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CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase [ Canis lupus familiaris (dog) ]

Gene ID: 483009, updated on 5-Mar-2024

Summary

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Official Symbol
CADprovided by VGNC
Official Full Name
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotaseprovided by VGNC
Primary source
VGNC:VGNC:106593
See related
Ensembl:ENSCAFG00845006464
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See CAD in Genome Data Viewer
Location:
chromosome: 17
Exon count:
46
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 17 NC_051821.1 (21519811..21542872)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 17 NC_006599.4 (21090639..21113701)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 17 NC_049238.1 (21264518..21287583)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 17 NC_049277.1 (21206567..21229628)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 17 NC_049758.1 (21217636..21240698)

Chromosome 17 - NC_051821.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene solute carrier family 5 member 6 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene solute carrier family 30 member 3 Neighboring gene uncharacterized LOC119869803

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables amino acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables aspartate carbamoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of carbamoyl-phosphate synthase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
CAD protein
XP_005630306.1
XP_038308906.1
XP_038354433.1
XP_038354434.1
XP_038354435.1
XP_038416985.1
XP_038416986.1
XP_038416987.1
XP_038481035.1
XP_038481036.1
XP_038481037.1
XP_038546934.1
XP_038546935.1
XP_038546936.1
XP_540124.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051821.1 Reference ROS_Cfam_1.0

    Range
    21519811..21542872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038691008.1 → XP_038546936.1  CAD protein isoform X3

    UniProtKB/TrEMBL
    A0A8C0QFL7
    Related
    ENSCAFP00845009008.1, ENSCAFT00845011530.1
    Conserved Domains (4) summary
    PLN02527
    Location:1914 → 2213
    PLN02527; aspartate carbamoyltransferase
    PRK12564
    Location:2 → 328
    PRK12564; carbamoyl-phosphate synthase small subunit
    cd01316
    Location:1433 → 1779
    CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
    TIGR01369
    Location:364 → 1413
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit

  2. XM_038691006.1 → XP_038546934.1  CAD protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0LIV4
    Conserved Domains (4) summary
    PLN02527
    Location:1941 → 2240
    PLN02527; aspartate carbamoyltransferase
    PRK12564
    Location:1 → 355
    PRK12564; carbamoyl-phosphate synthase small subunit
    cd01316
    Location:1460 → 1806
    CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
    TIGR01369
    Location:391 → 1440
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit

  3. XM_038691007.1 → XP_038546935.1  CAD protein isoform X2

    UniProtKB/TrEMBL
    A0A8C0LIV4
    Related
    ENSCAFP00845009162.1, ENSCAFT00845011738.1
    Conserved Domains (4) summary
    PLN02527
    Location:1924 → 2223
    PLN02527; aspartate carbamoyltransferase
    PRK12564
    Location:1 → 355
    PRK12564; carbamoyl-phosphate synthase small subunit
    cd01316
    Location:1460 → 1806
    CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
    TIGR01369
    Location:391 → 1440
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049277.1 Alternate UMICH_Zoey_3.1

    Range
    21206567..21229628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038498507.1 → XP_038354435.1  CAD protein isoform X3

    Conserved Domains (4) summary
    PLN02527
    Location:1914 → 2213
    PLN02527; aspartate carbamoyltransferase
    PRK12564
    Location:2 → 328
    PRK12564; carbamoyl-phosphate synthase small subunit
    cd01316
    Location:1433 → 1779
    CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
    TIGR01369
    Location:364 → 1413
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit

  2. XM_038498505.1 → XP_038354433.1  CAD protein isoform X1

  3. XM_038498506.1 → XP_038354434.1  CAD protein isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049758.1 Alternate UNSW_CanFamBas_1.0

    Range
    21217636..21240698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038625109.1 → XP_038481037.1  CAD protein isoform X3

