GEO DataSets

Analysis of anterior and posterior stomach regions following vagotomy of anterior stomach of 6 month old INS-GAS animals at 2, 4, and 6 months post-surgery. Results provide insight into molecular mechanisms underlying denervation-mediated suppression of gastric tumorigenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 time, 2 tissue sets

Platform:

GPL6887

Series:

GSE30295

32 Samples

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(Submitter supplied) A vagotomy of the anterior region of the stomach of INS-GAS mice was performed at 6 month of age. The mice were sacrificed at 8, 10 and 12 months of age, The gene expression of the anterior and posterior regions of the stomach was compared at each time point.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5336

Platform:

GPL6887

32 Samples

Download data: TXT

(Submitter supplied) Noxo1, a component of NADPH oxidase 1 (NOX1) complex, is upregulated in gastric cancer cells in a inflammation-dependent manner, and plays an important role in tumorigenesis (Oncogene, 33: 3820, 2014). To examine the mechanism of NOX1/ROS signaling in tumorigenesis, MKN45 gastric cancer cells were treated with apocynin, an inhibitor for NOX, and their gene expression was examined by RNA sequencing. Based on expression data, Sox2 was shown to be suppressed by apocynin, suggesting a role of Sox2 in a inflammation-associated gastric tumorigenesis.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

4 Samples

Download data: XLSX

(Submitter supplied) Gan mice express Wnt1, Ptgs2, and Ptges, which develop inflammation-associated gastric tumors (Oshima et al, Gastroenterology 131: 1086, 2006). We examined the role of MyD88 in tumorigenesis by construction of Myd88-/- Gan mice and bone marrow transplantation into Gan mice from Myd88-/- mice.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

15 Samples

Download data: TXT

(Submitter supplied) Carcinogenic bacteria, Helicobacter pylori, induce DNA double-strand breaks in infected host cells, while ATM-dependent DNA damage responses in host cells suppress genome instabilities caused by DNA breakages, which resulting in the suppression of H. pylori-induced gastric cancers. Although Helicobacter pylori infection is etiologically related to the inflammation-related malignancy, gastric cancers, it role in the molecular pathogenesis of disease remains unclear. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13497

16 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL17077 GPL13497

24 Samples

Download data: TXT

(Submitter supplied) We have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish between the gastric cancer and adjacent nontumor tissue. The human gastric cancer tissue belonging to low-differentiated adenocarcinoma and adjacent nontumor tissue were analysed. Expression of TIPE1 and Wnt family from this signature was quantified in the same kind of samples by real-time PCR, confirming the change pattern.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

2 Samples

Download data: TXT

(Submitter supplied) Isolating adult stem cells from human stomach epithelia has proven challenging due to a lack of surface markers that are amenable to antibody-based sorting approaches. Here, through comparative expression profiling of mouse Lgr5+ adult stem cells along the gastrointestinal tract, we identify novel pylorus-specific stem cell markers, including the membrane protein Aqp5. FACS-based isolation of endogenous AQP5+ cells from healthy human pyloric stomach revealed their stem cell identity in organoid assays. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

16 Samples

Download data: TXT

(Submitter supplied) Isolating adult stem cells from human stomach epithelia has proven challenging due to a lack of surface markers that are amenable to antibody-based sorting approaches. Here, through comparative expression profiling of mouse Lgr5+ adult stem cells along the GI tract, we identify novel pylorus-specific stem cell markers, including the membrane protein Aqp5. FACS-based isolation of endogenous AQP5+ cells from healthy human pyloric stomach revealed their stem cell identity in organoid assays. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

42 Samples

Download data: CEL

(Submitter supplied) mRNA profiles in PAF KO intestinal adenoma

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL23479 GPL21103

4 Samples

Download data: TXT

(Submitter supplied) Cyclooxygenase-2 (COX-2), the rate-limiting enzyme for prostanoid biosynthesis, plays a key role in gastrointestinal carcinogenesis. Among various prostanoids, prostaglandin E2 (PGE2) appears to be most responsible for cancer development. To investigate the role of PGE2 in gastric tumorigenesis, we constructed transgenic mice simultaneously expressing COX-2 and microsomal prostaglandin E synthase (mPGES)-1 in the gastric epithelial cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL3264

3 Samples

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