nrxn1a neurexin 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nrxn1aprovided by ZNC
Official Full Name: neurexin 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070206-1
See related: Ensembl:ENSDARG00000061647 AllianceGenome:ZFIN:ZDB-GENE-070206-1
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. In zebrafish, morpholino knockdown of an alpha isoform results in defects in balance and reduced locomotor activity. Knockdown of a beta isoform results in defects in sprouting angiogenesis and vascular remodeling. Alternative splicing and promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2016]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (24342300..24637303)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (24221084..24515930)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coinjection of low doses of morpholinos for beta-neurexin 1a and neuroligin 1 together or in combination with morpholinos targeting the -heparin--binding isoforms of vascular endothelial growth factor A recapitulates the observed abnormalities
Title: The synaptic proteins β-neurexin and neuroligin synergize with extracellular matrix-binding vascular endothelial growth factor a during zebrafish vascular development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neurexin 1a

Names: neurexin Ia-alpha; neurexin Ia-beta; neurexin-1a-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080021.2 → NP_001073490.1 neurexin 1a isoform 1 precursor

See identical proteins and their annotated locations for NP_001073490.1

Status: REVIEWED

Source sequence(s)

AL928656, BX255907, CR933760

UniProtKB/Swiss-Prot

A1XQX0

Related

ENSDARP00000102322.4, ENSDART00000111239.4

Conserved Domains (6) summary

smart00294
Location:1436 → 1454

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:490 → 641

LamG; Laminin G domain

cd00054
Location:669 → 702

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1404 → 1469

Syndecan; Syndecan domain

pfam02210
Location:922 → 1050

Laminin_G_2; Laminin G domain
NM_001346923.1 → NP_001333852.1 neurexin 1a isoform 2 precursor

Status: REVIEWED

Source sequence(s)

BX255907, CR933760

UniProtKB/Swiss-Prot

A1XQX1

Related

ENSDARP00000082592.3, ENSDART00000088159.5
NM_001346924.1 → NP_001333853.1 neurexin 1a isoform 3 precursor

Status: REVIEWED

Source sequence(s)

BX255907, CR933760

UniProtKB/TrEMBL

A0A8M1PAN0, B6EUL5

Related

ENSDARP00000056255.4, ENSDART00000056256.6

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

24342300..24637303

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009306641.3 → XP_009304916.1 neurexin 1a isoform X1

UniProtKB/TrEMBL

A0A8M3B7D6

Conserved Domains (6) summary

smart00294
Location:1442 → 1460

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 634

LamG; Laminin G domain

cd00054
Location:662 → 695

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1410 → 1475

Syndecan; Syndecan domain

pfam02210
Location:915 → 1043

Laminin_G_2; Laminin G domain
XM_009306652.3 → XP_009304927.1 neurexin 1a isoform X17

UniProtKB/TrEMBL

A0A8M3B7E5

Conserved Domains (6) summary

smart00294
Location:1412 → 1430

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 634

LamG; Laminin G domain

cd00054
Location:662 → 695

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1380 → 1445

Syndecan; Syndecan domain

pfam02210
Location:915 → 1043

Laminin_G_2; Laminin G domain
XM_009306653.3 → XP_009304928.1 neurexin 1a isoform X18

UniProtKB/TrEMBL

A0A8M3B4L5

Conserved Domains (6) summary

smart00294
Location:1409 → 1427

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 634

LamG; Laminin G domain

cd00054
Location:662 → 695

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1377 → 1442

Syndecan; Syndecan domain

pfam02210
Location:915 → 1043

Laminin_G_2; Laminin G domain
XM_005156209.4 → XP_005156266.1 neurexin 1a isoform X9

UniProtKB/TrEMBL

A0A8M2B276

Conserved Domains (6) summary

smart00294
Location:1433 → 1451

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 634

LamG; Laminin G domain

cd00054
Location:662 → 695

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1401 → 1466

Syndecan; Syndecan domain

pfam02210
Location:915 → 1043

Laminin_G_2; Laminin G domain
XM_009306644.3 → XP_009304919.1 neurexin 1a isoform X4

UniProtKB/TrEMBL

A0A8M3BE52

Conserved Domains (6) summary

smart00294
Location:1438 → 1456

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 634

LamG; Laminin G domain

cd00054
Location:662 → 695

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1406 → 1471

Syndecan; Syndecan domain

pfam02210
Location:915 → 1043

Laminin_G_2; Laminin G domain
XM_009306654.3 → XP_009304929.1 neurexin 1a isoform X19

