wdr3 WD repeat domain 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wdr3provided by ZNC
Official Full Name: WD repeat domain 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9830
See related: Ensembl:ENSDARG00000011079 AllianceGenome:ZFIN:ZDB-GENE-030131-9830
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb42; wu:fb92b07
Summary: Predicted to enable snoRNA binding activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; midbrain; and retina. Human ortholog(s) of this gene implicated in thyroid gland papillary carcinoma. Orthologous to human WDR3 (WD repeat domain 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (20853908..20872565)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (21043039..21061696)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI584849 (e-PCR)
- UniSTS:206221

AI584326 (e-PCR)
- UniSTS:206248

fb83e09.x1 (e-PCR)
- UniSTS:191725

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables snoRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in maturation of SSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Pwp2p-containing subcomplex of 90S preribosome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198873.1 → NP_942574.1 WD repeat-containing protein 3

See identical proteins and their annotated locations for NP_942574.1

Status: PROVISIONAL

Source sequence(s)

BC057490

UniProtKB/TrEMBL

Q6PFM8

Related

ENSDARP00000023281.8, ENSDART00000003648.10

Conserved Domains (5) summary

COG2319
Location:57 → 692

WD40; WD40 repeat [General function prediction only]

cd00200
Location:400 → 697

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam04003
Location:799 → 900

Utp12; Dip2/Utp12 Family

sd00039
Location:452 → 487

7WD40; WD40 repeat [structural motif]

cl02567
Location:35 → 136

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...