masp2 MBL associated serine protease 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: masp2provided by ZNC
Official Full Name: MBL associated serine protease 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-060130-154
See related: Ensembl:ENSDARG00000007988 AllianceGenome:ZFIN:ZDB-GENE-060130-154
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:eu714; wu:fb62a09
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within complement activation, lectin pathway and proteolysis. Predicted to be active in extracellular space. Is expressed in liver. Orthologous to human MASP2 (MBL associated serine protease 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (28770225..28796159)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (28843684..28869618)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within complement activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mannan-binding lectin serine protease 2

Names: mannan-binding lectin serine peptidase 2

NP_001116330.1

EC 3.4.21.104

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122858.1 → NP_001116330.1 mannan-binding lectin serine protease 2 precursor

Status: PROVISIONAL

Source sequence(s)

CR381533

UniProtKB/TrEMBL

A0A8M1NGF4

Related

ENSDARP00000116209.1, ENSDART00000132179.3

Conserved Domains (7) summary

cd00033
Location:362 → 410

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00020
Location:435 → 676

Tryp_SPc; Trypsin-like serine protease

smart00032
Location:296 → 357

CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

smart00042
Location:24 → 130

CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein

smart00179
Location:134 → 176

EGF_CA; Calcium-binding EGF-like domain

cd00190
Location:436 → 679

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00431
Location:180 → 289

CUB; CUB domain