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    NPIPB15 nuclear pore complex interacting protein family member B15 [ Homo sapiens (human) ]

    Gene ID: 440348, updated on 3-Apr-2024

    Summary

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    Official Symbol
    NPIPB15provided by HGNC
    Official Full Name
    nuclear pore complex interacting protein family member B15provided by HGNC
    Primary source
    HGNC:HGNC:34409
    See related
    Ensembl:ENSG00000196436 AllianceGenome:HGNC:34409
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NPIPL2; A-761H5.4
    Summary
    Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 17.7), skin (RPKM 3.0) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    16q23.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (74376306..74392115)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (80194084..80209885)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (74410204..74426013)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 118 Neighboring gene prostate cancer associated HIP1 interacting lncRNA Neighboring gene pyruvate dehydrogenase phosphatase regulatory subunit 2, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:74390671-74391172 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:74402112-74402363 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11107 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:74414879-74415096 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:74431311-74432152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:74433981-74434480 Neighboring gene uncharacterized LOC105376772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:74441122-74442022 Neighboring gene C-type lectin domain family 18 member B Neighboring gene uncharacterized LOC107984827

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Loftus BJ, et al. Genomics, 1999 Sep 15. PMID 10493829
    2. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear pore complex-interacting protein family member B15
    Names
    nuclear pore complex interacting protein-like 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306094.2 → NP_001293023.1  nuclear pore complex-interacting protein family member B15 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001293023.1

      Status: VALIDATED

      Source sequence(s)
      AC009053
      Consensus CDS
      CCDS76897.1
      UniProtKB/Swiss-Prot
      A6NHN6, C9J9U8
      UniProtKB/TrEMBL
      I3L0I5
      Related
      ENSP00000508772.1, ENST00000692376.1
      Conserved Domains (1) summary
      pfam06409
      Location:23 → 299
      NPIP; Nuclear pore complex interacting protein (NPIP)

    2. NM_001385737.1 → NP_001372666.1  nuclear pore complex-interacting protein family member B15 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC009053
      UniProtKB/TrEMBL
      I3L0I5
      Conserved Domains (1) summary
      pfam06409
      Location:37 → 306
      NPIP; Nuclear pore complex interacting protein (NPIP)

    3. NM_001385738.1 → NP_001372667.1  nuclear pore complex-interacting protein family member B15 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009053
      UniProtKB/TrEMBL
      O75199
      Conserved Domains (1) summary
      pfam06409
      Location:12 → 177
      NPIP; Nuclear pore complex interacting protein (NPIP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      74376306..74392115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434161.1 → XP_047290117.1  nuclear pore complex-interacting protein family member B15 isoform X1

    2. XM_017023248.1 → XP_016878737.1  nuclear pore complex-interacting protein family member B15 isoform X2

      UniProtKB/Swiss-Prot
      A6NHN6, C9J9U8
      UniProtKB/TrEMBL
      I3L0I5
      Related
      ENSP00000411140.1, ENST00000429990.1
      Conserved Domains (1) summary
      pfam06409
      Location:23 → 299
      NPIP; Nuclear pore complex interacting protein (NPIP)

    3. XM_047434162.1 → XP_047290118.1  nuclear pore complex-interacting protein family member B15 isoform X3

    4. XM_047434164.1 → XP_047290120.1  nuclear pore complex-interacting protein family member B15 isoform X6

    5. XM_024450290.1 → XP_024306058.1  nuclear pore complex-interacting protein family member B15 isoform X4

      UniProtKB/TrEMBL
      O75199
      Conserved Domains (1) summary
      pfam06409
      Location:23 → 160
      NPIP; Nuclear pore complex interacting protein (NPIP)

    6. XM_047434163.1 → XP_047290119.1  nuclear pore complex-interacting protein family member B15 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      80194084..80209885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380384.1 → XP_054236359.1  nuclear pore complex-interacting protein family member B15 isoform X2

      UniProtKB/Swiss-Prot
      A6NHN6, C9J9U8

    2. XM_054380385.1 → XP_054236360.1  nuclear pore complex-interacting protein family member B15 isoform X4

    3. XM_054380386.1 → XP_054236361.1  nuclear pore complex-interacting protein family member B15 isoform X7

    4. XM_054380387.1 → XP_054236362.1  nuclear pore complex-interacting protein family member B15 isoform X6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001018059.2: Suppressed sequence

      Description
      NM_001018059.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NHN6.3 GenPept UniProtKB/Swiss-Prot:A6NHN6

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