rempA reduced mechanoreceptor potential A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: rempAprovided by FlyBase
Official Full Name: reduced mechanoreceptor potential Aprovided by FlyBase
Primary source: FLYBASE:FBgn0260933
Locus tag: Dmel_CG11838
See related: AllianceGenome:FB:FBgn0260933
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11838; Che-11; CHE-11; Dmel\CG11838; IFT140; IFT40; OSEG; oseg3; Oseg3; OSEG3; remp; RempA; REMPA
Summary: Involved in several processes, including non-motile cilium assembly; positive regulation of protein import into nucleus; and transport along microtubule. Located in non-motile cilium. Is expressed in antenno-maxillary complex; sensory mother cell; sensory neurons; and spermatozoon. Human ortholog(s) of this gene implicated in retinitis pigmentosa and short-rib thoracic dysplasia 9 with or without polydactyly. Orthologous to human IFT140 (intraflagellar transport 140). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 21E2-21E2; 2-1.5 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (553742..560310, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (553742..560310, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IEP Inferred from Expression Pattern more info	PubMed
involved_in intraciliary retrograde transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intraciliary retrograde transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-motile cilium assembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein import into nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein transport along microtubule	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle A	IBA Inferred from Biological aspect of Ancestor more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: reduced mechanoreceptor potential A

Names: CG11838-PB; CG11838-PC; Oseg3; RempA; reduced mechanoreceptor potentials; reduced mechanoreceptor potentials A; rempA-PB; rempA-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

553742..560310 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_134686.2 → NP_608530.2 reduced mechanoreceptor potential A, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608530.2

Status: REVIEWED

UniProtKB/TrEMBL

Q1EC86, Q5BI64, Q9VPR0

Conserved Domains (4) summary

COG0457
Location:815 → 1025

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

COG2319
Location:26 → 435

WD40; WD40 repeat [General function prediction only]

sd00006
Location:892 → 928

TPR; TPR repeat [structural motif]

cl14649
Location:856 → 1065

BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains
NM_205886.2 → NP_995608.1 reduced mechanoreceptor potential A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995608.1

Status: REVIEWED

UniProtKB/TrEMBL

Q1EC86, Q7KTZ4

Conserved Domains (6) summary

COG0457
Location:860 → 1070

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

COG2319
Location:71 → 480

WD40; WD40 repeat [General function prediction only]

sd00006
Location:937 → 973

TPR; TPR repeat [structural motif]

sd00039
Location:67 → 103

7WD40; WD40 repeat [structural motif]

cl02567
Location:14 → 123

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl14649
Location:901 → 1110

BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains