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rgl3a ral guanine nucleotide dissociation stimulator-like 3a [ Danio rerio (zebrafish) ]

Gene ID: 100149956, updated on 11-Apr-2024

Summary

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Official Symbol
rgl3aprovided by ZNC
Official Full Name
ral guanine nucleotide dissociation stimulator-like 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-101130-1
See related
Ensembl:ENSDARG00000071213 AllianceGenome:ZFIN:ZDB-GENE-101130-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within positive regulation of GTPase activity and small GTPase mediated signal transduction. Orthologous to human RGL3 (ral guanine nucleotide dissociation stimulator like 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See rgl3a in Genome Data Viewer
Location:
chromosome: 6
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (8210115..8244789, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (7974580..8009834, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene nuclear factor, interleukin 3 regulated, member 3 Neighboring gene nuclear factor, interleukin 3 regulated, member 5 Neighboring gene outer dynein arm docking complex subunit 3 Neighboring gene solute carrier family 44 member 2 (CTL2 blood group)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ral guanine nucleotide dissociation stimulator-like 3; ral guanine nucleotide dissociation stimulator-like 1
Names
rgl3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    8210115..8244789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165751.4 → XP_005165808.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X1

    See identical proteins and their annotated locations for XP_005165808.1

    UniProtKB/TrEMBL
    A0A8M2BD17
    Conserved Domains (3) summary
    cd00153
    Location:677 → 763
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:259 → 541
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00618
    Location:106 → 189
    RasGEF_N; RasGEF N-terminal motif

  2. XM_009302164.3 → XP_009300439.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M3BA68
    Conserved Domains (3) summary
    cd00153
    Location:676 → 762
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:259 → 540
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00618
    Location:106 → 189
    RasGEF_N; RasGEF N-terminal motif

  3. XM_009302163.3 → XP_009300438.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X1

    See identical proteins and their annotated locations for XP_009300438.1

    UniProtKB/TrEMBL
    A0A8M2BD17
    Conserved Domains (3) summary
    cd00153
    Location:677 → 763
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:259 → 541
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00618
    Location:106 → 189
    RasGEF_N; RasGEF N-terminal motif

  4. XM_009302166.3 → XP_009300441.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M3B368, I3IT01
    Related
    ENSDARP00000126052.1, ENSDART00000151358.3
    Conserved Domains (3) summary
    cd00153
    Location:674 → 760
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:259 → 540
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00618
    Location:106 → 189
    RasGEF_N; RasGEF N-terminal motif

  5. XM_009302165.3 → XP_009300440.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AT51
    Conserved Domains (3) summary
    cd00153
    Location:675 → 761
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:259 → 541
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00618
    Location:106 → 189
    RasGEF_N; RasGEF N-terminal motif

  6. XM_001921184.6 → XP_001921219.3  ral guanine nucleotide dissociation stimulator-like 1 isoform X5

    UniProtKB/TrEMBL
    A0A8M1QUZ8
    Conserved Domains (3) summary
    cd00153
    Location:629 → 715
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:211 → 493
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00618
    Location:58 → 141
    RasGEF_N; RasGEF N-terminal motif

  7. XM_021476991.1 → XP_021332666.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X6

    UniProtKB/TrEMBL
    A0A8M9QAN2
    Conserved Domains (2) summary
    cd00153
    Location:268 → 354
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    cl02485
    Location:47 → 132
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394626.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    34554..84418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021471711.1 → XP_021327386.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q1W3
    Conserved Domains (3) summary
    cd00153
    Location:677 → 763
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:259 → 541
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00618
    Location:106 → 189
    RasGEF_N; RasGEF N-terminal motif

  2. XM_021471712.1 → XP_021327387.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9P937
    Conserved Domains (3) summary
    cd00153
    Location:676 → 762
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:259 → 540
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00618
    Location:106 → 189
    RasGEF_N; RasGEF N-terminal motif

  3. XM_021471710.1 → XP_021327385.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q1W3
    Conserved Domains (3) summary
    cd00153
    Location:677 → 763
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:259 → 541
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00618
    Location:106 → 189
    RasGEF_N; RasGEF N-terminal motif

  4. XM_021471714.1 → XP_021327389.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M9PR95
    Conserved Domains (3) summary
    cd00153
    Location:674 → 760
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:259 → 540
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00618
    Location:106 → 189
    RasGEF_N; RasGEF N-terminal motif

  5. XM_021471713.1 → XP_021327388.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PK82
    Conserved Domains (3) summary
    cd00153
    Location:675 → 761
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:259 → 541
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00618
    Location:106 → 189
    RasGEF_N; RasGEF N-terminal motif

  6. XM_021471715.1 → XP_021327390.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X5

    UniProtKB/TrEMBL
    A0A8M9Q1W7
    Conserved Domains (3) summary
    cd00153
    Location:629 → 715
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:211 → 493
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00618
    Location:58 → 141
    RasGEF_N; RasGEF N-terminal motif

  7. XM_021471717.1 → XP_021327392.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X6

    UniProtKB/TrEMBL
    A0A8M9P940
    Conserved Domains (2) summary
    cd00153
    Location:268 → 354
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    cl02485
    Location:47 → 132
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
Nucleotide Protein
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