Similar studies for GEO DataSets (Select 2601) - GEO DataSets

Select item 26011.

Analysis of blood mononuclear cells of sporadic Alzheimer disease (AD) and age- gender-matched normal controls. Results reveal insights into systemic nature of gene dys-regulation in sporadic AD and suggest novel pathways of beta-amyloid deposition.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 disease state, 2 gender sets

Platform:: GPL1211
Series:: GSE4226
28 Samples

Download data

DataSet

Accession:: GDS2601

ID:: 2601

Select item 2000042292.

Alzheimer disease diagnostic prediction using peripheral BMC gene expression

(Submitter supplied) Using prediction analysis for microarrays (PAM), peripheral blood mononuclear cells (BMC) gene expression proves useful as predictive markers of sporadic AD. We obtained 90% accuracy for correct AD classification by PAM (36 of 40; four NEC classified as AD) using BMC gene expression. Investigating the contribution of these genes to the pathology of AD and their usefulness as prognostic biomarkers holds promise in the prevention of this devastating disease.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL1211
40 Samples

Download data

Series

Accession:: GSE4229

ID:: 200004229

Select item 2000042273.

GSTM3 single nucleotide polymorphism (rs7483) associated with peripheral BMC expression in Alzheimer disease

(Submitter supplied) Comparisons between the sample groups (normal elderly control (NEC) and Alzheimer disease (AD)) allowed the identification of genes with disease expression patterns associated with the glutathione S-transferase M3 single nucleotide polymorphism rs7483. Keywords: biological repeat

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL1211
34 Samples

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Series

Accession:: GSE4227

ID:: 200004227

Select item 2000042264.

Alzheimer Disease peripheral blood mononuclear cell expression

(Submitter supplied) Comparisons between the sample groups (normal elderly control (NEC) and Alzheimer disease (AD)) allow the identification of genes with disease and gender expression patterns. Keywords: biological repeat

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2601
Platform:: GPL1211
28 Samples

Download data

Series

Accession:: GSE4226

ID:: 200004226

Select item 2000053905.

Expression profiling of human adult postmortem brain tissue from Down syndrome and healthy control subjects

(Submitter supplied) Down syndrome (DS) is the result of trisomy chromosome 21 but the mechanisms by which the genotype leads to the characteristic disease phenotype are unclear. We performed a microarray study using human adult brain tissue (dorsolateral prefrontal cortex) from DS subjects and healthy controls to characterise for the first time the human adult Down syndrome brain Keywords: disease state analysis

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2941
Platform:: GPL96
15 Samples

Download data: CEL

Series

Accession:: GSE5390

ID:: 200005390

Select item 29416.

Down syndrome: brain

Analysis of postmortem brains of individuals with Down syndrome. Results provide insight into the pathogenesis of Down syndrome.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 disease state sets

Platform:: GPL96
Series:: GSE5390
15 Samples

Download data: CEL

DataSet

Accession:: GDS2941

ID:: 2941

Select item 2000061297.

Arsenate stress response: Saccharomyces cerevisiae

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Platform:: GPL4462
30 Samples

Download data: GPR, IMAGENE

Series

Accession:: GSE6129

ID:: 200006129

Select item 2000060728.

0.2 mM As(III) stressed met4 deletion mutant vs 0.2 mM As(III) stressed wild-type after 1 hour

(Submitter supplied) Arsenic is ubiquitously present in nature and various mechanisms have evolved enabling cells to evade toxicity and acquire tolerance. Herein, we explored how Saccharomyces cerevisiae (budding yeast) respond to trivalent arsenic (arsenite) by quantitative and kinetic transcriptome, proteome and sulfur metabolite profiling. Arsenite exposure affected transcription of genes encoding functions related to protein biosynthesis, arsenic detoxification, oxidative stress defense, redox maintenance and proteolytic activity. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Platform:: GPL4462
6 Samples

Download data: IMAGENE

Series

Accession:: GSE6072

ID:: 200006072

Select item 2000060719.

1.0 mM As(III) stressed yap1 deletion mutant vs 1.0 mM As(III) stressed wild-type after 1 hour

(Submitter supplied) volved enabling cells to evade toxicity and acquire tolerance. Herein, we explored how Saccharomyces cerevisiae (budding yeast) respond to trivalent arsenic (arsenite) by quantitative and kinetic transcriptome, proteome and sulfur metabolite profiling. Arsenite exposure affected transcription of genes encoding functions related to protein biosynthesis, arsenic detoxification, oxidative stress defense, redox maintenance and proteolytic activity. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Platform:: GPL4462
3 Samples

Download data: GPR

Series

Accession:: GSE6071

ID:: 200006071

Select item 20000607010.

0.2 mM As(III) stressed yap1 deletion mutant vs 0.2 mM As(III) stressed wild-type after 1 hour

(Submitter supplied) Arsenic is ubiquitously present in nature and various mechanisms have evolved enabling cells to evade toxicity and acquire tolerance. Herein, we explored how Saccharomyces cerevisiae (budding yeast) respond to trivalent arsenic (arsenite) by quantitative and kinetic transcriptome, proteome and sulfur metabolite profiling. Arsenite exposure affected transcription of genes encoding functions related to protein biosynthesis, arsenic detoxification, oxidative stress defense, redox maintenance and proteolytic activity. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Platform:: GPL4462
3 Samples

Download data: IMAGENE

Series

Accession:: GSE6070

ID:: 200006070

Select item 20000606811.

