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    Golgb1 golgin B1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192243, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Golgb1provided by RGD
    Official Full Name
    golgin B1provided by RGD
    Primary source
    RGD:708429
    See related
    Ensembl:ENSRNOG00000030314 AllianceGenome:RGD:708429
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in chondrocyte proliferation. Predicted to be located in Golgi apparatus. Predicted to be active in cis-Golgi network and endoplasmic reticulum-Golgi intermediate compartment. Used to study osteochondrodysplasia. Orthologous to human GOLGB1 (golgin B1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 159.9), Lung (RPKM 106.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    11q21
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (77348573..77406165, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (63843179..63900665, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (66761646..66819115, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene F-box protein 40 Neighboring gene hematopoietic cell specific Lyn substrate 1 Neighboring gene IQ motif containing B1 Neighboring gene ELL associated factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Insertional mutation in the Golgb1 gene is associated with osteochondrodysplasia and systemic edema in the OCD rat. Katayama K, et al. Bone, 2011 Nov. PMID 21851869
    2. Giantin Is Required for Post-Alcohol Recovery of Golgi in Liver Cells. Casey CA, et al. Biomolecules, 2018 Nov 16. PMID 30453527, Free PMC Article
    3. Giantin is required for coordinated production of aggrecan, link protein and type XI collagen during chondrogenesis. Katayama K, et al. Biochem Biophys Res Commun, 2018 May 15. PMID 29577904
    4. Characterization of the INT6 mammary tumor gene product. Diella F, et al. DNA Cell Biol, 1997 Jul. PMID 9260927
    5. Subunit composition of the human cytoplasmic dynein-2 complex. Asante D, et al. J Cell Sci, 2014 Nov 1. PMID 25205765, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ethanol-induced Golgi disassembly was associated with de-dimerization of the largest Golgi matrix protein giantin, along with impaired transport of selected hepatic proteins.
      Title: Giantin Is Required for Post-Alcohol Recovery of Golgi in Liver Cells.
    2. giantin plays a pivotal role in coordinated production of aggrecan, link protein and type XI collagen in chondrocytes.
      Title: Giantin is required for coordinated production of aggrecan, link protein and type XI collagen during chondrogenesis.
    3. concluded that mutation of the Golgb1 gene is responsible for the phenotypic characteristics including osteochondrodysplasia of ocd/ocd, and that giantin plays a pivotal role in multiple aspects of chondrogenesis
      Title: Insertional mutation in the Golgb1 gene is associated with osteochondrodysplasia and systemic edema in the OCD rat.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in chondrocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    golgin subfamily B member 1
    Names
    Golgin subfamily B member 1
    golgi autoantigen, golgin subfamily b, macrogolgin 1
    golgi-associated protein GCP360
    golgin B1, golgi integral membrane protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138885.2 → NP_620240.2  golgin subfamily B member 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6IRA0, G3V6A8, Q63714
      Related
      ENSRNOP00000003255.3, ENSRNOT00000003255.5
      Conserved Domains (3) summary
      COG1196
      Location:1298 → 2128
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK00252
      Location:45 → 114
      alaS; alanyl-tRNA synthetase; Reviewed
      TIGR02168
      Location:679 → 1582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      77348573..77406165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597867.3 → XP_017453356.1  golgin subfamily B member 1 isoform X4

      UniProtKB/TrEMBL
      A6IRA0, G3V6A8, Q63714
      Conserved Domains (3) summary
      COG1196
      Location:1298 → 2128
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK00252
      Location:45 → 114
      alaS; alanyl-tRNA synthetase; Reviewed
      TIGR02168
      Location:679 → 1582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_008768700.4 → XP_008766922.1  golgin subfamily B member 1 isoform X3

      UniProtKB/TrEMBL
      Q63714
      Conserved Domains (3) summary
      COG1196
      Location:1333 → 2163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:189 → 922
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10211
      Location:1137 → 1203
      Ax_dynein_light; Axonemal dynein light chain

    3. XM_008768699.4 → XP_008766921.1  golgin subfamily B member 1 isoform X2

      UniProtKB/TrEMBL
      Q63714
      Conserved Domains (3) summary
      COG1196
      Location:1334 → 2164
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:715 → 1618
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10211
      Location:1138 → 1204
      Ax_dynein_light; Axonemal dynein light chain

    4. XM_006248379.5 → XP_006248441.1  golgin subfamily B member 1 isoform X1

      See identical proteins and their annotated locations for XP_006248441.1

      UniProtKB/TrEMBL
      A0A8I5ZUB6
      Related
      ENSRNOP00000069873.2
      Conserved Domains (4) summary
      COG1196
      Location:1339 → 2169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK00252
      Location:45 → 114
      alaS; alanyl-tRNA synthetase; Reviewed
      PRK12704
      Location:63 → 181
      PRK12704; phosphodiesterase; Provisional
      TIGR02168
      Location:720 → 1623
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. XM_063270269.1 → XP_063126339.1  golgin subfamily B member 1 isoform X4

      UniProtKB/TrEMBL
      A6IRA0, G3V6A8

    6. XM_063270268.1 → XP_063126338.1  golgin subfamily B member 1 isoform X3

    7. XM_063270265.1 → XP_063126335.1  golgin subfamily B member 1 isoform X2

    8. XM_006248380.5 → XP_006248442.1  golgin subfamily B member 1 isoform X1

      See identical proteins and their annotated locations for XP_006248442.1

      UniProtKB/TrEMBL
      A0A8I5ZUB6
      Conserved Domains (4) summary
      COG1196
      Location:1339 → 2169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK00252
      Location:45 → 114
      alaS; alanyl-tRNA synthetase; Reviewed
      PRK12704
      Location:63 → 181
      PRK12704; phosphodiesterase; Provisional
      TIGR02168
      Location:720 → 1623
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    9. XM_063270267.1 → XP_063126337.1  golgin subfamily B member 1 isoform X3

    10. XM_063270264.1 → XP_063126334.1  golgin subfamily B member 1 isoform X1

    11. XM_063270270.1 → XP_063126340.1  golgin subfamily B member 1 isoform X5

    12. XM_008768703.4 → XP_008766925.2  golgin subfamily B member 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZUB6, Q63714
    Nucleotide Protein Strain
    Heading Accession and Version

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