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Tmprss13 transmembrane serine protease 13 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300682, updated on 6-Jun-2024

Summary

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Official Symbol
Tmprss13provided by RGD
Official Full Name
transmembrane serine protease 13provided by RGD
Primary source
RGD:1310872
See related
Ensembl:ENSRNOG00000016397 AllianceGenome:RGD:1310872
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310872
Summary
Predicted to enable scavenger receptor activity and serine-type endopeptidase activity. Predicted to be involved in endocytosis and proteolysis. Predicted to act upstream of or within establishment of skin barrier. Predicted to be integral component of membrane. Orthologous to human TMPRSS13 (transmembrane serine protease 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 51.8) See more
Orthologs
human mouse all
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Genomic context

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See Tmprss13 in Genome Data Viewer
Location:
8q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (54522069..54550673)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (45625759..45653943)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (49621568..49650863)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene interleukin 10 receptor subunit alpha Neighboring gene glutathione S-transferase pi 1, pseudogene 4 Neighboring gene uncharacterized LOC120094137 Neighboring gene FXYD domain-containing ion transport regulator 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TMPRSS13 deficiency impairs stratum corneum formation and epidermal barrier acquisition. Madsen DH, et al. Biochem J, 2014 Aug 1. PMID 24832573, Free PMC Article
  2. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within establishment of skin barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protease serine 13
Names
transmembrane protease, serine 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127528.2 → NP_001121000.1  transmembrane protease serine 13

    See identical proteins and their annotated locations for NP_001121000.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6AUK0, B2RYJ5
    Related
    ENSRNOP00000021949.5, ENSRNOT00000021949.6
    Conserved Domains (5) summary
    smart00020
    Location:297 → 526
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:298 → 526
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00530
    Location:216 → 288
    SRCR; Scavenger receptor cysteine-rich domain
    pfam15494
    Location:203 → 292
    SRCR_2; Scavenger receptor cysteine-rich domain
    cl23807
    Location:1 → 69
    WWbp; WW-domain ligand protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    54522069..54550673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265112.1 → XP_063121182.1  transmembrane protease serine 13 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AUK0, F7FMG3
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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