Time Course 1.0 mM As(III)

(Submitter supplied) Arsenic is ubiquitously present in nature and various mechanisms have evolved enabling cells to evade toxicity and acquire tolerance. Herein, we explored how Saccharomyces cerevisiae (budding yeast) respond to trivalent arsenic (arsenite) by quantitative and kinetic transcriptome, proteome and sulfur metabolite profiling. Arsenite exposure affected transcription of genes encoding functions related to protein biosynthesis, arsenic detoxification, oxidative stress defense, redox maintenance and proteolytic activity. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Platform:: GPL4462
15 Samples

Download data: GPR, IMAGENE

Series

Accession:: GSE6068

ID:: 200006068

Select item 20000606712.

0.2 mM As(III) stressed wild-type vs (non-stressed) wild-type after 1 hour

(Submitter supplied) Arsenic is ubiquitously present in nature and various mechanisms have evolved enabling cells to evade toxicity and acquire tolerance. Herein, we explored how Saccharomyces cerevisiae (budding yeast) respond to trivalent arsenic (arsenite) by quantitative and kinetic transcriptome, proteome and sulfur metabolite profiling. Arsenite exposure affected transcription of genes encoding functions related to protein biosynthesis, arsenic detoxification, oxidative stress defense, redox maintenance and proteolytic activity. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Platform:: GPL4462
3 Samples

Download data: IMAGENE

Series

Accession:: GSE6067

ID:: 200006067

Select item 20000606613.

1.0 mM As(III) stressed wild-type vs (non-stressed) wild-type after 1 hour

(Submitter supplied) Arsenic is ubiquitously present in nature and various mechanisms have evolved enabling cells to evade toxicity and acquire tolerance. Herein, we explored how Saccharomyces cerevisiae (budding yeast) respond to trivalent arsenic (arsenite) by quantitative and kinetic transcriptome, proteome and sulfur metabolite profiling. Arsenite exposure affected transcription of genes encoding functions related to protein biosynthesis, arsenic detoxification, oxidative stress defense, redox maintenance and proteolytic activity. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Platform:: GPL4462
6 Samples

Download data: GPR

Series

Accession:: GSE6066

ID:: 200006066

Select item 20000842514.

Laser microdissection and microarray analysis of the hippocampus of Rasgrf1 knockout mice

(Submitter supplied) We used manual macrodissection or laser capture microdissection (LCM) to isolate tissue sections of the hippocampus area of Ras-GRF1 wild type and knockout mice brains, and analyzed their transcriptional patterns using commercial oligonucleotide microarrays. Comparison between the transcriptomes of macrodissected and microdissected samples showed that the LCM samples allowed detection of significantly higher numbers of differentially expressed genes, with higher statistical rates of significance. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2816
Platform:: GPL339
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE8425

ID:: 200008425

Select item 281615.

Ras-GRF1 deficiency effect on the hippocampus

Analysis of laser capture microdissected hippocampi of mutants lacking Ras-GRF1. Ras-GRF-1 is a guanine nucleotide exchange factor predominantly expressed in the central nervous system of mammals. Results provide insight into role of Ras-GRF1 in neural processes.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL339
Series:: GSE8425
6 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS2816

ID:: 2816

Select item 20000860216.

Early responsive genes in human amnion epithelial FL cells induced by N-methyl-N’-nitro-N-nitrosoguanidine

(Submitter supplied) The alkylating agent N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) induces cellular DNA damages and other comprehensive alterations that lead to chromosomal aberrations, mutations, tumor initiations, and cell death. However, the molecular mechanism of MNNG-induced cellular stress remains unclear.We have genome-wide analyzed early transcriptional responses of human FL amnion epithelial cells after exposure to three relatively low doses of MNNG (0.2, 1.0, and 10.0µM),and differential gene expression profiles were obtained 4 h after exposure using oligonucleotide microarrays followed by validation with quantitative real-time RT-PCR. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL96 GPL97
16 Samples

Download data: CEL, EXP

Series

Accession:: GSE8602

ID:: 200008602

Select item 20001074817.

Expression data from brain tissue of Rattus norvegicus treated with D-Serine

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS3643
Platform:: GPL1355
24 Samples

Download data: CEL

Series

Accession:: GSE10748

ID:: 200010748

Select item 364318.

D-serine effect on the brain: dose response

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 agent, 6 dose sets

Platform:: GPL1355
Series:: GSE10748
24 Samples

Download data: CEL

DataSet

Accession:: GDS3643

ID:: 3643

Select item 20000835019.

mRNA expression profile in peripheral blood cells of RA patients following treatment with an anti-TNFa mAb, infliximab

(Submitter supplied) Objectives: We monitored the mRNA expression profiles of peripheral blood cells during treatment with a tumor necrosis factor-a inhibitor, infliximab, in patients with rheumatoid arthritis (RA). Using a DNA microarray analysis, we demonstrated a unique set of genes, with distinct baseline and post-treatment changes in expression between responders and non-responders to infliximab treatment.Methods: Using a customized low-density cDNA microarray and a reliable data collection system, we monitored the mRNA expression profiles of whole blood cells from 18 RA patients before and after the infusion of infliximab for up to 22 weeks. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5460
72 Samples

Download data: TXT

Series

Accession:: GSE8350

ID:: 200008350

Select item 20000681920.

Identification of genes that are linked with optineurin expression

(Submitter supplied) This study aimed to identify genes that are linked with optineurin expression using a combined siRNA-microarray approach Keywords: siRNA treatment study

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2892
Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE6819

ID:: 200006819

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