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Ibtk inhibitor of Bruton tyrosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 315858, updated on 13-Apr-2024

Summary

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Official Symbol
Ibtkprovided by RGD
Official Full Name
inhibitor of Bruton tyrosine kinaseprovided by RGD
Primary source
RGD:1311697
See related
Ensembl:ENSRNOG00000027728 AllianceGenome:RGD:1311697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein kinase binding activity and protein tyrosine kinase inhibitor activity. Predicted to be involved in negative regulation of protein phosphorylation. Predicted to act upstream of or within release of sequestered calcium ion into cytosol. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human IBTK (inhibitor of Bruton tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 244.0), Spleen (RPKM 186.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q31
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (95505630..95579435, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (86625591..86698661, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (93323454..93397044, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene terminal nucleotidyltransferase 5A Neighboring gene uncharacterized LOC120094217 Neighboring gene family with sequence similarity 162, member A, pseudogene 1 Neighboring gene quinolinate phosphoribosyltransferase, pseudogene 1 Neighboring gene ribosomal protein S20 like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein. Liu W, et al. Nat Immunol, 2001 Oct. PMID 11577348
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inhibitor of Bruton tyrosine kinase
Names
inhibitor of Bruton agammaglobulinemia tyrosine kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427757.1 → NP_001414686.1  inhibitor of Bruton tyrosine kinase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I1T2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    95505630..95579435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082545.2 → XP_038938473.1  inhibitor of Bruton tyrosine kinase isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUJ7, D3ZH46
    Related
    ENSRNOP00000081930.1
    Conserved Domains (7) summary
    COG5184
    Location:139 → 341
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    sd00045
    Location:51 → 82
    ANK; ANK repeat [structural motif]
    cd18301
    Location:546 → 651
    BTB1_POZ_IBtk; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    cd18302
    Location:763 → 875
    BTB2_POZ_IBtk; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    cd18500
    Location:871 → 930
    BACK_IBtk; BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    pfam00415
    Location:247 → 299
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam12796
    Location:45 → 116
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_039082547.2 → XP_038938475.1  inhibitor of Bruton tyrosine kinase isoform X4

    Conserved Domains (3) summary
    cd18301
    Location:1 → 92
    BTB1_POZ_IBtk; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    cd18302
    Location:204 → 316
    BTB2_POZ_IBtk; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    cd18500
    Location:312 → 371
    BACK_IBtk; BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk)

  3. XM_063265559.1 → XP_063121629.1  inhibitor of Bruton tyrosine kinase isoform X3

  4. XM_039082546.2 → XP_038938474.1  inhibitor of Bruton tyrosine kinase isoform X2

    UniProtKB/TrEMBL
    A6I1T3
    Conserved Domains (6) summary
    COG5184
    Location:139 → 341
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    sd00045
    Location:51 → 82
    ANK; ANK repeat [structural motif]
    cd18301
    Location:547 → 652
    BTB1_POZ_IBtk; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    cd18302
    Location:764 → 870
    BTB2_POZ_IBtk; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    pfam00415
    Location:247 → 299
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam12796
    Location:45 → 116
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version

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