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Frmd4a FERM domain containing 4A [ Mus musculus (house mouse) ]

Gene ID: 209630, updated on 23-Jun-2021

Summary

Official Symbol
Frmd4aprovided by MGI
Official Full Name
FERM domain containing 4Aprovided by MGI
Primary source
MGI:MGI:1919850
See related
Ensembl:ENSMUSG00000026657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Frmd4; Gm13190; AI594879; mKIAA1294; 5330420J21; 2700017I06Rik; C230040M21Rik
Expression
Broad expression in CNS E18 (RPKM 13.2), whole brain E14.5 (RPKM 12.1) and 26 other tissues See more
Orthologs
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Genomic context

See Frmd4a in Genome Data Viewer
Location:
2; 2 A1
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (4022461..4618854)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (4017650..4614043)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (4073909..4535089)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 107, member B Neighboring gene predicted gene, 36031 Neighboring gene RIKEN cDNA 1700080N15 gene Neighboring gene polypyrimidine tract-binding protein 1 pseudogene Neighboring gene UPF0688 protein C1orf174 homolog pseudogene Neighboring gene VISTA enhancer mm1695 Neighboring gene uncharacterized LOC102639987 Neighboring gene predicted gene, 39752 Neighboring gene VISTA enhancer mm418 Neighboring gene VISTA enhancer mm28 Neighboring gene VISTA enhancer mm419 Neighboring gene VISTA enhancer mm420 Neighboring gene predicted gene, 23691 Neighboring gene predicted gene, 39751 Neighboring gene VISTA enhancer mm422 Neighboring gene VISTA enhancer mm423 Neighboring gene predicted gene 13179 Neighboring gene pre-mRNA processing factor 18 Neighboring gene ribosomal protein L22 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
FERM domain-containing protein 4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177843.1NP_001171314.1  FERM domain-containing protein 4A isoform 2

    See identical proteins and their annotated locations for NP_001171314.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK082365, BC082808, BP768112
    Consensus CDS
    CCDS50488.1
    UniProtKB/Swiss-Prot
    Q8BIE6
    Related
    ENSMUSP00000075172.8, ENSMUST00000075767.14
    Conserved Domains (4) summary
    smart00295
    Location:6206
    B41; Band 4.1 homologues
    cd13191
    Location:202312
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd17200
    Location:391
    FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
    pfam11819
    Location:341475
    DUF3338; Domain of unknown function (DUF3338)
  2. NM_001177844.1NP_001171315.1  FERM domain-containing protein 4A isoform 3

    See identical proteins and their annotated locations for NP_001171315.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK171532, BC082808, BP768112, CJ101444
    Consensus CDS
    CCDS57151.1
    UniProtKB/TrEMBL
    Q3TB04
    Related
    ENSMUSP00000134803.2, ENSMUST00000176828.8
    Conserved Domains (2) summary
    pfam11819
    Location:75182
    DUF3338; Domain of unknown function (DUF3338)
    cl17171
    Location:118
    PH-like; Pleckstrin homology-like domain
  3. NM_001347086.1NP_001334015.1  FERM domain-containing protein 4A isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences compared to variant 1. The encoded protein has unique N- and C-termini compared to isoform 1.
    Source sequence(s)
    AL807832, AL845441, AL928947
    Consensus CDS
    CCDS84466.1
    UniProtKB/TrEMBL
    H3BIZ7
    Related
    ENSMUSP00000134788.2, ENSMUST00000177457.8
    Conserved Domains (4) summary
    smart00295
    Location:21221
    B41; Band 4.1 homologues
    cd13191
    Location:217327
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd17200
    Location:18106
    FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
    pfam11819
    Location:356490
    DUF3338; Domain of unknown function (DUF3338)
  4. NM_172475.3NP_766063.3  FERM domain-containing protein 4A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC058672, BC082808, BP768112, BY138785
    Consensus CDS
    CCDS15656.2
    UniProtKB/Swiss-Prot
    Q8BIE6
    Related
    ENSMUSP00000089079.5, ENSMUST00000091497.11
    Conserved Domains (3) summary
    smart00295
    Location:17217
    B41; Band 4.1 homologues
    cd13191
    Location:213323
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    pfam11819
    Location:379486
    DUF3338; Domain of unknown function (DUF3338)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    4022461..4618854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497439.4XP_006497502.1  FERM domain-containing protein 4A isoform X4

