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GSAP gamma-secretase activating protein [ Canis lupus familiaris (dog) ]

Gene ID: 475903, updated on 5-Mar-2024

Summary

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Official Symbol
GSAPprovided by VGNC
Official Full Name
gamma-secretase activating proteinprovided by VGNC
Primary source
VGNC:VGNC:41524
See related
Ensembl:ENSCAFG00845021366
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
PION
Orthologs
human mouse all
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Genomic context

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See GSAP in Genome Data Viewer
Location:
chromosome: 18
Exon count:
34
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (17728145..17811342, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (17065522..17150068, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (17686332..17770275, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (17478408..17561728, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (17417391..17501091, complement)

Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 185 member A Neighboring gene coiled-coil domain containing 146 Neighboring gene fibrinogen like 2 Neighboring gene uncharacterized LOC102154601 Neighboring gene uncharacterized LOC119864103

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in positive regulation of amyloid-beta formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
LOW QUALITY PROTEIN: gamma-secretase-activating protein; gamma-secretase-activating protein
Names
pigeon homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051822.1 Reference ROS_Cfam_1.0

    Range
    17728145..17811342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038423877.1 → XP_038279805.1  gamma-secretase-activating protein isoform X4

    UniProtKB/TrEMBL
    A0A8C0SZ72
    Conserved Domains (1) summary
    pfam14959
    Location:642 → 707
    GSAP-16; gamma-Secretase-activating protein C-term

  2. XM_038423875.1 → XP_038279803.1  gamma-secretase-activating protein isoform X2

    UniProtKB/TrEMBL
    A0A8I3P7W8
    Related
    ENSCAFP00845029853.1, ENSCAFT00845038106.1
    Conserved Domains (1) summary
    pfam14959
    Location:642 → 747
    GSAP-16; gamma-Secretase-activating protein C-term

  3. XM_038423876.1 → XP_038279804.1  gamma-secretase-activating protein isoform X3

    UniProtKB/TrEMBL
    A0A8C0SZ72
    Conserved Domains (1) summary
    pfam14959
    Location:642 → 708
    GSAP-16; gamma-Secretase-activating protein C-term

  4. XM_038423874.1 → XP_038279802.1  gamma-secretase-activating protein isoform X1

    UniProtKB/TrEMBL
    A0A8I3P7W8
    Related
    ENSCAFP00845029557.1, ENSCAFT00845037722.1
    Conserved Domains (1) summary
    pfam14959
    Location:642 → 748
    GSAP-16; gamma-Secretase-activating protein C-term

  5. XM_038423883.1 → XP_038279811.1  gamma-secretase-activating protein isoform X9

    UniProtKB/TrEMBL
    A0A8C0SV75, A0A8I3PMH1
    Conserved Domains (1) summary
    pfam14959
    Location:495 → 601
    GSAP-16; gamma-Secretase-activating protein C-term

  6. XM_038423884.1 → XP_038279812.1  gamma-secretase-activating protein isoform X10

    UniProtKB/TrEMBL
    A0A8C0LAY1
    Conserved Domains (1) summary
    pfam14959
    Location:427 → 533
    GSAP-16; gamma-Secretase-activating protein C-term

  7. XM_038423879.1 → XP_038279807.1  gamma-secretase-activating protein isoform X6

    UniProtKB/TrEMBL
    A0A8C0SZ72
    Conserved Domains (1) summary
    pfam14959
    Location:642 → 695
    GSAP-16; gamma-Secretase-activating protein C-term

  8. XM_038423878.1 → XP_038279806.1  gamma-secretase-activating protein isoform X5

    UniProtKB/TrEMBL
    A0A8C0SZ72
    Conserved Domains (1) summary
    pfam14959
    Location:642 → 696
    GSAP-16; gamma-Secretase-activating protein C-term

  9. XM_038423882.1 → XP_038279810.1  gamma-secretase-activating protein isoform X8

    UniProtKB/TrEMBL
    A0A8C0SZ72
    Conserved Domains (1) summary
    pfam14959
    Location:642 → 694
    GSAP-16; gamma-Secretase-activating protein C-term

  10. XM_038423881.1 → XP_038279809.1  gamma-secretase-activating protein isoform X7

    UniProtKB/TrEMBL
    A0A8C0SZ72
    Conserved Domains (1) summary
    pfam14959
    Location:642 → 695
    GSAP-16; gamma-Secretase-activating protein C-term

RNA

  1. XR_005296279.1 RNA Sequence

    Related
    ENSCAFT00845038412.1

  2. XR_005296278.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049278.1 Alternate UMICH_Zoey_3.1

    Range
    17478408..17561728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038500237.1 → XP_038356165.1  gamma-secretase-activating protein isoform X4

  2. XM_038500234.1 → XP_038356162.1  gamma-secretase-activating protein isoform X2

  3. XM_038500235.1 → XP_038356163.1  gamma-secretase-activating protein isoform X3

  4. XM_038500233.1 → XP_038356161.1  gamma-secretase-activating protein isoform X1

  5. XM_038500242.1 → XP_038356170.1  gamma-secretase-activating protein isoform X9

    Conserved Domains (1) summary
    pfam14959
    Location:495 → 601
    GSAP-16; gamma-Secretase-activating protein C-term

  6. XM_038500243.1 → XP_038356171.1  gamma-secretase-activating protein isoform X10

    Conserved Domains (1) summary
    pfam14959
    Location:427 → 533
    GSAP-16; gamma-Secretase-activating protein C-term

  7. XM_038500239.1 → XP_038356167.1  gamma-secretase-activating protein isoform X6

  8. XM_038500238.1 → XP_038356166.1  gamma-secretase-activating protein isoform X5

  9. XM_038500241.1 → XP_038356169.1  gamma-secretase-activating protein isoform X8

  10. XM_038500240.1 → XP_038356168.1  gamma-secretase-activating protein isoform X7

RNA

  1. XR_005339416.1 RNA Sequence

  2. XR_005339415.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

    Range
    17417391..17501091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038626903.1 → XP_038482831.1  gamma-secretase-activating protein isoform X4

    Conserved Domains (1) summary
    pfam14959
    Location:642 → 707
    GSAP-16; gamma-Secretase-activating protein C-term

  2. XM_038626901.1 → XP_038482829.1  gamma-secretase-activating protein isoform X2

    Conserved Domains (1) summary
    pfam14959
    Location:642 → 747
    GSAP-16; gamma-Secretase-activating protein C-term

  3. XM_038626902.1 → XP_038482830.1  gamma-secretase-activating protein isoform X3

    Conserved Domains (1) summary
    pfam14959
    Location:642 → 708
    GSAP-16; gamma-Secretase-activating protein C-term

  4. XM_038626900.1 → XP_038482828.1  gamma-secretase-activating protein isoform X1

    Conserved Domains (1) summary
    pfam14959
    Location:642 → 748
    GSAP-16; gamma-Secretase-activating protein C-term

  5. XM_038626908.1 → XP_038482836.1  gamma-secretase-activating protein isoform X9

    Conserved Domains (1) summary
    pfam14959
    Location:495 → 601
    GSAP-16; gamma-Secretase-activating protein C-term

  6. XM_038626909.1 → XP_038482837.1  gamma-secretase-activating protein isoform X10

    Conserved Domains (1) summary
    pfam14959
    Location:427 → 533
    GSAP-16; gamma-Secretase-activating protein C-term

  7. XM_038626905.1 → XP_038482833.1  gamma-secretase-activating protein isoform X6

    Conserved Domains (1) summary
    pfam14959
    Location:642 → 695
    GSAP-16; gamma-Secretase-activating protein C-term

  8. XM_038626904.1 → XP_038482832.1  gamma-secretase-activating protein isoform X5

    Conserved Domains (1) summary
    pfam14959
    Location:642 → 696
    GSAP-16; gamma-Secretase-activating protein C-term

