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Links from GEO DataSets

Items: 9

1.
Full record GDS5608

NF-κB subunit p65 depletion effect on Ras-induced transformation model: cultured embryonic fibroblasts

Analysis of p65+/+Ras and p65-/-Ras cells generated by infecting NF-κB subunit p65+/+ and p65-/- MEFs with pBabe-HRASG12V. Post-injection of the Ras cells into SCID mice, RasT tumors were removed, reconstituted in culture and examined. Results provide insight into role of NF-κB in tumorigenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 cell line, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE59545
4 Samples
Download data: CEL, DCP, TXT
2.

NF-kB in Tumor Initiation

(Submitter supplied) p65-/-Ras cells show delayed tumor formation in SCID mice. However, after prolonged latency, tumor formation was observed from these mice. To understand the changes of NF-kB regulated genes before and after tumor formation, RNA from p65+/+Ras, p65+/+RasTumor, p65-/-Ras, p65-/-RasTumor cells were isolated and microarray were performed.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5608
Platform:
GPL1261
4 Samples
Download data: CEL, DCP, TXT
Series
Accession:
GSE59545
ID:
200059545
3.

RNA Sequencing looking at differential gene expression between p65+/+ and p65-/- mouse embryonic fibroblasts (MEFs)

(Submitter supplied) We look at differential gene expression between immortalized p65+/+ and p65-/- MEFs to identify potential NF-kB regulated genes which when grouped based on biological function indicates candidates involved in protecting p65+/+ cells from macrophage-mediated killing
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
2 Samples
Download data: TXT
Series
Accession:
GSE101092
ID:
200101092
4.

Developmental LTbR synergistically activates TLR4 mediated inflammatory RelA/NF-kB response

(Submitter supplied) Developmental signals are known to modulate inflammation. How ever, the mechanistic insight that links developmental and inflammatory signaling remains elusive. In the current study, we identifya critical role of NF-kB system in mediating stimulus specific crosstalk that allows developmental LTbR signals to sustain inflammatory TLR4 induced RelA/NF-kB response and gene expression. LTbR activated non-canonical signaling targets canonical TLR4 induced, nfkb2 encoded p100 not only to deplete inhibitory IkBd/(p100)2, but also to supplement RelA:p52/NF-kB dimers. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5655
Platform:
GPL6885
4 Samples
Download data: TXT
Series
Accession:
GSE62301
ID:
200062301
5.
Full record GDS5655

Lymphotoxin-β receptor agonist antibody effect on lipopolysaccharide-stimulated embryonic fibroblasts

Analysis of MEFs treated for 24hrs with ligands lipopolysaccharide (LPS), lymphotoxin-β receptor agonist antibody (LTβR), and LPS+ LTβR. Results provide insight into molecular mechanisms underlying a potentially synergistic effect of LTβR signaling on LPS-TLR4 signaling.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 protocol sets
Platform:
GPL6885
Series:
GSE62301
4 Samples
Download data
6.

DNA copy number and gene expression profiles of resected non-small cell lung cancer tumors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array; Expression profiling by array
Platforms:
GPL14189 GPL14360
320 Samples
Download data: CEL, TXT
Series
Accession:
GSE31800
ID:
200031800
7.

Gene expression profiles of NSCLC tumors

(Submitter supplied) A custom microarray was used to measure the gene expression of NSCLC tumors. This represents a subset of samples which also have matched DNA copy number profiles from array CGH experiments
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL14189
49 Samples
Download data: CEL
Series
Accession:
GSE31799
ID:
200031799
8.

DNA copy number profiles of NSCLC tumors

(Submitter supplied) Whole genome tiling path array CGH was used to measure the copy number profiles of 271 NSCLC tumors
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL14360
271 Samples
Download data: TXT
Series
Accession:
GSE31798
ID:
200031798
9.

Chromosomal aberrations in Tak1-/- mice

(Submitter supplied) Characterization of chromosomal aberrations in liver tumors of Tak1-/- mice of different ages The aim of the project is to dissect signaling mechanisms which could be of importance during the process of liver carcinogenesis. Keywords: Array comparative genomic hybridization analysis (aCGH).
Organism:
Mus musculus
Type:
Genome variation profiling by array
Platform:
GPL8086
20 Samples
Download data: TXT
Series
Accession:
GSE19105
ID:
200019105
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