UniProtKB/TrEMBL

A0A8M3AYD0

Conserved Domains (6) summary

smart00294
Location:1399 → 1417

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 634

LamG; Laminin G domain

cd00054
Location:662 → 695

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1367 → 1432

Syndecan; Syndecan domain

pfam02210
Location:915 → 1043

Laminin_G_2; Laminin G domain
XM_009306656.3 → XP_009304931.1 neurexin 1a isoform X26

UniProtKB/TrEMBL

A0A8M3BE57

Conserved Domains (6) summary

smart00294
Location:1396 → 1414

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 634

LamG; Laminin G domain

cd00054
Location:662 → 695

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1364 → 1429

Syndecan; Syndecan domain

pfam02210
Location:915 → 1043

Laminin_G_2; Laminin G domain
XM_009306650.3 → XP_009304925.1 neurexin 1a isoform X10

UniProtKB/TrEMBL

A0A8M3BE54

Conserved Domains (6) summary

smart00294
Location:1433 → 1451

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 634

LamG; Laminin G domain

cd00054
Location:662 → 695

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1401 → 1466

Syndecan; Syndecan domain

pfam02210
Location:906 → 1034

Laminin_G_2; Laminin G domain
XM_021480139.1 → XP_021335814.1 neurexin 1a isoform X15

UniProtKB/TrEMBL

A0A8M9QED3

Related

ENSDARP00000154048.1, ENSDART00000183180.1

Conserved Domains (6) summary

smart00294
Location:1420 → 1438

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 634

LamG; Laminin G domain

cd00054
Location:662 → 695

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1388 → 1453

Syndecan; Syndecan domain

pfam02210
Location:906 → 1034

Laminin_G_2; Laminin G domain
XM_021480141.1 → XP_021335816.1 neurexin 1a isoform X20

UniProtKB/TrEMBL

A0A8M9QIT8

Conserved Domains (6) summary

smart00294
Location:1390 → 1408

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 634

LamG; Laminin G domain

cd00054
Location:662 → 695

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1358 → 1423

Syndecan; Syndecan domain

pfam02210
Location:906 → 1034

Laminin_G_2; Laminin G domain
XM_009306649.3 → XP_009304924.1 neurexin 1a isoform X8

UniProtKB/TrEMBL

A0A8M3AYC5

Conserved Domains (6) summary

smart00294
Location:1434 → 1452

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:475 → 626

LamG; Laminin G domain

cd00054
Location:654 → 687

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1402 → 1467

Syndecan; Syndecan domain

pfam02210
Location:907 → 1035

Laminin_G_2; Laminin G domain
XM_009306645.3 → XP_009304920.1 neurexin 1a isoform X5

UniProtKB/TrEMBL

A0A8M3AY99

Conserved Domains (6) summary

smart00294
Location:1438 → 1456

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:479 → 630

LamG; Laminin G domain

cd00054
Location:658 → 691

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1406 → 1471

Syndecan; Syndecan domain

pfam02210
Location:911 → 1039

Laminin_G_2; Laminin G domain
XM_009306642.3 → XP_009304917.1 neurexin 1a isoform X2

UniProtKB/TrEMBL

A0A8M3B4K7

Conserved Domains (6) summary

smart00294
Location:1441 → 1459

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:482 → 633

LamG; Laminin G domain

cd00054
Location:661 → 694

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1409 → 1474

Syndecan; Syndecan domain

pfam02210
Location:914 → 1042

Laminin_G_2; Laminin G domain
XM_009306646.3 → XP_009304921.1 neurexin 1a isoform X6

UniProtKB/TrEMBL

A0A8M3B7E0

Conserved Domains (6) summary

smart00294
Location:1437 → 1455

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:478 → 629

LamG; Laminin G domain

cd00054
Location:657 → 690

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1405 → 1470

Syndecan; Syndecan domain

pfam02210
Location:910 → 1038

Laminin_G_2; Laminin G domain
XM_009306648.3 → XP_009304923.1 neurexin 1a isoform X7

UniProtKB/TrEMBL

A0A8M3B4L1

Conserved Domains (6) summary

smart00294
Location:1436 → 1454

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:477 → 628

LamG; Laminin G domain

cd00054
Location:656 → 689

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1404 → 1469

Syndecan; Syndecan domain

pfam02210
Location:909 → 1037

Laminin_G_2; Laminin G domain
XM_021480136.1 → XP_021335811.1 neurexin 1a isoform X11

UniProtKB/TrEMBL

A0A8M9QIT3

Conserved Domains (6) summary

smart00294
Location:1432 → 1450

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:473 → 624

LamG; Laminin G domain

cd00054
Location:652 → 685

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1400 → 1465

Syndecan; Syndecan domain

pfam02210
Location:905 → 1033

Laminin_G_2; Laminin G domain
XM_021480138.1 → XP_021335813.1 neurexin 1a isoform X14