  9. XM_038626907.1 → XP_038482835.1  gamma-secretase-activating protein isoform X8

    Conserved Domains (1) summary
    pfam14959
    Location:642 → 694
    GSAP-16; gamma-Secretase-activating protein C-term

  10. XM_038626906.1 → XP_038482834.1  gamma-secretase-activating protein isoform X7

    Conserved Domains (1) summary
    pfam14959
    Location:642 → 695
    GSAP-16; gamma-Secretase-activating protein C-term

RNA

  1. XR_005407261.1 RNA Sequence

  2. XR_005407260.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

    Range
    17686332..17770275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038562789.1 → XP_038418717.1  LOW QUALITY PROTEIN: gamma-secretase-activating protein isoform X1

    UniProtKB/TrEMBL
    A0A8I3P7W8, A0A8P0STB6

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    17065522..17150068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038454171.1 → XP_038310099.1  gamma-secretase-activating protein isoform X4

    UniProtKB/TrEMBL
    A0A8C0SZ72
    Conserved Domains (1) summary
    pfam14959
    Location:642 → 707
    GSAP-16; gamma-Secretase-activating protein C-term

  2. XM_038454169.1 → XP_038310097.1  gamma-secretase-activating protein isoform X2

    UniProtKB/TrEMBL
    A0A8P0STB6
    Conserved Domains (1) summary
    pfam14959
    Location:642 → 747
    GSAP-16; gamma-Secretase-activating protein C-term

  3. XM_038454170.1 → XP_038310098.1  gamma-secretase-activating protein isoform X3

    UniProtKB/TrEMBL
    A0A8C0SZ72
    Conserved Domains (1) summary
    pfam14959
    Location:642 → 708
    GSAP-16; gamma-Secretase-activating protein C-term

  4. XM_038454168.1 → XP_038310096.1  gamma-secretase-activating protein isoform X1

    UniProtKB/TrEMBL
    A0A8P0STB6
    Conserved Domains (1) summary
    pfam14959
    Location:642 → 748
    GSAP-16; gamma-Secretase-activating protein C-term

  5. XM_038454176.1 → XP_038310104.1  gamma-secretase-activating protein isoform X9

    UniProtKB/TrEMBL
    A0A8P0N744
    Conserved Domains (1) summary
    pfam14959
    Location:495 → 601
    GSAP-16; gamma-Secretase-activating protein C-term

  6. XM_022405241.2 → XP_022260949.1  gamma-secretase-activating protein isoform X10

    UniProtKB/TrEMBL
    A0A8C0LAY1
    Conserved Domains (1) summary
    pfam14959
    Location:427 → 533
    GSAP-16; gamma-Secretase-activating protein C-term

  7. XM_038454173.1 → XP_038310101.1  gamma-secretase-activating protein isoform X6

    UniProtKB/TrEMBL
    A0A8C0SZ72
    Conserved Domains (1) summary
    pfam14959
    Location:642 → 695
    GSAP-16; gamma-Secretase-activating protein C-term

  8. XM_038454172.1 → XP_038310100.1  gamma-secretase-activating protein isoform X5

    UniProtKB/TrEMBL
    A0A8C0SZ72
    Conserved Domains (1) summary
    pfam14959
    Location:642 → 696
    GSAP-16; gamma-Secretase-activating protein C-term

  9. XM_038454175.1 → XP_038310103.1  gamma-secretase-activating protein isoform X8

    UniProtKB/TrEMBL
    A0A8C0SZ72
    Conserved Domains (1) summary
    pfam14959
    Location:642 → 694
    GSAP-16; gamma-Secretase-activating protein C-term

  10. XM_038454174.1 → XP_038310102.1  gamma-secretase-activating protein isoform X7

    UniProtKB/TrEMBL
    A0A8C0SZ72
    Conserved Domains (1) summary
    pfam14959
    Location:642 → 695
    GSAP-16; gamma-Secretase-activating protein C-term

RNA

  1. XR_005311751.1 RNA Sequence

  2. XR_005311750.1 RNA Sequence

Nucleotide Protein
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