    Conserved Domains (4) summary
    PLN02527
    Location:1914 → 2213
    PLN02527; aspartate carbamoyltransferase
    PRK12564
    Location:2 → 328
    PRK12564; carbamoyl-phosphate synthase small subunit
    cd01316
    Location:1433 → 1779
    CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
    TIGR01369
    Location:364 → 1413
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit

  2. XM_038625107.1 → XP_038481035.1  CAD protein isoform X1

  3. XM_038625108.1 → XP_038481036.1  CAD protein isoform X2

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049238.1 Alternate UU_Cfam_GSD_1.0

    Range
    21264518..21287583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038561059.1 → XP_038416987.1  CAD protein isoform X3

    UniProtKB/TrEMBL
    A0A8C0QFL7
    Conserved Domains (4) summary
    PLN02527
    Location:1914 → 2213
    PLN02527; aspartate carbamoyltransferase
    PRK12564
    Location:2 → 328
    PRK12564; carbamoyl-phosphate synthase small subunit
    cd01316
    Location:1433 → 1779
    CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
    TIGR01369
    Location:364 → 1413
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit

  2. XM_038561057.1 → XP_038416985.1  CAD protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0LIV4, A0A8C0MM07, A0A8P0P4F4

  3. XM_038561058.1 → XP_038416986.1  CAD protein isoform X2

    UniProtKB/TrEMBL
    A0A8C0LIV4, A0A8C0QRL7

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006599.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    21090639..21113701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038452978.1 → XP_038308906.1  CAD protein isoform X3

    UniProtKB/TrEMBL
    A0A8C0QFL7
    Conserved Domains (4) summary
    PLN02527
    Location:1914 → 2213
    PLN02527; aspartate carbamoyltransferase
    PRK12564
    Location:2 → 328
    PRK12564; carbamoyl-phosphate synthase small subunit
    cd01316
    Location:1433 → 1779
    CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
    TIGR01369
    Location:364 → 1413
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit

  2. XM_005630249.3 → XP_005630306.1  CAD protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0LIV4, A0A8C0MM07, A0A8P0P4F4
    Conserved Domains (13) summary
    cd01744
    Location:178 → 354
    GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
    PLN02527
    Location:1941 → 2240
    PLN02527; aspartate carbamoyltransferase
    PRK09060
    Location:1429 → 1810
    PRK09060; dihydroorotase; Validated
    PRK12564
    Location:1 → 355
    PRK12564; carbamoyl phosphate synthase small subunit; Reviewed
    cd01316
    Location:1460 → 1806
    CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
    cd01423
    Location:1313 → 1438
    MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
    TIGR01369
    Location:391 → 1440
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
    pfam00185
    Location:2089 → 2238
    OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
    pfam00988
    Location:2 → 138
    CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
    pfam02729
    Location:1942 → 2082
    OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
    pfam02786
    Location:514 → 716
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    pfam02787
    Location:801 → 921
    CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
    cl17255
    Location:1048 → 1245
    ATP-grasp_4; ATP-grasp domain

  3. XM_540124.7 → XP_540124.3  CAD protein isoform X2

    UniProtKB/TrEMBL
    A0A8C0LIV4, A0A8C0QRL7
    Conserved Domains (13) summary
    cd01744
    Location:178 → 354
    GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
    PLN02527
    Location:1924 → 2223
    PLN02527; aspartate carbamoyltransferase
    PRK09060
    Location:1429 → 1810
    PRK09060; dihydroorotase; Validated
    PRK12564
    Location:1 → 355
    PRK12564; carbamoyl phosphate synthase small subunit; Reviewed
    cd01316
    Location:1460 → 1806
    CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
    cd01423
    Location:1313 → 1438
    MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
    TIGR01369
    Location:391 → 1440
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
    pfam00185
    Location:2072 → 2221
    OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
    pfam00988
    Location:2 → 138
    CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
    pfam02729
    Location:1925 → 2065
    OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
    pfam02786
    Location:514 → 716
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    pfam02787
    Location:801 → 921
    CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
    cl17255
    Location:1048 → 1245
    ATP-grasp_4; ATP-grasp domain
Nucleotide Protein
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