Kif20b kinesin family member 20B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif20bprovided by MGI
Official Full Name: kinesin family member 20Bprovided by MGI
Primary source: MGI:MGI:2444576
See related: Ensembl:ENSMUSG00000024795 AllianceGenome:MGI:2444576
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MPP1; 33cex; magoo; Mphosph1; C330014J10Rik
Summary: Predicted to enable several functions, including ATP hydrolysis activity; WW domain binding activity; and plus-end-directed microtubule motor activity. Involved in several processes, including positive regulation of mitotic cytokinetic process; positive regulation of neuron migration; and protein localization to microtubule. Acts upstream of or within neural tube closure; regulation of establishment of protein localization; and regulation of neuron migration. Located in several cellular components, including midbody; perinuclear region of cytoplasm; and spindle midzone. Is expressed in cerebral cortex marginal layer; cerebral cortex ventricular layer; cortical plate; and cortical subplate. Used to study microcephaly. Orthologous to human KIF20B (kinesin family member 20B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E11.5 (RPKM 8.8), liver E14 (RPKM 6.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C1; 19 29.79 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (34899735..34953150)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (34922335..34975750)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study investigated whether polarized furrowing and abscission in mouse neural stem cells are regulated differently at earlier and later stages and in a cytokinesis mutant, Kif20b.
Title: Cytokinesis and postabscission midbody remnants are regulated during mammalian brain development.
These results demonstrate that Kif20b is required cell-autonomously for proper morphogenesis of cortical pyramidal neurons. Kif20b regulates neuron polarization, and axon and dendrite branching, outgrowth, and caliber.
Title: Mutation of Kinesin-6 Kif20b causes defects in cortical neuron polarization and morphogenesis.
Kif20b is required for proper midbody organization and abscission in polarized cortical stem cells and has a crucial role in the regulation of cerebral cortex growth.
Title: The vertebrate-specific Kinesin-6, Kif20b, is required for normal cytokinesis of polarized cortical stem cells and cerebral cortex size.
our data demonstrate the importance of the Shootin1/KIF20B interaction to the dynamic process of pyramidal neuronal polarization and migration.
Title: Shootin1 acts in concert with KIF20B to promote polarization of migrating neurons.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (3) 1 citation
Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables WW domain binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cytokinetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of establishment of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of establishment of protein localization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of neuron migration	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in contractile ring	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle midzone	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kinesin-like protein KIF20B

Names: M-phase phosphoprotein 1; N-6 kinesin; kinesin-related motor interacting with PIN1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362434.1 → NP_001349363.1 kinesin-like protein KIF20B isoform 2

Status: VALIDATED

Source sequence(s)

AC113244, BC172148

Consensus CDS

CCDS89382.1

UniProtKB/TrEMBL

B7ZWN1

Related

ENSMUSP00000153034.2, ENSMUST00000223907.2

Conserved Domains (3) summary

cd01368
Location:58 → 475

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

cl25574
Location:1415 → 1701

TOP2c; TopoisomeraseII

cl25732
Location:527 → 1323

SMC_N; RecF/RecN/SMC N terminal domain
NM_183046.2 → NP_898867.1 kinesin-like protein KIF20B isoform 1

See identical proteins and their annotated locations for NP_898867.1

Status: VALIDATED

Source sequence(s)

AC113244, AK045067, AK135856, AK143629, AK145779, AY259532

Consensus CDS

CCDS37967.1

UniProtKB/Swiss-Prot

E9QPW5, Q3V347, Q80VC0, Q80WE4, Q8BLI2, Q99PT5

Related

ENSMUSP00000084599.6, ENSMUST00000087341.7

Conserved Domains (3) summary

COG1196
Location:627 → 1492

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PTZ00108
Location:1455 → 1741

PTZ00108; DNA topoisomerase 2-like protein; Provisional

cd01368
Location:58 → 475

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

34899735..34953150

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527082.4 → XP_006527145.1 kinesin-like protein KIF20B isoform X2

Conserved Domains (3) summary

COG1196
Location:627 → 1492

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PTZ00108
Location:1455 → 1707

PTZ00108; DNA topoisomerase 2-like protein; Provisional

cd01368
Location:58 → 475

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
XM_036161594.1 → XP_036017487.1 kinesin-like protein KIF20B isoform X3

Conserved Domains (4) summary

PTZ00121
Location:1085 → 1512

PTZ00121; MAEBL; Provisional

PTZ00108
Location:1415 → 1667

PTZ00108; DNA topoisomerase 2-like protein; Provisional

TIGR02168
Location:527 → 1291

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01368
Location:58 → 475

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
XM_006527081.4 → XP_006527144.1 kinesin-like protein KIF20B isoform X1

See identical proteins and their annotated locations for XP_006527144.1

UniProtKB/Swiss-Prot

E9QPW5, Q3V347, Q80VC0, Q80WE4, Q8BLI2, Q99PT5

Conserved Domains (3) summary

COG1196
Location:627 → 1492

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PTZ00108
Location:1455 → 1741

PTZ00108; DNA topoisomerase 2-like protein; Provisional

cd01368
Location:58 → 475

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
XM_030250939.2 → XP_030106799.1 kinesin-like protein KIF20B isoform X5

Conserved Domains (3) summary

PTZ00108
Location:1029 → 1315

PTZ00108; DNA topoisomerase 2-like protein; Provisional

TIGR02168
Location:141 → 937

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl22853
Location:1 → 89

Motor_domain; Myosin and Kinesin motor domain
XM_006527084.5 → XP_006527147.1 kinesin-like protein KIF20B isoform X4

See identical proteins and their annotated locations for XP_006527147.1

Conserved Domains (4) summary

COG5059
Location:2 → 257

KIP1; Kinesin-like protein [Cytoskeleton]

PTZ00108
Location:1069 → 1355

PTZ00108; DNA topoisomerase 2-like protein; Provisional

TIGR02168
Location:287 → 977

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl22853
Location:1 → 89

Motor_domain; Myosin and Kinesin motor domain
XM_006527080.3 → XP_006527143.1 kinesin-like protein KIF20B isoform X1

See identical proteins and their annotated locations for XP_006527143.1

UniProtKB/Swiss-Prot

E9QPW5, Q3V347, Q80VC0, Q80WE4, Q8BLI2, Q99PT5

Conserved Domains (3) summary

COG1196
Location:627 → 1492

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PTZ00108
Location:1455 → 1741

PTZ00108; DNA topoisomerase 2-like protein; Provisional

cd01368
Location:58 → 475

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup