Numa1 nuclear mitotic apparatus protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Numa1provided by RGD
Official Full Name: nuclear mitotic apparatus protein 1provided by RGD
Primary source: RGD:1308777
See related: Ensembl:ENSRNOG00000000417 AllianceGenome:RGD:1308777
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables microtubule binding activity. Involved in meiotic cell cycle. Located in several cellular components, including neuronal cell body; nuclear matrix; and spindle pole. Colocalizes with spindle microtubule. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human NUMA1 (nuclear mitotic apparatus protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 283.7), Thymus (RPKM 248.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (165709893..165784848)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (156297907..156372855)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (167044544..167091453)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that when the nuclear matrix is isolated in the presence of an RNase inhibitor, both lamins and the nuclear mitotic apparatus protein localize within the electron-dense domains of the internal nuclear matrix.
Title: Unraveling the organization of the internal nuclear matrix: RNA-dependent anchoring of NuMA to a lamin scaffold.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Got153 (e-PCR)
- UniSTS:113502

D1Bda33 (e-PCR)
- UniSTS:239780

AW535302 (e-PCR)
- UniSTS:247214

BF394104 (e-PCR)
- UniSTS:244687

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables dynein complex binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule minus-end binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anastral spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in astral microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in meiotic cell cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in microtubule bundle formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chromosome separation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic spindle elongation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cell cortex	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to spindle pole body	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of metaphase plate congression	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic spindle organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cortical microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule bundle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in lateral cell cortex	ISO Inferred from Sequence Orthology more info
located_in microtubule bundle	ISO Inferred from Sequence Orthology more info
located_in microtubule minus-end	ISO Inferred from Sequence Orthology more info
located_in microtubule plus-end	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle astral microtubule	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle midzone	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in spindle microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole centrosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear mitotic apparatus protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100691.1 → NP_001094161.1 nuclear mitotic apparatus protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AMK5, F7FF45

Related

ENSRNOP00000094619.1, ENSRNOT00000094333.1

Conserved Domains (5) summary

PHA03307
Location:1713 → 1996

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:1115 → 1711

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:530 → 1321

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd22224
Location:6 → 151

HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins

cd22298
Location:1850 → 1908

NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

165709893..165784848

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262821.1 → XP_063118891.1 nuclear mitotic apparatus protein 1 isoform X1
XM_039113343.2 → XP_038969271.1 nuclear mitotic apparatus protein 1 isoform X1

UniProtKB/TrEMBL

F7FF45

Conserved Domains (6) summary

PTZ00121
Location:959 → 1664

PTZ00121; MAEBL; Provisional

PHA03307
Location:1735 → 2018

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:213 → 827

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:530 → 1321

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd22224
Location:6 → 151

HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins

cd22298
Location:1872 → 1930

NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
XM_039113350.2 → XP_038969278.1 nuclear mitotic apparatus protein 1 isoform X2

UniProtKB/TrEMBL

F1LW91, F7FF45

Related

ENSRNOP00000000474.6

Conserved Domains (5) summary

PHA03307
Location:1727 → 2010

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:1115 → 1725

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:530 → 1321

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd22224
Location:6 → 151

HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins

cd22298
Location:1864 → 1922

NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
XM_039113354.2 → XP_038969282.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/TrEMBL

F7FF45

Conserved Domains (5) summary

PHA03307
Location:1721 → 2004

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:1115 → 1666

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:530 → 1321

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd22224
Location:6 → 151

HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins

cd22298
Location:1858 → 1916

NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
XM_039113357.2 → XP_038969285.1 nuclear mitotic apparatus protein 1 isoform X4

UniProtKB/TrEMBL

A0A8I6AMK5, F7FF45

Conserved Domains (5) summary

PHA03307
Location:1713 → 1996

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:1115 → 1711

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:530 → 1321

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd22224
Location:6 → 151

HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins

cd22298
Location:1850 → 1908

NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
XM_039113349.2 → XP_038969277.1 nuclear mitotic apparatus protein 1 isoform X1

UniProtKB/TrEMBL

F7FF45

Conserved Domains (6) summary

PTZ00121
Location:959 → 1664

PTZ00121; MAEBL; Provisional

PHA03307
Location:1735 → 2018

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:213 → 827

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:530 → 1321

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd22224
Location:6 → 151

HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins

cd22298
Location:1872 → 1930

NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
XM_039113344.2 → XP_038969272.1 nuclear mitotic apparatus protein 1 isoform X1

UniProtKB/TrEMBL

F7FF45

Conserved Domains (6) summary

PTZ00121
Location:959 → 1664

PTZ00121; MAEBL; Provisional

PHA03307
Location:1735 → 2018

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:213 → 827

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:530 → 1321

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd22224
Location:6 → 151

HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins

cd22298
Location:1872 → 1930

NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
XM_063262822.1 → XP_063118892.1 nuclear mitotic apparatus protein 1 isoform X2

UniProtKB/TrEMBL

F1LW91
XM_039113345.2 → XP_038969273.1 nuclear mitotic apparatus protein 1 isoform X1

UniProtKB/TrEMBL

F7FF45

Conserved Domains (6) summary

PTZ00121
Location:959 → 1664

PTZ00121; MAEBL; Provisional

PHA03307
Location:1735 → 2018

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:213 → 827

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:530 → 1321

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd22224
Location:6 → 151

HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins

cd22298
Location:1872 → 1930

NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
XM_063262823.1 → XP_063118893.1 nuclear mitotic apparatus protein 1 isoform X4

UniProtKB/TrEMBL

A0A8I6AMK5
XM_039113346.2 → XP_038969274.1 nuclear mitotic apparatus protein 1 isoform X1

UniProtKB/TrEMBL

F7FF45

Conserved Domains (6) summary

PTZ00121
Location:959 → 1664

PTZ00121; MAEBL; Provisional

PHA03307
Location:1735 → 2018

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:213 → 827

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:530 → 1321

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd22224
Location:6 → 151

HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins

cd22298
Location:1872 → 1930

NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins