PTGFR prostaglandin F receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: PTGFRprovided by HGNC
Official Full Name: prostaglandin F receptorprovided by HGNC
Primary source: HGNC:HGNC:9600
See related: Ensembl:ENSG00000122420 MIM:600563; AllianceGenome:HGNC:9600
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FP
Summary: The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in endometrium (RPKM 7.8), urinary bladder (RPKM 5.1) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p31.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (78490974..78540701)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (78329334..78379549)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (78956659..79006386)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ligand-induced activation and G protein coupling of prostaglandin F2alpha receptor.
Title: Ligand-induced activation and G protein coupling of prostaglandin F(2α) receptor.
Replicative verification of susceptibility genes previously identified from families with segregating developmental dysplasia of the hip.
Title: Replicative verification of susceptibility genes previously identified from families with segregating developmental dysplasia of the hip.
Data, including data from studies using transgenic mice, suggest that signaling via prostaglandin-F2alpha/PTGFR and Camk2g/p38/Foxo1 MAP kinase/calcium pathways are involved in regulation of hepatic gluconeogenesis in both obesity and fasting. (PTGFR = prostaglandin F2alpha receptor; Camk2g = calcium-calmodulin-dependent protein kinase type 2 gamma; p38 = p38 MAP kinase; Foxo1 = forkhead box transcription factor O1)
Title: Prostaglandin F(2α) Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity.
Data suggest that allosteric communication between heterodimeric AT1R and PTGFR is mediated through GNAQ and may also involve proximal phospholipase C but not distal protein kinase C signaling partners; PTGFR activation has negligible effects on AT1R-based conformational biosensors. (AT1R = angiotensin II receptor, type 1; PTGFR = prostaglandin F2alpha receptor; GNAQ = GTP-binding protein G[q] subunit alpha)
Title: Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors.
The genotype frequencies of six SNPs in AFAP1, GMDS and PTGFR genes were conformed to Hardy-Weinberg equilibrium (HWE).
Title: Correlations of AFAP1, GMDS and PTGFR gene polymorphisms with intra-ocular pressure response to latanoprost in patients with primary open-angle glaucoma.
these results indicated that the actions of AKR1C3 can produce FP receptor ligands whose activation results in carcinoma cell survival in breast cancer.
Title: 11β-Prostaglandin F2α, a bioactive metabolite catalyzed by AKR1C3, stimulates prostaglandin F receptor and induces slug expression in breast cancer.
The results indicated that the rs12731181 G allele of the Prostaglandin F2alpha Receptor Gene was associated with susceptibility to essential hypertension.
Title: Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F2α Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population.
Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients
Title: Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients.
The SNPs of the PTGFR and MMP-1 genes may determine the latanoprost response in a white European Spanish population.
Title: Association between SNPs of Metalloproteinases and Prostaglandin F2α Receptor Genes and Latanoprost Response in Open-Angle Glaucoma.
Angiotensin II type I and prostaglandin F2alpha receptors cooperatively modulate signaling in vascular smooth muscle cells
Title: Angiotensin II type I and prostaglandin F2α receptors cooperatively modulate signaling in vascular smooth muscle cells.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. EBI GWAS Catalog EBI GWAS CatalogPubMed
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC170950P7 (e-PCR)
- UniSTS:271625

SHGC-153836 (e-PCR)
- UniSTS:177945

SHGC-75045 (e-PCR)
- UniSTS:67869

SHGC-75020 (e-PCR)
- UniSTS:12344

SHGC-12571 (e-PCR)
- UniSTS:37717

G16225 (e-PCR)
- UniSTS:10338

D1S2876 (e-PCR), detects polymorphism
- UniSTS:68967

SHGC-150722 (e-PCR)
- UniSTS:173437

G15961 (e-PCR)
- UniSTS:22757

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables prostaglandin F receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin F receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to prostaglandin D stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in parturition	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: prostaglandin F2-alpha receptor

Names: FP prostanoid receptor; PGF receptor; PGF2 alpha receptor; prostaglandin receptor (2-alpha); prostanoid FP receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052997.1 RefSeqGene

Range

5001..54728

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000959.4 → NP_000950.1 prostaglandin F2-alpha receptor isoform a precursor

See identical proteins and their annotated locations for NP_000950.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AL136324, BC112965

Consensus CDS

CCDS686.1

UniProtKB/Swiss-Prot

A8K9Y0, P43088, Q2KHP3, Q6RYQ6, Q9P1X4

Related

ENSP00000359793.3, ENST00000370757.8

Conserved Domains (1) summary

cd15145
Location:27 → 316

7tmA_FP; prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001039585.2 → NP_001034674.1 prostaglandin F2-alpha receptor isoform b precursor

See identical proteins and their annotated locations for NP_001034674.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.

Source sequence(s)

AL136324, BC112965, CD013876

Consensus CDS

CCDS30759.1

UniProtKB/TrEMBL

F2Z2Z6

Related

ENSP00000359792.3, ENST00000370756.3

Conserved Domains (1) summary

pfam00001
Location:44 → 291

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

78490974..78540701

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047426085.1 → XP_047282041.1 prostaglandin F2-alpha receptor isoform X1

UniProtKB/Swiss-Prot

A8K9Y0, P43088, Q2KHP3, Q6RYQ6, Q9P1X4
XM_017001873.1 → XP_016857362.1 prostaglandin F2-alpha receptor isoform X2

UniProtKB/TrEMBL

F2Z2Z6
XM_047426101.1 → XP_047282057.1 prostaglandin F2-alpha receptor isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

78329334..78379549

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054337809.1 → XP_054193784.1 prostaglandin F2-alpha receptor isoform X1

UniProtKB/Swiss-Prot

A8K9Y0, P43088, Q2KHP3, Q6RYQ6, Q9P1X4
XM_054337810.1 → XP_054193785.1 prostaglandin F2-alpha receptor isoform X2