CDC23 cell division cycle 23 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CDC23provided by HGNC
Official Full Name: cell division cycle 23provided by HGNC
Primary source: HGNC:HGNC:1724
See related: Ensembl:ENSG00000094880 MIM:603462; AllianceGenome:HGNC:1724
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: APC8; CUT23; ANAPC8
Summary: The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in placenta (RPKM 12.7), testis (RPKM 9.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q31.2

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (138187650..138213323, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (138713942..138739579, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (137523339..137549012, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Homozygous variants in CDC23 cause female infertility characterized by oocyte maturation defects.
Title: Homozygous variants in CDC23 cause female infertility characterized by oocyte maturation defects.
LINC00514 promoted CDC23 expression via restraining miR-204-3p activity, leading to papillary thyroid cancer progression.
Title: Silencing of lncRNA LINC00514 inhibits the malignant behaviors of papillary thyroid cancer through miR-204-3p/CDC23 axis.
Results identified CDC23 as a miR-34c-regulated target that could be responsible for the miR-34c-induced cell cycle arrest.
Title: Expression of miR-34c induces G2/M cell cycle arrest in breast cancer cells.
CDC23 is a critical regulator of cell cycle and cell growth, may be involved in thyroid cancer initiation and progression, and may explain the different tumor biology observed by gender.
Title: CDC23 regulates cancer cell phenotype and is overexpressed in papillary thyroid cancer.
Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A
Title: How APC/C-Cdc20 changes its substrate specificity in mitosis.
We report gene alterations in several components of this complex in human colon cancer cells, including APC6/CDC16 and APC8/CDC23 which are known to be key function elements.
Title: Alterations of anaphase-promoting complex genes in human colon cancer cells.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5S1673E (e-PCR)
- UniSTS:151062

WI-14323 (e-PCR)
- UniSTS:83278

RH44568 (e-PCR)
- UniSTS:56464

RH48461 (e-PCR)
- UniSTS:69032

RH48651 (e-PCR)
- UniSTS:79834

RH91186 (e-PCR)
- UniSTS:85223

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in anaphase-promoting complex-dependent catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in anaphase-promoting complex-dependent catabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in cell division	IBA Inferred from Biological aspect of Ancestor more info
involved_in metaphase/anaphase transition of mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic metaphase chromosome alignment	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mitotic metaphase/anaphase transition	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K11-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K48-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of exit from mitosis	TAS Traceable Author Statement more info	PubMed
involved_in regulation of meiotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of mitotic metaphase/anaphase transition	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of anaphase-promoting complex	IDA Inferred from Direct Assay more info	PubMed
part_of anaphase-promoting complex	IPI Inferred from Physical Interaction more info	PubMed
part_of anaphase-promoting complex	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: cell division cycle protein 23 homolog

Names: anaphase-promoting complex subunit 8; cell division cycle 23 homolog; cyclosome subunit 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004661.4 → NP_004652.2 cell division cycle protein 23 homolog

See identical proteins and their annotated locations for NP_004652.2

Status: REVIEWED

Source sequence(s)

AC106752, BC017713

Consensus CDS

CCDS4200.2

UniProtKB/Swiss-Prot

A8K6E5, B4E3A2, B7WP05, D3DQB7, O75433, Q53FN2, Q9BS73, Q9UJX2

Related

ENSP00000378350.2, ENST00000394886.7

Conserved Domains (3) summary

COG2956
Location:214 → 491

YciM; Lipopolysaccharide biosynthesis regulator YciM, contains six TPR domains and a predicted metal-binding C-terminal domain [Cell wall/membrane/envelope biogenesis]

sd00006
Location:367 → 393

TPR; TPR repeat [structural motif]

pfam04049
Location:45 → 148

ANAPC8; Anaphase promoting complex subunit 8 / Cdc23