34+ CD19+ cells from normal marrow, MLL-rearranged or MLL-germline ALL
Expression profiling of activated or control 5-FU bone marrow from MLL-AF4stop knockin mice
Expression profiling of normal murine lymphoid progenitors and MLL-AF4 leukemic lymphoblasts
DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation (RNA-seq)
DOT1L inhibition reveals a distinct class of enhancers dependent upon H3K79 methylation
DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation (ChIP-seq)
DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation (Capture-C)
DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation (ATAC-seq)
MLL-AF4 binds directly to a BCL-2 specific enhancer and impacts H3K27 acetylation
Gene expression induced by DOT1L and Menin inhibition in cell line models of leukemia
PubMed Similar studies Analyze with GEO2R
DOT1L Inhibits SIRT1 and SUV39H1-Mediated H3K9 Modification to Maintain Gene Expression
Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential
H3K79me2/3 controls enhancer promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells
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