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    Fat2 FAT atypical cadherin 2 [ Mus musculus (house mouse) ]

    Gene ID: 245827, updated on 12-May-2024

    Summary

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    Official Symbol
    Fat2provided by MGI
    Official Full Name
    FAT atypical cadherin 2provided by MGI
    Primary source
    MGI:MGI:2685369
    See related
    Ensembl:ENSMUSG00000055333 AllianceGenome:MGI:2685369
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EMI2; Fath2; Gm523; mKIAA0811
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in cell-substrate adhesion; epithelial cell migration; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to act upstream of or within cell adhesion. Predicted to be located in Golgi apparatus; cell junction; and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in adherens junction. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; nose; and urinary system. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 45. Orthologous to human FAT2 (FAT atypical cadherin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 20.8) and bladder adult (RPKM 3.4) See more
    Orthologs
    human all
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    Genomic context

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    See Fat2 in Genome Data Viewer
    Location:
    11 B1.3; 11 32.5 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (55141435..55228331, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (55250609..55337505, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 1, opposite strand Neighboring gene STARR-positive B cell enhancer mm9_chr11:55017598-55017899 Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 1 Neighboring gene STARR-seq mESC enhancer starr_29532 Neighboring gene STARR-seq mESC enhancer starr_29533 Neighboring gene predicted gene, 31842 Neighboring gene STARR-seq mESC enhancer starr_29535 Neighboring gene STARR-seq mESC enhancer starr_29537 Neighboring gene secreted acidic cysteine rich glycoprotein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Possible involvement of mitogen- and stress-activated protein kinase 1, MSK1, in metaphase-II arrest through phosphorylation of EMI2 in mouse oocytes. Miyagaki Y, et al. Dev Biol, 2011 Nov 1. PMID 21924255
    2. Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila. Rock R, et al. Dev Dyn, 2005 Nov. PMID 16059920
    3. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Barlow JL, et al. Nat Med, 2010 Jan. PMID 19966810, Free PMC Article
    4. Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development. Lodge EJ, et al. JCI Insight, 2020 Oct 27. PMID 33108146, Free PMC Article
    5. ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination. Capecchi MR, et al. Nat Commun, 2015 Nov 19. PMID 26581405, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protocadherin Fat 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029988.2 → NP_001025159.1  protocadherin Fat 2 precursor

      See identical proteins and their annotated locations for NP_001025159.1

      Status: PROVISIONAL

      Source sequence(s)
      AK132523, AK173031, AL713870
      Consensus CDS
      CCDS36157.1
      UniProtKB/Swiss-Prot
      Q3V1D4, Q5F226, Q69ZY7
      Related
      ENSMUSP00000104492.2, ENSMUST00000108864.2
      Conserved Domains (5) summary
      cd11304
      Location:3328 → 3424
      Cadherin_repeat; Cadherin tandem repeat domain
      cd00054
      Location:3953 → 3986
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:3992 → 4022
      EGF; EGF-like domain
      cl29226
      Location:1883 → 1959
      Cadherin; Cadherin domain
      pfam02210
      Location:3802 → 3920
      Laminin_G_2; Laminin G domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      55141435..55228331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533322.4 → XP_006533385.1  protocadherin Fat 2 isoform X1

      See identical proteins and their annotated locations for XP_006533385.1

      UniProtKB/Swiss-Prot
      Q3V1D4, Q5F226, Q69ZY7
      Conserved Domains (5) summary
      cd11304
      Location:3328 → 3424
      Cadherin_repeat; Cadherin tandem repeat domain
      cd00054
      Location:3953 → 3986
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:3992 → 4022
      EGF; EGF-like domain
      cl29226
      Location:1883 → 1959
      Cadherin; Cadherin domain
      pfam02210
      Location:3802 → 3920
      Laminin_G_2; Laminin G domain

    2. XM_030246003.1 → XP_030101863.1  protocadherin Fat 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3V1D4, Q5F226, Q69ZY7
      Related
      ENSMUSP00000067556.7, ENSMUST00000068853.13
      Conserved Domains (5) summary
      cd11304
      Location:3328 → 3424
      Cadherin_repeat; Cadherin tandem repeat domain
      cd00054
      Location:3953 → 3986
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:3992 → 4022
      EGF; EGF-like domain
      cl29226
      Location:1883 → 1959
      Cadherin; Cadherin domain
      pfam02210
      Location:3802 → 3920
      Laminin_G_2; Laminin G domain

    3. XM_006533323.4 → XP_006533386.1  protocadherin Fat 2 isoform X1

      See identical proteins and their annotated locations for XP_006533386.1

      UniProtKB/Swiss-Prot
      Q3V1D4, Q5F226, Q69ZY7
      Conserved Domains (5) summary
      cd11304
      Location:3328 → 3424
      Cadherin_repeat; Cadherin tandem repeat domain
      cd00054
      Location:3953 → 3986
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:3992 → 4022
      EGF; EGF-like domain
      cl29226
      Location:1883 → 1959
      Cadherin; Cadherin domain
      pfam02210
      Location:3802 → 3920
      Laminin_G_2; Laminin G domain

    RNA

    1. XR_004936961.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5F226.1 GenPept UniProtKB/Swiss-Prot:Q5F226

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