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    pafah1b1a platelet-activating factor acetylhydrolase 1b, regulatory subunit 1a [ Danio rerio (zebrafish) ]

    Gene ID: 394246, updated on 19-Jun-2024

    Summary

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    Official Symbol
    pafah1b1aprovided by ZNC
    Official Full Name
    platelet-activating factor acetylhydrolase 1b, regulatory subunit 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040116-2
    See related
    Ensembl:ENSDARG00000032013 AllianceGenome:ZFIN:ZDB-GENE-040116-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable dynein complex binding activity; microtubule plus-end binding activity; and protein heterodimerization activity. Acts upstream of or within brain morphogenesis. Located in cytoplasm. Is expressed in several structures, including gill; heart; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in lissencephaly and lissencephaly 1. Orthologous to human PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See pafah1b1a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (25269923..25319586, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (25336935..25384321, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene MAX network transcriptional repressor a Neighboring gene methyltransferase 16, N6-methyladenosine Neighboring gene clustered mitochondria (cluA/CLU1) homolog a Neighboring gene coiled-coil domain containing 92Ba

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of the overlapping expression patterns of the zebrafish LIS1 orthologs. Drerup CM, et al. Gene Expr Patterns, 2010 Jan. PMID 19822223
    2. Expression and function on embryonic development of lissencephaly-1 genes in zebrafish. Sun C, et al. Acta Biochim Biophys Sin (Shanghai), 2009 Aug. PMID 19657569
    3. Mechanism of positioning the cell nucleus in vertebrate photoreceptors. Tsujikawa M, et al. Proc Natl Acad Sci U S A, 2007 Sep 11. PMID 17785424, Free PMC Article
    4. Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities. Bercier V, et al. Mol Neurodegener, 2019 Jul 10. PMID 31291987, Free PMC Article
    5. Phenotypic analysis of catastrophic childhood epilepsy genes. Griffin A, et al. Commun Biol, 2021 Jun 3. PMID 34083748, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables dynein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within brain morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within brain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule organizing center organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule sliding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reelin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retrograde axonal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of microtubule associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lissencephaly-1 homolog A
    Names
    lis1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201345.1 → NP_958502.1  lissencephaly-1 homolog A

      See identical proteins and their annotated locations for NP_958502.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053205
      UniProtKB/Swiss-Prot
      Q07DR1, Q7T394
      UniProtKB/TrEMBL
      B2GQS8
      Related
      ENSDARP00000042217.5, ENSDART00000042218.6
      Conserved Domains (4) summary
      COG2319
      Location:100 → 410
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08513
      Location:9 → 35
      LisH; LisH
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      25269923..25319586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157575.4 → XP_005157632.1  lissencephaly-1 homolog A isoform X1

      See identical proteins and their annotated locations for XP_005157632.1

      UniProtKB/Swiss-Prot
      Q07DR1, Q7T394
      UniProtKB/TrEMBL
      B2GQS8
      Conserved Domains (4) summary
      COG2319
      Location:100 → 410
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08513
      Location:9 → 35
      LisH; LisH
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7T394.3 GenPept UniProtKB/Swiss-Prot:Q7T394

    Gene LinkOut

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