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nudc nudC nuclear distribution protein [ Danio rerio (zebrafish) ]

Gene ID: 393893, updated on 19-Jun-2024

Summary

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Official Symbol
nudcprovided by ZNC
Official Full Name
nudC nuclear distribution proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-899
See related
Ensembl:ENSDARG00000104837 AllianceGenome:ZFIN:ZDB-GENE-040426-899
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56099; zgc:85670
Summary
Predicted to enable unfolded protein binding activity. Acts upstream of or within cilium assembly and determination of heart left/right asymmetry. Predicted to be located in microtubule. Predicted to be active in cytoplasm. Orthologous to human NUDC (nuclear distribution C, dynein complex regulator). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See nudc in Genome Data Viewer
Location:
chromosome: 19
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (14158095..14169460)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (14295900..14307265)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene keratinocyte differentiation factor 1b Neighboring gene nuclear receptor subfamily 0, group B, member 2b Neighboring gene T-box transcription factor Ta Neighboring gene AT-rich interactive domain 1Ab

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1. Zhang C, et al. Cell Res, 2016 Feb. PMID 26704451, Free PMC Article
  2. Efficient disruption of Zebrafish genes using a Gal4-containing gene trap. Balciuniene J, et al. BMC Genomics, 2013 Sep 14. PMID 24034702, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC56099

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cilium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within determination of heart left/right asymmetry IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear migration protein nudC
Names
nuclear distribution gene C homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200919.1 → NP_957213.1  nuclear migration protein nudC

    See identical proteins and their annotated locations for NP_957213.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045909
    UniProtKB/TrEMBL
    Q7ZVD2
    Related
    ENSDARP00000136053.1, ENSDART00000170335.2
    Conserved Domains (3) summary
    cd06492
    Location:174 → 260
    p23_mNUDC_like; p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) ...
    pfam14050
    Location:7 → 57
    Nudc_N; N-terminal conserved domain of Nudc
    pfam16273
    Location:100 → 158
    NuDC; Nuclear distribution C domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    14158095..14169460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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