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    FGFR4 fibroblast growth factor receptor 4 [ Canis lupus familiaris (dog) ]

    Gene ID: 489095, updated on 5-Mar-2024

    Summary

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    Official Symbol
    FGFR4provided by VGNC
    Official Full Name
    fibroblast growth factor receptor 4provided by VGNC
    Primary source
    VGNC:VGNC:40861
    See related
    Ensembl:ENSCAFG00845010987
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (36607886..36618835, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (36209722..36220671, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (37130265..37141210, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (36434871..36445815, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (36622022..36632969, complement)

    Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor binding SET domain protein 1 Neighboring gene coiled-coil-helix-coiled-coil-helix domain-containing protein 2-like Neighboring gene uncharacterized LOC111095710 Neighboring gene normal mucosa of esophagus-specific gene 1 protein Neighboring gene zinc finger protein 346 Neighboring gene uncharacterized LOC102152356

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fibroblast growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of bile acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibroblast growth factor receptor 4
    XP_005619227.1
    XP_005619228.1
    XP_005619229.1
    XP_013968466.1
    XP_038329520.1
    XP_038329521.1
    XP_038329522.1
    XP_038329523.1
    XP_038329524.1
    XP_038390593.1
    XP_038390594.1
    XP_038390595.1
    XP_038390596.1
    XP_038390597.1
    XP_038454897.1
    XP_038454898.1
    XP_038454899.1
    XP_038454900.1
    XP_038454901.1
    XP_038519201.1
    XP_038519202.1
    XP_038519203.1
    XP_038519204.1
    XP_038519205.1
    XP_546211.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051808.1 Reference ROS_Cfam_1.0

      Range
      36607886..36618835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038663276.1 → XP_038519204.1  fibroblast growth factor receptor 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KG87, A0A8I3NCC1, A0A8P0NHY7
      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    2. XM_038663277.1 → XP_038519205.1  fibroblast growth factor receptor 4 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KG87, A0A8C0M6P0
      Conserved Domains (4) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:205 → 209
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:200 → 300
      Ig; Immunoglobulin domain
      cl21453
      Location:403 → 714
      PKc_like; Protein Kinases, catalytic domain

    3. XM_038663273.1 → XP_038519201.1  fibroblast growth factor receptor 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KG87, A0A8I3NCC1, A0A8P0NHY7
      Related
      ENSCAFP00845015179.1, ENSCAFT00845019413.1
      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    4. XM_038663275.1 → XP_038519203.1  fibroblast growth factor receptor 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KG87, A0A8I3NCC1, A0A8P0NHY7
      Related
      ENSCAFP00845015548.1, ENSCAFT00845019854.1
      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    5. XM_038663274.1 → XP_038519202.1  fibroblast growth factor receptor 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KG87, A0A8I3NCC1, A0A8P0NHY7
      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049264.1 Alternate UMICH_Zoey_3.1

      Range
      36434871..36445815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038473595.1 → XP_038329523.1  fibroblast growth factor receptor 4 isoform X1

      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    2. XM_038473596.1 → XP_038329524.1  fibroblast growth factor receptor 4 isoform X2

      Conserved Domains (4) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:205 → 209
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:200 → 300
      Ig; Immunoglobulin domain
      cl21453
      Location:403 → 714
      PKc_like; Protein Kinases, catalytic domain

    3. XM_038473592.1 → XP_038329520.1  fibroblast growth factor receptor 4 isoform X1

      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    4. XM_038473594.1 → XP_038329522.1  fibroblast growth factor receptor 4 isoform X1

      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    5. XM_038473593.1 → XP_038329521.1  fibroblast growth factor receptor 4 isoform X1

      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

      Range
      36622022..36632969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038598972.1 → XP_038454900.1  fibroblast growth factor receptor 4 isoform X1

      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    2. XM_038598973.1 → XP_038454901.1  fibroblast growth factor receptor 4 isoform X2

      Conserved Domains (4) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:205 → 209
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:200 → 300
      Ig; Immunoglobulin domain
      cl21453
      Location:403 → 714
      PKc_like; Protein Kinases, catalytic domain

    3. XM_038598969.1 → XP_038454897.1  fibroblast growth factor receptor 4 isoform X1

      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    4. XM_038598971.1 → XP_038454899.1  fibroblast growth factor receptor 4 isoform X1

      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    5. XM_038598970.1 → XP_038454898.1  fibroblast growth factor receptor 4 isoform X1

      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

      Range
      37130265..37141210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038534668.1 → XP_038390596.1  fibroblast growth factor receptor 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KG87, A0A8I3NCC1, A0A8P0NHY7
      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    2. XM_038534669.1 → XP_038390597.1  fibroblast growth factor receptor 4 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KG87, A0A8C0M6P0
      Conserved Domains (4) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:205 → 209
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:200 → 300
      Ig; Immunoglobulin domain
      cl21453
      Location:403 → 714
      PKc_like; Protein Kinases, catalytic domain

    3. XM_038534665.1 → XP_038390593.1  fibroblast growth factor receptor 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KG87, A0A8I3NCC1, A0A8P0NHY7
      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    4. XM_038534667.1 → XP_038390595.1  fibroblast growth factor receptor 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KG87, A0A8I3NCC1, A0A8P0NHY7
      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    5. XM_038534666.1 → XP_038390594.1  fibroblast growth factor receptor 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KG87, A0A8I3NCC1, A0A8P0NHY7
      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      36209722..36220671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_546211.6 → XP_546211.3  fibroblast growth factor receptor 4 isoform X1

      See identical proteins and their annotated locations for XP_546211.3

      UniProtKB/TrEMBL
      A0A8C0KG87, A0A8I3NCC1, A0A8P0NHY7
      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    2. XM_014112991.3 → XP_013968466.1  fibroblast growth factor receptor 4 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KG87, A0A8C0M6P0
      Conserved Domains (4) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:205 → 209
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:200 → 300
      Ig; Immunoglobulin domain
      cl21453
      Location:403 → 714
      PKc_like; Protein Kinases, catalytic domain

    3. XM_005619170.3 → XP_005619227.1  fibroblast growth factor receptor 4 isoform X1

      See identical proteins and their annotated locations for XP_005619227.1

      UniProtKB/TrEMBL
      A0A8C0KG87, A0A8I3NCC1, A0A8P0NHY7
      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    4. XM_005619172.4 → XP_005619229.1  fibroblast growth factor receptor 4 isoform X1

      See identical proteins and their annotated locations for XP_005619229.1

      UniProtKB/TrEMBL
      A0A8C0KG87, A0A8I3NCC1, A0A8P0NHY7
      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain

    5. XM_005619171.4 → XP_005619228.1  fibroblast growth factor receptor 4 isoform X1

      See identical proteins and their annotated locations for XP_005619228.1

      UniProtKB/TrEMBL
      A0A8C0KG87, A0A8I3NCC1, A0A8P0NHY7
      Conserved Domains (5) summary
      smart00408
      Location:50 → 107
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:249 → 252
      Ig; Ig strand A [structural motif]
      cd05857
      Location:147 → 241
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:249 → 351
      Ig; Immunoglobulin domain
      cl21453
      Location:454 → 765
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
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