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    mtmr4 myotubularin related protein 4 [ Danio rerio (zebrafish) ]

    Gene ID: 393584, updated on 11-Apr-2024

    Summary

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    Official Symbol
    mtmr4provided by ZNC
    Official Full Name
    myotubularin related protein 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1208
    See related
    AllianceGenome:ZFIN:ZDB-GENE-040426-1208
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63645
    Summary
    Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to act upstream of or within protein dephosphorylation and transforming growth factor beta receptor signaling pathway. Orthologous to human MTMR4 (myotubularin related protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See mtmr4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (2301323..2810344, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (2033113..2540122, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene glucuronidase, beta Neighboring gene carbonic anhydrase IV a Neighboring gene uncharacterized LOC103910293 Neighboring gene citron rho-interacting serine/threonine kinase a Neighboring gene RAB35, member RAS oncogene family a Neighboring gene uncharacterized LOC101884896 Neighboring gene Rab9 effector protein with kelch motifs Neighboring gene DDRGK domain-containing protein 1 Neighboring gene guanine nucleotide binding protein (G protein), gamma 10 Neighboring gene leucine zipper putative tumor suppressor 3 Neighboring gene FAST kinase domains 5 Neighboring gene heat shock protein 5 Neighboring gene 4-hydroxyphenylpyruvate dioxygenase a Neighboring gene ring finger protein 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63645

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myotubularin-related protein 4
    Names
    myotubularin-related protein 4-like
    XP_002667032.4
    XP_009299405.1
    XP_021332402.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      2301323..2810344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301130.3 → XP_009299405.1  myotubularin-related protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A8M3ARV3
      Conserved Domains (3) summary
      cd15733
      Location:1011 → 1070
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      pfam06602
      Location:160 → 513
      Myotub-related; Myotubularin-like phosphatase domain
      cl17171
      Location:23 → 136
      PH-like; Pleckstrin homology-like domain

    2. XM_002666986.6 → XP_002667032.4  myotubularin-related protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M1RI73
      Conserved Domains (3) summary
      cd15733
      Location:1023 → 1082
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      pfam06602
      Location:172 → 525
      Myotub-related; Myotubularin-like phosphatase domain
      cl17171
      Location:35 → 148
      PH-like; Pleckstrin homology-like domain

    3. XM_021476727.1 → XP_021332402.1  myotubularin-related protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PLQ5
      Conserved Domains (3) summary
      cd15733
      Location:951 → 1010
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      pfam06602
      Location:99 → 455
      Myotub-related; Myotubularin-like phosphatase domain
      cl17171
      Location:6 → 76
      PH-like; Pleckstrin homology-like domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_200612.1: Suppressed sequence

      Description
      NM_200612.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version

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