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BRCA1 BRCA1 DNA repair associated [ Trachypithecus francoisi (Francois's langur) ]

Gene ID: 117066917, updated on 19-Mar-2024

Summary

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Gene symbol
BRCA1
Gene description
BRCA1 DNA repair associated
See related
EnsemblRapid:ENSTFRG00000007567
Gene type
protein coding
RefSeq status
MODEL
Organism
Trachypithecus francoisi
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Colobinae; Trachypithecus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
24
Annotation release Status Assembly Chr Location
100 current Tfra_2.0 (GCF_009764315.1) Unplaced Scaffold NW_022681466.1 (17117637..17218644)

NW_022681466.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene coiled-coil domain containing 200 Neighboring gene transmembrane protein 106A Neighboring gene NBR1 autophagy cargo receptor Neighboring gene Rho family GTPase 2 Neighboring gene vesicle amine transport 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_022681466 Unplaced Scaffold Reference Tfra_2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence of a warfarin-sensitive cancer procoagulant in V2 carcinoma. Roncaglioni MC, et al. Haematologica, 1989 Mar-Apr. PMID 2501168
  2. Rapid evolution of BRCA1 and BRCA2 in humans and other primates. Lou DI, et al. BMC Evol Biol, 2014 Jul 11. PMID 25011685, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of BRCA1-BARD1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
breast cancer type 1 susceptibility protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Trachypithecus francoisi Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Tfra_2.0 Primary Assembly

Genomic

  1. NW_022681466.1 Reference Tfra_2.0 Primary Assembly

    Range
    17117637..17218644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_033182854.1 → XP_033038745.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    A0A075VNR5
    Conserved Domains (5) summary
    TIGR00599
    Location:22 → 151
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1653 → 1750
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1545 → 1641
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:345 → 508
    BRCT_assoc; Serine-rich domain associated with BRCT

  2. XM_033182851.1 → XP_033038742.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    A0A075VNR5
    Conserved Domains (5) summary
    TIGR00599
    Location:22 → 151
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1653 → 1750
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1545 → 1641
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:345 → 508
    BRCT_assoc; Serine-rich domain associated with BRCT

  3. XM_033182859.1 → XP_033038750.1  breast cancer type 1 susceptibility protein isoform X5

    Conserved Domains (5) summary
    PRK08581
    Location:188 → 439
    PRK08581; amidase domain-containing protein
    TIGR00599
    Location:22 → 151
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:549 → 646
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:441 → 537
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  4. XM_033182858.1 → XP_033038749.1  breast cancer type 1 susceptibility protein isoform X4

    Conserved Domains (4) summary
    TIGR00599
    Location:22 → 151
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:745 → 842
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:637 → 733
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  5. XM_033182860.1 → XP_033038751.1  breast cancer type 1 susceptibility protein isoform X6

    Conserved Domains (4) summary
    TIGR00599
    Location:22 → 151
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:510 → 607
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:402 → 498
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  6. XM_033182855.1 → XP_033038746.1  breast cancer type 1 susceptibility protein isoform X2

    UniProtKB/TrEMBL
    A0A075VNR5
    Conserved Domains (4) summary
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1652 → 1749
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1544 → 1640
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:344 → 507
    BRCT_assoc; Serine-rich domain associated with BRCT

  7. XM_033182856.1 → XP_033038747.1  breast cancer type 1 susceptibility protein isoform X3

    UniProtKB/TrEMBL
    A0A075VNR5
    Conserved Domains (3) summary
    cd17721
    Location:1606 → 1703
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1498 → 1594
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:298 → 461
    BRCT_assoc; Serine-rich domain associated with BRCT

  8. XM_033182852.1 → XP_033038743.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    A0A075VNR5
    Related
    ENSTFRP00000008916.1, ENSTFRT00000011144.1
    Conserved Domains (5) summary
    TIGR00599
    Location:22 → 151
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1653 → 1750
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1545 → 1641
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:345 → 508
    BRCT_assoc; Serine-rich domain associated with BRCT

  9. XM_033182853.1 → XP_033038744.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    A0A075VNR5
    Conserved Domains (5) summary
    TIGR00599
    Location:22 → 151
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1653 → 1750
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1545 → 1641
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:345 → 508
    BRCT_assoc; Serine-rich domain associated with BRCT
Nucleotide Protein
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