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    actn3b actinin alpha 3b [ Danio rerio (zebrafish) ]

    Gene ID: 323320, updated on 25-Apr-2024

    Summary

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    Official Symbol
    actn3bprovided by ZNC
    Official Full Name
    actinin alpha 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2040
    See related
    Ensembl:ENSDARG00000001431 AllianceGenome:ZFIN:ZDB-GENE-030131-2040
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb95c03; zgc:77243; wu:fb95c03; wu:fc11d03
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization and muscle cell development. Predicted to be active in several cellular components, including Z disc; cell junction; and cortical actin cytoskeleton. Is expressed in several structures, including musculature system; ovary; pharyngeal arch 3-7; post-vent region; and segmental plate. Orthologous to human ACTN3 (actinin alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See actn3b in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (6969733..7131865)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (6814866..6898486)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene copper chaperone for superoxide dismutase-like Neighboring gene protein kinase D4 Neighboring gene serine/threonine-protein kinase D1-like Neighboring gene RNA binding motif protein 14b Neighboring gene copper chaperone for superoxide dismutase Neighboring gene galactose-3-O-sulfotransferase 3 Neighboring gene Ras and Rab interactor 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Tie1 regulates zebrafish cardiac morphogenesis through Tolloid-like 1 expression. Carlantoni C, et al. Dev Biol, 2021 Jan 1. PMID 32971120
    2. Multiple influences of blood flow on cardiomyocyte hypertrophy in the embryonic zebrafish heart. Lin YF, et al. Dev Biol, 2012 Feb 15. PMID 22192888, Free PMC Article
    3. Explant culture of adult zebrafish hearts for epicardial regeneration studies. Cao J, et al. Nat Protoc, 2016 May. PMID 27055096, Free PMC Article
    4. The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Wang J, et al. Development, 2011 Aug. PMID 21752928, Free PMC Article
    5. In vivo analysis of cardiomyocyte proliferation during trabeculation. Uribe V, et al. Development, 2018 Jul 30. PMID 30061167

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    actinin alpha 3b; alpha-actinin-3b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205544.2 → NP_991107.2  alpha-actinin-3b

      Status: VALIDATED

      Source sequence(s)
      AL808019
      UniProtKB/TrEMBL
      D1GJ57, F6NIM1, Q8AX99
      Related
      ENSDARP00000000803.9, ENSDART00000001649.10
      Conserved Domains (5) summary
      COG5069
      Location:40 → 404
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:406 → 633
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:641 → 744
      Spectrin; Spectrin repeat
      pfam08726
      Location:828 → 894
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cl25352
      Location:754 → 864
      EFh_PEF; The penta-EF hand (PEF) family

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      6969733..7131865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021477400.1 → XP_021333075.1  actinin alpha 3b isoform X1

      UniProtKB/TrEMBL
      D1GJ57, F6NIM1, Q8AX99
      Related
      ENSDARP00000145426.1, ENSDART00000189886.1
      Conserved Domains (5) summary
      COG5069
      Location:40 → 404
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:406 → 633
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:641 → 744
      Spectrin; Spectrin repeat
      pfam08726
      Location:828 → 894
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cl25352
      Location:754 → 864
      EFh_PEF; The penta-EF hand (PEF) family
    Nucleotide Protein Strain
    Heading Accession and Version

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