UniProtKB/TrEMBL

A0A8M9Q8I0

Related

ENSDARP00000151175.1, ENSDART00000191648.1

Conserved Domains (6) summary

smart00294
Location:1422 → 1440

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:463 → 614

LamG; Laminin G domain

cd00054
Location:642 → 675

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1390 → 1455

Syndecan; Syndecan domain

pfam02210
Location:895 → 1023

Laminin_G_2; Laminin G domain
XM_021480146.1 → XP_021335821.1 neurexin 1a isoform X25

UniProtKB/TrEMBL

A0A8M9QIU1

Conserved Domains (6) summary

smart00294
Location:1367 → 1385

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:463 → 614

LamG; Laminin G domain

cd00054
Location:642 → 675

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1335 → 1400

Syndecan; Syndecan domain

pfam02210
Location:886 → 1014

Laminin_G_2; Laminin G domain
XM_021480142.1 → XP_021335817.1 neurexin 1a isoform X21

UniProtKB/TrEMBL

A0A8M9PWG1

Conserved Domains (6) summary

smart00294
Location:1362 → 1380

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:455 → 606

LamG; Laminin G domain

cd00054
Location:634 → 667

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1330 → 1395

Syndecan; Syndecan domain

pfam02210
Location:878 → 1006

Laminin_G_2; Laminin G domain
XM_021480145.1 → XP_021335820.1 neurexin 1a isoform X24

UniProtKB/TrEMBL

A0A8M9QML2

Conserved Domains (6) summary

smart00294
Location:1359 → 1377

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:455 → 606

LamG; Laminin G domain

cd00054
Location:634 → 667

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1327 → 1392

Syndecan; Syndecan domain

pfam02210
Location:878 → 1006

Laminin_G_2; Laminin G domain
XM_009306643.3 → XP_009304918.1 neurexin 1a isoform X3

UniProtKB/TrEMBL

A0A8M3AYC2

Conserved Domains (6) summary

smart00294
Location:1439 → 1457

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 634

LamG; Laminin G domain

cd00054
Location:662 → 695

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1407 → 1472

Syndecan; Syndecan domain

pfam02210
Location:915 → 1043

Laminin_G_2; Laminin G domain
XM_021480143.1 → XP_021335818.1 neurexin 1a isoform X22

UniProtKB/TrEMBL

A0A8M9Q8I6

Related

ENSDARP00000082611.6, ENSDART00000088178.7

Conserved Domains (6) summary

smart00294
Location:1416 → 1434

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:473 → 624

LamG; Laminin G domain

cd00054
Location:652 → 685

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1384 → 1449

Syndecan; Syndecan domain

pfam02210
Location:905 → 1033

Laminin_G_2; Laminin G domain
XM_021480144.1 → XP_021335819.1 neurexin 1a isoform X23

UniProtKB/TrEMBL

A0A8M9QED6

Conserved Domains (6) summary

smart00294
Location:1400 → 1418

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:463 → 614

LamG; Laminin G domain

cd00054
Location:642 → 675

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1368 → 1433

Syndecan; Syndecan domain

pfam02210
Location:886 → 1014

Laminin_G_2; Laminin G domain
XM_021480137.1 → XP_021335812.1 neurexin 1a isoform X12

UniProtKB/TrEMBL

A0A140TAU1, A0A8M9PWF5

Related

ENSDARP00000087526.6, ENSDART00000093094.7

Conserved Domains (6) summary

smart00294
Location:1429 → 1447

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 634

LamG; Laminin G domain

cd00054
Location:662 → 695

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1397 → 1462

Syndecan; Syndecan domain

pfam02210
Location:915 → 1043

Laminin_G_2; Laminin G domain
XM_021480140.1 → XP_021335815.1 neurexin 1a isoform X16

UniProtKB/TrEMBL

A0A8M9QML0

Conserved Domains (6) summary

smart00294
Location:1417 → 1435

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:471 → 622

LamG; Laminin G domain

cd00054
Location:650 → 683

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1385 → 1450

Syndecan; Syndecan domain

pfam02210
Location:903 → 1031

Laminin_G_2; Laminin G domain
XM_009306651.3 → XP_009304926.1 neurexin 1a isoform X13

UniProtKB/TrEMBL

A0A2R8QKE7, A0A8M3AYA5

Related

ENSDARP00000152871.1, ENSDART00000189696.1

Conserved Domains (6) summary

smart00294
Location:1426 → 1444

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 634

LamG; Laminin G domain

cd00054
Location:662 → 695

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:27 → 185

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1394 → 1459

Syndecan; Syndecan domain

pfam02210
Location:915 → 1043

Laminin_G_2; Laminin G domain