Dcaf4 DDB1 and CUL4 associated factor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dcaf4provided by MGI
Official Full Name: DDB1 and CUL4 associated factor 4provided by MGI
Primary source: MGI:MGI:1921078
See related: Ensembl:ENSMUSG00000021222 AllianceGenome:MGI:1921078
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wdr21; 1110018E21Rik
Summary: Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in adrenal medulla; alimentary system; epidermis; genitourinary system; and sensory organ. Orthologous to several human genes including DCAF4 (DDB1 and CUL4 associated factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 8.8), CNS E18 (RPKM 8.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 D1; 12 38.75 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (83567145..83588768)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (83520447..83541994)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul4-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DDB1- and CUL4-associated factor 4

Names: WD repeat domain 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001165256.1 → NP_001158728.1 DDB1- and CUL4-associated factor 4 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).

Source sequence(s)

AA763635, AC139382, BE988217, CK330131, CN722277, CX208460

Consensus CDS

CCDS88367.1

UniProtKB/TrEMBL

A0A1Y7VNZ0

Related

ENSMUSP00000152717.2, ENSMUST00000223291.2

Conserved Domains (3) summary

COG2319
Location:315 → 484

WD40; WD40 repeat [General function prediction only]

sd00039
Location:299 → 335

7WD40; WD40 repeat [structural motif]

cl02567
Location:327 → 484

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_030246.2 → NP_084522.1 DDB1- and CUL4-associated factor 4 isoform 2

See identical proteins and their annotated locations for NP_084522.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AA763635, AC139382, BB852314, BE988217, CK330131, CN722277, CX208460

Consensus CDS

CCDS26027.1

UniProtKB/TrEMBL

Q99LF7

Related

ENSMUSP00000021645.8, ENSMUST00000021645.9

Conserved Domains (2) summary

sd00039
Location:286 → 322

7WD40; WD40 repeat [structural motif]

cl29593
Location:314 → 471

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

83567145..83588768

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246953.2 → XP_030102813.1 DDB1- and CUL4-associated factor 4 isoform X3

Conserved Domains (2) summary

sd00039
Location:285 → 321

7WD40; WD40 repeat [structural motif]

cl29593
Location:313 → 470

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036157629.1 → XP_036013522.1 DDB1- and CUL4-associated factor 4 isoform X2

UniProtKB/TrEMBL

Q99LF7

Conserved Domains (2) summary

sd00039
Location:286 → 322

7WD40; WD40 repeat [structural motif]

cl29593
Location:314 → 471

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036157630.1 → XP_036013523.1 DDB1- and CUL4-associated factor 4 isoform X3

Conserved Domains (2) summary

sd00039
Location:285 → 321

7WD40; WD40 repeat [structural motif]

cl29593
Location:313 → 470

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030246954.2 → XP_030102814.1 DDB1- and CUL4-associated factor 4 isoform X4

Conserved Domains (2) summary

sd00039
Location:133 → 169

7WD40; WD40 repeat [structural motif]

cl29593
Location:161 → 318

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006516284.3 → XP_006516347.1 DDB1- and CUL4-associated factor 4 isoform X5

Conserved Domains (2) summary

sd00039
Location:71 → 107

7WD40; WD40 repeat [structural motif]

cl29593
Location:99 → 256

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030246955.2 → XP_030102815.1 DDB1- and CUL4-associated factor 4 isoform X6

Conserved Domains (2) summary

sd00039
Location:70 → 106

7WD40; WD40 repeat [structural motif]

cl29593
Location:98 → 255

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006516282.3 → XP_006516345.1 DDB1- and CUL4-associated factor 4 isoform X1

Conserved Domains (2) summary

sd00039
Location:298 → 334

7WD40; WD40 repeat [structural motif]

cl29593
Location:326 → 483

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036157631.1 → XP_036013524.1 DDB1- and CUL4-associated factor 4 isoform X5

Conserved Domains (2) summary

sd00039
Location:71 → 107

7WD40; WD40 repeat [structural motif]

cl29593
Location:99 → 256

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006516283.4 → XP_006516346.1 DDB1- and CUL4-associated factor 4 isoform X4

Conserved Domains (2) summary

sd00039
Location:133 → 169

7WD40; WD40 repeat [structural motif]

cl29593
Location:161 → 318

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...