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    H2-Q2 histocompatibility 2, Q region locus 2 [ Mus musculus (house mouse) ]

    Gene ID: 15013, updated on 11-Apr-2024

    Summary

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    Official Symbol
    H2-Q2provided by MGI
    Official Full Name
    histocompatibility 2, Q region locus 2provided by MGI
    Primary source
    MGI:MGI:95931
    See related
    Ensembl:ENSMUSG00000091705 AllianceGenome:MGI:95931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H-2Q2; H2-D1; H2-K1; gs14-2; Gm11132
    Summary
    Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Acts upstream of or within female pregnancy. Predicted to be located in several cellular components, including bounding membrane of organelle; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in brain; small intestine; and thymus. Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in small intestine adult (RPKM 179.7), duodenum adult (RPKM 165.2) and 3 other tissues See more
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    Genomic context

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    Location:
    17 B1; 17 18.64 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35561283..35565740)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35342307..35346764)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, Q region locus 1 Neighboring gene Nhp2 non-histone chromosome protein 2-like 1 pseudogene Neighboring gene predicted gene, 52319 Neighboring gene histocompatibility 2, Q region locus 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Embryonal carcinoma cells express Qa and Tla class I genes of the major histocompatibility complex. Ostrand-Rosenberg S, et al. Proc Natl Acad Sci U S A, 1989 Jul. PMID 2740345, Free PMC Article
    2. Identification of a recombinogenic major histocompatibility complex Q gene with diverse alleles. Cullen MK, et al. J Exp Med, 1993 Jun 1. PMID 8496692, Free PMC Article
    3. Preferential survival of mice expressing the Qa-2 antigen. Warner CM, et al. J Reprod Fertil, 1993 Sep. PMID 8283431
    4. DNA sequences of mouse H-2 and Qa genes. Kuhner MK, et al. Immunogenetics, 1989. PMID 2592022
    5. Three spontaneous H-2Db mutants are generated by genetic micro-recombination (gene conversion) events. Impact on the H-2-restricted immune responsiveness. Hemmi S, et al. J Exp Med, 1988 Dec 1. PMID 3199070, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables CD8 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MHC class I protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables T cell receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TAP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TAP complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TAP1 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TAP2 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-2-microglobulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables natural killer cell lectin-like receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide antigen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi medial cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MHC class I peptide loading complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MHC class I protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MHC class Ib protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histocompatibility 2, Q region locus 2
    Names
    MHC class II antigen D
    MHC class II antigen K
    MHC classIb like protein GS14-2
    class Ib major histocompatibility complex

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368740.1 → NP_001355669.1  histocompatibility 2, Q region locus 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      CR974466
      UniProtKB/TrEMBL
      Q2XN57
      Conserved Domains (2) summary
      cd07698
      Location:204 → 296
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:23 → 200
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    2. NM_010392.3 → NP_034522.2  histocompatibility 2, Q region locus 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034522.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CR974466
      Consensus CDS
      CCDS28696.1
      UniProtKB/TrEMBL
      Q2XN57, Q4KN81
      Related
      ENSMUSP00000078138.6, ENSMUST00000074806.12
      Conserved Domains (3) summary
      cd07698
      Location:204 → 296
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:22 → 200
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      pfam06623
      Location:334 → 357
      MHC_I_C; MHC_I C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35561283..35565740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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