rack-1 Small ribosomal subunit protein RACK1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: rack-1
Gene description: Small ribosomal subunit protein RACK1
Locus tag: CELE_K04D7.1
See related: AllianceGenome:WB:WBGene00010556
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein kinase C binding activity and ribosome binding activity. Involved in several processes, including cytoskeleton-dependent cytokinesis; defense response to fungus; and motor neuron axon guidance. Located in several cellular components, including centrosome; growth cone; and kinetochore. Is expressed in anterior distal tip cell; neurons; and posterior distal tip cell. Orthologous to human RACK1 (receptor for activated C kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See rack-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 4

Sequence:: Chromosome: IV; NC_003282.8 (10176680..10177875)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study unveils novel defense mechanisms exist for C. elegans in facilitating enhanced immunity by RACK-1 against Shigella flexneri infection
Title: RACK-1, a multifaceted regulator is required for C. elegans innate immunity against S. flexneri M9OT infection.
Lactobacillus casei pretreatment triggers the TLR mediated and rack-1 dependent p38 MAPK signaling pathway in nematodes. rack-1 is necessary in activating the p38 MAPK pathway by Lactobacillus casei.
Title: Lactobacillus casei triggers a TLR mediated RACK-1 dependent p38 MAPK pathway in Caenorhabditis elegans to resist Klebsiella pneumoniae infection.
RACK-1 controls the biogenesis of a subset of miRNAs, including let-7, and in this way plays a role in the heterochronic gene pathway during C. elegans development.
Title: RACK-1 regulates let-7 microRNA expression and terminal cell differentiation in Caenorhabditis elegans.
RACK1 can contribute to the recruitment of miRISC to the site of translation, and support a post-initiation mode of miRNA-mediated gene repression.
Title: The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans.
show that depletion of Caenorhabditis elegans RACK-1, which leads to short astral microtubules during prometaphase, specifically affects maintenance of cortical PAR domains and Dynamin localization
Title: Long astral microtubules and RACK-1 stabilize polarity domains during maintenance phase in Caenorhabditis elegans embryos.
These studies pinpoint RACK-1 as a component of a novel signaling pathway involving Rac GTPases and UNC-115/abLIM.
Title: RACK-1 acts with Rac GTPase signaling and UNC-115/abLIM in Caenorhabditis elegans axon pathfinding and cell migration.
suggest a mechanism by which RACK-1 directs the dynactin-dependent redistribution of recycling endosomes during the cell cycle
Title: RACK-1 directs dynactin-dependent RAB-11 endosomal recycling during mitosis in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K04D7.1 (e-PCR)
- UniSTS:307761

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables translation regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antifungal innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polar body extrusion after meiotic divisions	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to organelle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in rescue of stalled ribosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Small ribosomal subunit protein RACK1

NP_501859.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10176680..10177875

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069458.7 → NP_501859.1 Small ribosomal subunit protein RACK1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501859.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21215

Conserved Domains (3) summary

COG2319
Location:2 → 317

WD40; WD40 repeat [General function prediction only]

cd00200
Location:8 → 318

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:73 → 109

7WD40; WD40 repeat [structural motif]