    Conserved Domains (4) summary
    smart00295
    Location:21221
    B41; Band 4.1 homologues
    cd13191
    Location:217327
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd17200
    Location:18106
    FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
    pfam11819
    Location:356490
    DUF3338; Domain of unknown function (DUF3338)
  2. XM_036160208.1XP_036016101.1  FERM domain-containing protein 4A isoform X5

    Conserved Domains (4) summary
    smart00295
    Location:17217
    B41; Band 4.1 homologues
    cd13191
    Location:213323
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd17200
    Location:14102
    FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
    pfam11819
    Location:352486
    DUF3338; Domain of unknown function (DUF3338)
  3. XM_006497437.4XP_006497500.1  FERM domain-containing protein 4A isoform X2

    Conserved Domains (4) summary
    smart00295
    Location:28228
    B41; Band 4.1 homologues
    cd13191
    Location:224334
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd17200
    Location:25113
    FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
    pfam11819
    Location:363497
    DUF3338; Domain of unknown function (DUF3338)
  4. XM_006497438.4XP_006497501.1  FERM domain-containing protein 4A isoform X3

    Conserved Domains (4) summary
    smart00295
    Location:36236
    B41; Band 4.1 homologues
    cd13191
    Location:232342
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd17200
    Location:33121
    FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
    pfam11819
    Location:371505
    DUF3338; Domain of unknown function (DUF3338)
  5. XM_006497436.4XP_006497499.1  FERM domain-containing protein 4A isoform X1

    Conserved Domains (4) summary
    smart00295
    Location:36236
    B41; Band 4.1 homologues
    cd13191
    Location:232342
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd17200
    Location:33121
    FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
    pfam11819
    Location:371505
    DUF3338; Domain of unknown function (DUF3338)
  6. XM_006497443.4XP_006497506.1  FERM domain-containing protein 4A isoform X8

    Conserved Domains (4) summary
    smart00295
    Location:36236
    B41; Band 4.1 homologues
    cd13191
    Location:232342
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd17200
    Location:33121
    FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
    pfam11819
    Location:371505
    DUF3338; Domain of unknown function (DUF3338)
  7. XM_006497441.2XP_006497504.1  FERM domain-containing protein 4A isoform X6

    See identical proteins and their annotated locations for XP_006497504.1

    UniProtKB/Swiss-Prot
    Q8BIE6
    Conserved Domains (4) summary
    smart00295
    Location:6206
    B41; Band 4.1 homologues
    cd13191
    Location:202312
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd17200
    Location:391
    FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
    pfam11819
    Location:341475
    DUF3338; Domain of unknown function (DUF3338)
  8. XM_030249169.2XP_030105029.1  FERM domain-containing protein 4A isoform X7

    Conserved Domains (4) summary
    smart00295
    Location:6206
    B41; Band 4.1 homologues
    cd13191
    Location:202312
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd17200
    Location:391
    FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
    pfam11819
    Location:341475
    DUF3338; Domain of unknown function (DUF3338)
  9. XM_006497442.3XP_006497505.1  FERM domain-containing protein 4A isoform X6

    See identical proteins and their annotated locations for XP_006497505.1

    UniProtKB/Swiss-Prot
    Q8BIE6
    Conserved Domains (4) summary
    smart00295
    Location:6206
    B41; Band 4.1 homologues
    cd13191
    Location:202312
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd17200
    Location:391
    FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
    pfam11819
    Location:341475
    DUF3338; Domain of unknown function (DUF3338)
  10. XM_006497440.1XP_006497503.1  FERM domain-containing protein 4A isoform X6

    See identical proteins and their annotated locations for XP_006497503.1

    UniProtKB/Swiss-Prot
    Q8BIE6
    Conserved Domains (4) summary
    smart00295
    Location:6206
    B41; Band 4.1 homologues
    cd13191
    Location:202312
    FERM_C_FRMD4A_FRMD4B; FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B)
    cd17200
    Location:391
    FERM_F1_FRMD4B; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM domain-containing protein 4B (FRMD4B)
    pfam11819
    Location:341475
    DUF3338; Domain of unknown function (DUF3338)
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