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    Myo5c myosin VC [ Mus musculus (house mouse) ]

    Gene ID: 208943, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Myo5cprovided by MGI
    Official Full Name
    myosin VCprovided by MGI
    Primary source
    MGI:MGI:2442485
    See related
    Ensembl:ENSMUSG00000033590 AllianceGenome:MGI:2442485
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C330029I24; 9130003O20Rik
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to act upstream of or within establishment of secretory granule localization. Predicted to be located in secretory granule. Predicted to be active in actin cytoskeleton; cytoplasm; and vesicle. Is expressed in alimentary system; liver; respiratory system; and sensory organ. Orthologous to human MYO5C (myosin VC). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 9.6), lung adult (RPKM 7.2) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 D; 9 42.3 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (75139252..75212733)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75231969..75307485)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene apoptosis inhibitor 5 pseudogene Neighboring gene myosin VA Neighboring gene branched chain ketoacid dehydrogenase E1, beta polypeptide pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11749 Neighboring gene predicted gene, 33750 Neighboring gene STARR-seq mESC enhancer starr_24658 Neighboring gene predicted gene, 53503 Neighboring gene predicted gene, 19531 Neighboring gene guanine nucleotide binding protein (G protein), beta 5 Neighboring gene Bcl2-like 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Small teams of myosin Vc motors coordinate their stepping for efficient cargo transport on actin bundles. Krementsova EB, et al. J Biol Chem, 2017 Jun 30. PMID 28476885, Free PMC Article
    2. Myosin Vc is a molecular motor that functions in secretory granule trafficking. Jacobs DT, et al. Mol Biol Cell, 2009 Nov. PMID 19741097, Free PMC Article
    3. The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers. Harten SK, et al. BMC Biol, 2015 Mar 26. PMID 25857663, Free PMC Article
    4. Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function. Fang Q, et al. Sci Rep, 2019 Mar 4. PMID 30833597, Free PMC Article
    5. Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models. Soulez M, et al. Mol Cell Biol, 2019 Mar 15. PMID 30642949, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study provides a molecular basis to explain how teams of myoVc motors are suited to transport cargos such as zymogen granules on actin bundles.
      Title: Small teams of myosin Vc motors coordinate their stepping for efficient cargo transport on actin bundles.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within establishment of secretory granule localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle transport along actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    unconventional myosin-Vc

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081322.1 → NP_001074791.1  unconventional myosin-Vc

      Status: PROVISIONAL

      Source sequence(s)
      AC133947
      Consensus CDS
      CCDS40691.1
      UniProtKB/TrEMBL
      E9Q1F5
      Related
      ENSMUSP00000042229.7, ENSMUST00000036555.8
      Conserved Domains (9) summary
      smart00015
      Location:830 → 851
      IQ; Calmodulin-binding motif
      smart00242
      Location:62 → 752
      MYSc; Myosin. Large ATPases
      COG1340
      Location:890 → 1150
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd15476
      Location:1369 → 1736
      Myo5c_CBD; Cargo binding domain of myosin 5C
      cd01380
      Location:81 → 741
      MYSc_Myo5; class V myosin, motor domain
      pfam02736
      Location:12 → 48
      Myosin_N; Myosin N-terminal SH3-like domain
      cd16269
      Location:1001 → 1010
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:961 → 1030
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:952 → 1096
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      75139252..75212733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510939.4 → XP_006511002.1  unconventional myosin-Vc isoform X2

      Conserved Domains (3) summary
      COG1196
      Location:848 → 1155
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01380
      Location:81 → 741
      MYSc_Myo5; class V myosin, motor domain
      pfam00612
      Location:831 → 851
      IQ; IQ calmodulin-binding motif

    2. XM_006510940.5 → XP_006511003.1  unconventional myosin-Vc isoform X3

      Conserved Domains (3) summary
      TIGR02169
      Location:922 → 1230
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cd01380
      Location:81 → 741
      MYSc_Myo5; class V myosin, motor domain
      pfam12128
      Location:767 → 1043
      DUF3584; Protein of unknown function (DUF3584)

    3. XM_036154772.1 → XP_036010665.1  unconventional myosin-Vc isoform X4

      UniProtKB/TrEMBL
      Q8BWY8
      Conserved Domains (2) summary
      cd01380
      Location:81 → 741
      MYSc_Myo5; class V myosin, motor domain
      pfam00612
      Location:831 → 851
      IQ; IQ calmodulin-binding motif

    4. XM_006510936.5 → XP_006510999.1  unconventional myosin-Vc isoform X1

      See identical proteins and their annotated locations for XP_006510999.1

      Conserved Domains (5) summary
      cd15476
      Location:1376 → 1743
      Myo5c_CBD; Cargo binding domain of myosin 5C
      TIGR02169
      Location:922 → 1276
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cd01380
      Location:81 → 741
      MYSc_Myo5; class V myosin, motor domain
      pfam00769
      Location:1220 → 1354
      ERM; Ezrin/radixin/moesin family
      pfam12128
      Location:767 → 1043
      DUF3584; Protein of unknown function (DUF3584)

    5. XM_011242693.4 → XP_011240995.1  unconventional myosin-Vc isoform X1

      See identical proteins and their annotated locations for XP_011240995.1

      Conserved Domains (5) summary
      cd15476
      Location:1376 → 1743
      Myo5c_CBD; Cargo binding domain of myosin 5C
      TIGR02169
      Location:922 → 1276
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cd01380
      Location:81 → 741
      MYSc_Myo5; class V myosin, motor domain
      pfam00769
      Location:1220 → 1354
      ERM; Ezrin/radixin/moesin family
      pfam12128
      Location:767 → 1043
      DUF3584; Protein of unknown function (DUF3584)

    6. XM_006510935.5 → XP_006510998.1  unconventional myosin-Vc isoform X1

      See identical proteins and their annotated locations for XP_006510998.1

      Conserved Domains (5) summary
      cd15476
      Location:1376 → 1743
      Myo5c_CBD; Cargo binding domain of myosin 5C
      TIGR02169
      Location:922 → 1276
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cd01380
      Location:81 → 741
      MYSc_Myo5; class V myosin, motor domain
      pfam00769
      Location:1220 → 1354
      ERM; Ezrin/radixin/moesin family
      pfam12128
      Location:767 → 1043
      DUF3584; Protein of unknown function (DUF3584)

    RNA

    1. XR_001778835.3 RNA Sequence

    2. XR_004935364.1 RNA Sequence

    3. XR_379407.5 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145366.1: Suppressed sequence

      Description
      NM_145366.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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