GEO DataSets

(Submitter supplied) Genome wide DNA methylation profiling of 89 primary invasive FFPE melanomas and 73 nevi were evaluated using the Illumina Infinium HumanMethylation450 BeadChip array

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL13534

162 Samples

Download data: IDAT, TXT

(Submitter supplied) Genome wide genomic DNA profiling with the HumanMethylation450 BeadChip (450k) of skin samples. The skin tissue DNA was derived from a peri-umbilical punch biopsy (adipose tissue was removed from the biopsy before freezing) from 322 healthy female twins of the TwinsUK cohort. Family structure is present in this data. If the samples are related they will share a similar Relatedness identification ID either monozygotic_twinpair_* or dizygotic_twinpair_*

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL13534

322 Samples

Download data: TXT

(Submitter supplied) Using 1 melanocyte and 6 melanoma cell line (3 pair of primary and metastatic), we generated base-resolution DNA methylation maps to document DNA methylation drivers of melanoma metastasis.

Organism:

Homo sapiens

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL16791

7 Samples

Download data: TXT

(Submitter supplied) Cutaneous, ocular and mucosal melanomas are histologically indistinguishable tumors that are driven by different spectrum of genetic alterations. With current methods, identification of the site of origin of a melanoma metastasis is challenging, in particular when the metastasis is the first tumor manifestation. Genome wide DNA methylation profiling has shown promise for the identification of the site of tumor origin in various settings. more...

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL21145

115 Samples

Download data: IDAT

(Submitter supplied) We subjected 196 melanoma tumors to genome-wide methylation analysis using the Illumina Infinium MethylationEPIC BeadChip array.

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL21145

196 Samples

Download data: TXT, XLSX

(Submitter supplied) Genome wide methylation of superficial malignant peripheral nerve sheath tumors and spindle cell melanomas. EPIC HD 850K array is used to identifiy differentally methylated promoter region probes and unique methyome signatures. Superficial/cutaneous malignant peripheral nerve sheath tumor (c-MPNST) is a rare, soft tissue neoplasm that shares morphological, immunohistochemical and molecular with spindle and desmoplastic melanoma (SDM). more...

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL23976

30 Samples

Download data: IDAT, TXT

(Submitter supplied) Epigenetic regulation of tumor suppressor genes (TSGs) has been shown to play a central role in melanomagenesis. Integrating gene expression and methylation array analysis we identified novel candidate TSGs frequently methylated in melanoma. We validated the methylation status of the most promising TSGs using the highly sensitive, specific and comprehensive Sequenom Epityper assay in a large panel of melanoma cell lines and resected melanomas, and compared the findings with that from cultured melanocytes. more...

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL8490

12 Samples

Download data: TXT

(Submitter supplied) DNA methylation profile from three pairs of cell lines (WM115/W226-4 ; M4Be/M4BeS2 ; M4Be/TW12) with common genetic background (human) and derived in tree different organisms (human-rat-mouse) were analysed by Infinium Human Methylation 450 K bead arrays (Illumina Inc., San Diego, CA). The WM-115 cell line was derived from a human primary melanoma in early stage of vertical growth phase (VGP). The WM-266-4 cell line was derived from a cutaneous metastatic site of a malignant melanoma. more...

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL13534

15 Samples

Download data: CSV, IDAT

(Submitter supplied) Genome-wide DNA methylation profiling of melanoma samples. The Illumina Infinium Human DNA methylation EPIC Beadchip Kit was used to obtain DNA methylation profiles across approximately 850,000 CpGs.

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL21145

30 Samples

Download data: IDAT

(Submitter supplied) Genome-wide DNA methylation profiling of brain metastases from lung cancer, breast cancer, and melanoma samples. The Illumina Infinium 450K Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 450,000 methylation sites in formalin-fixed paraffin-embedded (FFPE) samples from brain metastases. Samples included 30 breast cancer brain metastases, 18 lung cancer brain metastases, 37 melanoma brain metastases, and 4 samples with brain metastases from patients with uncertain primary.

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL13534

89 Samples

Download data: IDAT, TXT

(Submitter supplied) Novel screening techniques are allowing the depiction of the portraits of molecular alterations across cancer types, enabling a better understanding of the progression mechanisms and providing new therapeutic targets. Here, we performed an unbiased genome-wide DNA methylation analysis to interrogate the epigenetic events characterizing melanoma progression and prognosis, on a discovery cohort of clinical specimens. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL13534

75 Samples

Download data: TXT

(Submitter supplied) Despite the advantages of neoadjuvant chemotherapy (NACT), associated toxicity is a serious complication that renders monitoring of the patients response to NACT highly important. Thus, prediction of tumor response to treatment is imperative to avoid exposure of potential non-responders to deleterious complications. We have performed genome-wide analysis of DNA methylation by XmaI-RRBS and selected CpG dinucleotides differential methylation of which discriminates luminal B breast cancer samples with different sensitivity to NACT. more...

Organism:

Homo sapiens

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL17301

25 Samples

Download data: COV

(Submitter supplied) The 2021 WHO Classification of Tumors of the Central Nervous System includes several tumor types and subtypes for which the diagnosis is at least partially reliant on utilization of whole genome methylation profiling. The current approach to array DNA methylation profiling utilizes a reference library of tumor DNA methylation data, and a machine learning-based tumor classifier. This approach was pioneered and popularized by the German Cancer Research Network (DKFZ) and University Hospital Heidelberg. more...

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL23976

84 Samples

Download data: IDAT, TSV