KLF11 KLF transcription factor 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KLF11provided by HGNC
Official Full Name: KLF transcription factor 11provided by HGNC
Primary source: HGNC:HGNC:11811
See related: Ensembl:ENSG00000172059 MIM:603301; AllianceGenome:HGNC:11811
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FKLF; FKLF1; MODY7; TIEG2; Tieg3
Summary: The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Expression: Ubiquitous expression in testis (RPKM 20.2), lung (RPKM 12.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p25.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (10043550..10054836)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (10072326..10083576)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (10183677..10194963)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maturity-onset diabetes of the young type 7 (MODY7) and mutation in the Kruppel-like transcription factor 11 (KLF11) gene.
Title: Maturity-onset diabetes of the young type 7 (MODY7) and mutation in the Krüppel-like transcription factor 11 (KLF11) gene.
Maturity-onset Diabetes of the Young Type 7 (MODY7) and the Kruppellike Factor 11 Mutation (KLF11). A Review.
Title: Maturity-onset Diabetes of the Young Type 7 (MODY7) and the Krüppellike Factor 11 Mutation (KLF11). A Review.
KLF11 regulates lung adenocarcinoma ferroptosis and chemosensitivity by suppressing GPX4.
Title: KLF11 regulates lung adenocarcinoma ferroptosis and chemosensitivity by suppressing GPX4.
Genetic and Functional Analyses of the Novel KLF11 Pro193Thr Variant in a Three-Generation Family with MODY7.
Title: Genetic and Functional Analyses of the Novel KLF11 Pro193Thr Variant in a Three-Generation Family with MODY7.
Endothelial KLF11 as a Nephroprotectant in AKI.
Title: Endothelial KLF11 as a Nephroprotectant in AKI.
KLF11 Is a Novel Endogenous Protectant against Renal Ischemia-Reperfusion Injury.
Title: KLF11 Is a Novel Endogenous Protectant against Renal Ischemia-Reperfusion Injury.
A novel KLF11 variant in a family with maturity-onset diabetes of the young.
Title: A novel KLF11 variant in a family with maturity-onset diabetes of the young.
KLF11 promotes the progression of glioma via regulating Holliday junction recognition protein.
Title: KLF11 promotes the progression of glioma via regulating Holliday junction recognition protein.
KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression.
Title: KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression.
Evaluation of Evidence for Pathogenicity Demonstrates That BLK, KLF11, and PAX4 Should Not Be Included in Diagnostic Testing for MODY.
Title: Evaluation of Evidence for Pathogenicity Demonstrates That BLK, KLF11, and PAX4 Should Not Be Included in Diagnostic Testing for MODY.

Submit: New GeneRIF Correction See all GeneRIFs (57)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Maturity-onset diabetes of the young type 7 MedGen: C1864839 OMIM: 610508 GeneReviews: Maturity-Onset Diabetes of the Young Overview	Compare labs

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:480520

SHGC-33613 (e-PCR)
- UniSTS:74016

NoName (e-PCR)
- UniSTS:482122

SHGC-36737 (e-PCR)
- UniSTS:11113

RH78629 (e-PCR)
- UniSTS:80550

RH11597 (e-PCR)
- UniSTS:10463

G20404 (e-PCR)
- UniSTS:22253

A005P43 (e-PCR)
- UniSTS:22254

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to peptide	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of chromatin	ISA Inferred from Sequence Alignment more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in focal adhesion	IDA Inferred from Direct Assay more info
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: Krueppel-like factor 11

Names: Kruppel like factor 11; TGFB-inducible early growth response protein 2; TIEG-2; transforming growth factor-beta-inducible early growth response protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_017199.2 RefSeqGene

Range

5002..16288

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001177716.2 → NP_001171187.1 Krueppel-like factor 11 isoform b

See identical proteins and their annotated locations for NP_001171187.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AC104794

Consensus CDS

CCDS54333.1

UniProtKB/TrEMBL

B7ZAX4

Related

ENSP00000444690.1, ENST00000540845.5

Conserved Domains (4) summary

COG5048
Location:376 → 432

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:382 → 401

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:437 → 459

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:423 → 446

zf-H2C2_2; Zinc-finger double domain
NM_001177718.2 → NP_001171189.1 Krueppel-like factor 11 isoform b

See identical proteins and their annotated locations for NP_001171189.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AC104794

Consensus CDS

CCDS54333.1

UniProtKB/TrEMBL

B7ZAX4

Related

ENSP00000442722.1, ENST00000535335.1

Conserved Domains (4) summary

COG5048
Location:376 → 432

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:382 → 401

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:437 → 459

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:423 → 446

zf-H2C2_2; Zinc-finger double domain
NM_003597.5 → NP_003588.1 Krueppel-like factor 11 isoform a

See identical proteins and their annotated locations for NP_003588.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AC104794

Consensus CDS

CCDS1668.1

UniProtKB/Swiss-Prot

B4DZE7, O14901, Q9EPF4

UniProtKB/TrEMBL

B2RCZ6, Q53QU8

Related

ENSP00000307023.1, ENST00000305883.6

Conserved Domains (4) summary

COG5048
Location:393 → 449

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:399 → 418

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:454 → 476

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:440 → 463

zf-H2C2_2; Zinc-finger double domain