Mprip myosin phosphatase Rho interacting protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mpripprovided by RGD
Official Full Name: myosin phosphatase Rho interacting proteinprovided by RGD
Primary source: RGD:619947
See related: Ensembl:ENSRNOG00000003226 AllianceGenome:RGD:619947
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mrip; M-rip; Rhoip3; p116Rip
Summary: Predicted to enable actin filament binding activity. Involved in maintenance of protein location in cell; negative regulation of myosin-light-chain-phosphatase activity; and positive regulation of protein phosphorylation. Located in stress fiber. Orthologous to human MPRIP (myosin phosphatase Rho interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 366.3), Brain (RPKM 254.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (44953472..45073388)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (44453949..44573843)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (46018397..46133580)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells necroptosis.
Title: Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells necroptosis.
RIP3 Inhibition ameliorates chronic constriction injury-induced neuropathic pain by suppressing JNK signaling.
Title: RIP3 Inhibition ameliorates chronic constriction injury-induced neuropathic pain by suppressing JNK signaling.
The results indicated that RIP3 is expressed differentially in retinal neurons in adult rats, including subsets of ganglion cells, amacrine and horizontal cells. RIP3 protein levels are elevated rapidly following aHIOP
Title: Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response.
decreased insulin-stimulated MRIP/MYPT1 association may contribute to the impaired insulin-mediated vasodilation observed in the diabetic vasculature
Title: Impaired insulin-stimulated myosin phosphatase Rho-interacting protein signaling in diabetic Goto-Kakizaki vascular smooth muscle cells.
myosin phosphatase-rho interacting protein is a scaffold linking RhoA to regulate myosin phosphatase at the stress fiber.
Title: Targeting by myosin phosphatase-RhoA interacting protein mediates RhoA/ROCK regulation of myosin phosphatase.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA874795 (e-PCR)
- UniSTS:261221

BE111005 (e-PCR)
- UniSTS:245608

BF404236 (e-PCR)
- UniSTS:246974

AA859242 (e-PCR)
- UniSTS:243915

BF411669 (e-PCR)
- UniSTS:247779

d01504sbk (e-PCR)
- UniSTS:96244

RH137811 (e-PCR)
- UniSTS:219898

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in maintenance of protein location in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myosin phosphatase Rho-interacting protein

Names: RIP3; Rho interacting protein 3; rho-interacting protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034022.2 → NP_001029194.1 myosin phosphatase Rho-interacting protein isoform 3

See identical proteins and their annotated locations for NP_001029194.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q4KM03, Q9ERE6

Conserved Domains (3) summary

cd01236
Location:16 → 151

PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain

cd13275
Location:358 → 459

PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain

TIGR02168
Location:631 → 941

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
NM_001371051.2 → NP_001357980.1 myosin phosphatase Rho-interacting protein isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5ZXY0, A0A8I6A006

Related

ENSRNOP00000084454.1, ENSRNOT00000100281.1

Conserved Domains (4) summary

COG1196
Location:932 → 1219

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01236
Location:16 → 151

PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain

cd13275
Location:512 → 613

PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain

TIGR02168
Location:771 → 1065

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
NM_001414223.1 → NP_001401152.1 myosin phosphatase Rho-interacting protein isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NM_053814.3 → NP_446266.2 myosin phosphatase Rho-interacting protein isoform 2

See identical proteins and their annotated locations for NP_446266.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q4KM03, Q9ERE6

UniProtKB/TrEMBL

A6HF15

Conserved Domains (3) summary

cd01236
Location:16 → 151

PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain

cd13275
Location:394 → 495

PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain

TIGR02168
Location:667 → 977

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

44953472..45073388

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246424.5 → XP_006246486.1 myosin phosphatase Rho-interacting protein isoform X2

See identical proteins and their annotated locations for XP_006246486.1

UniProtKB/TrEMBL

A0A8I5ZXY0, A0A8I6A006

Conserved Domains (4) summary

COG1196
Location:932 → 1219

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01236
Location:16 → 151

PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain

cd13275
Location:512 → 613

PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain

TIGR02168
Location:771 → 1065

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_063268288.1 → XP_063124358.1 myosin phosphatase Rho-interacting protein isoform X1
XM_063268291.1 → XP_063124361.1 myosin phosphatase Rho-interacting protein isoform X6
XM_063268292.1 → XP_063124362.1 myosin phosphatase Rho-interacting protein isoform X8
XM_006246431.5 → XP_006246493.1 myosin phosphatase Rho-interacting protein isoform X11

UniProtKB/Swiss-Prot

Q4KM03, Q9ERE6

UniProtKB/TrEMBL

G3V9F3

Related

ENSRNOP00000045501.4

Conserved Domains (6) summary

cd01236
Location:16 → 151

PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain

cd13275
Location:512 → 613

PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain

pfam00169
Location:512 → 600

PH; PH domain

pfam15619
Location:801 → 1002

Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

cl02488
Location:860 → 1098

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl03951
Location:761 → 879

CDC37_N; Cdc37 N terminal kinase binding
XM_063268295.1 → XP_063124365.1 myosin phosphatase Rho-interacting protein isoform X12
XM_006246425.5 → XP_006246487.1 myosin phosphatase Rho-interacting protein isoform X4

UniProtKB/TrEMBL

A0A0G2JUR5, A0A8I6A006

Related

ENSRNOP00000069198.2

Conserved Domains (5) summary

cd01236
Location:16 → 151

PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain

cd13275
Location:394 → 495

PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain

pfam00169
Location:394 → 482

PH; PH domain

pfam01442
Location:1948 → 2122

Apolipoprotein; Apolipoprotein A1/A4/E domain

pfam17045
Location:820 → 1044

CEP63; Centrosomal protein of 63 kDa
XM_006246432.5 → XP_006246494.1 myosin phosphatase Rho-interacting protein isoform X14

UniProtKB/Swiss-Prot

Q4KM03, Q9ERE6

Conserved Domains (5) summary

cd01236
Location:16 → 151

PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain

cd13275
Location:394 → 495

PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain

pfam00169
Location:394 → 482

PH; PH domain

cl02488
Location:742 → 980

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl03951
Location:643 → 761

CDC37_N; Cdc37 N terminal kinase binding
XM_063268298.1 → XP_063124368.1 myosin phosphatase Rho-interacting protein isoform X16
XM_006246427.5 → XP_006246489.1 myosin phosphatase Rho-interacting protein isoform X7

UniProtKB/TrEMBL

A0A140TA95, A0A8I6A006

Related

ENSRNOP00000004357.7

Conserved Domains (5) summary

cd01236
Location:16 → 151

PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain

cd13275
Location:358 → 459

PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain

pfam00169
Location:358 → 446

PH; PH domain

pfam01442
Location:1912 → 2086

Apolipoprotein; Apolipoprotein A1/A4/E domain

pfam17045
Location:784 → 1008

CEP63; Centrosomal protein of 63 kDa
XM_017596957.3 → XP_017452446.1 myosin phosphatase Rho-interacting protein isoform X18

UniProtKB/Swiss-Prot

Q4KM03, Q9ERE6
XM_063268301.1 → XP_063124371.1 myosin phosphatase Rho-interacting protein isoform X20
XM_063268297.1 → XP_063124367.1 myosin phosphatase Rho-interacting protein isoform X15

UniProtKB/TrEMBL

A6HF15
XM_063268300.1 → XP_063124370.1 myosin phosphatase Rho-interacting protein isoform X19
XM_063268294.1 → XP_063124364.1 myosin phosphatase Rho-interacting protein isoform X10
XM_063268289.1 → XP_063124359.1 myosin phosphatase Rho-interacting protein isoform X3
XM_063268296.1 → XP_063124366.1 myosin phosphatase Rho-interacting protein isoform X13
XM_063268290.1 → XP_063124360.1 myosin phosphatase Rho-interacting protein isoform X5
XM_063268299.1 → XP_063124369.1 myosin phosphatase Rho-interacting protein isoform X17
XM_063268293.1 → XP_063124363.1 myosin phosphatase Rho-interacting protein isoform X9
XM_039085047.2 → XP_038940975.2 myosin phosphatase Rho-interacting protein isoform X9