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    dmd dystrophin [ Chiloscyllium plagiosum (whitespotted bambooshark) ]

    Gene ID: 122555071, updated on 22-Mar-2024

    Summary

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    Gene symbol
    dmd
    Gene description
    dystrophin
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Chiloscyllium plagiosum
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae; Chiloscyllium
    Orthologs
    human zebrafish all
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    Genomic context

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    See dmd in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    83
    Annotation release Status Assembly Chr Location
    100 current ASM401019v2 (GCF_004010195.1) 12 NC_057721.1 (23024854..25037081)

    Chromosome 12 - NC_057721.1Genomic Context describing neighboring genes Neighboring gene wnt inhibitory factor 1-like Neighboring gene transmembrane protein 47 Neighboring gene uncharacterized LOC122555073 Neighboring gene uncharacterized LOC122555072 Neighboring gene uncharacterized LOC122555076 Neighboring gene centrosome-associated protein 350-like Neighboring gene TGF-beta activated kinase 1 (MAP3K7) binding protein 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_057721.1 Chromosome 12 Reference ASM401019v2 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dystrophin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Chiloscyllium plagiosum Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM401019v2 Primary Assembly

    Genomic

    1. NC_057721.1 Reference ASM401019v2 Primary Assembly

      Range
      23024854..25037081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_043700735.1 → XP_043556670.1  dystrophin isoform X3

      Conserved Domains (6) summary
      COG5069
      Location:29 → 249
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:351 → 569
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:3145 → 3184
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:3407 → 3455
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16246
      Location:3221 → 3382
      EFh_DMD; EF-hand-like motif found in dystrophin
      cl02488
      Location:1512 → 1693
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    2. XM_043700733.1 → XP_043556668.1  dystrophin isoform X1

      Conserved Domains (6) summary
      COG5069
      Location:29 → 249
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:351 → 569
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:3145 → 3184
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:3407 → 3455
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16246
      Location:3221 → 3382
      EFh_DMD; EF-hand-like motif found in dystrophin
      cl02488
      Location:1512 → 1693
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    3. XM_043700734.1 → XP_043556669.1  dystrophin isoform X2

      Conserved Domains (6) summary
      COG5069
      Location:29 → 249
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:351 → 569
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:3145 → 3174
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:3397 → 3445
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16246
      Location:3211 → 3372
      EFh_DMD; EF-hand-like motif found in dystrophin
      cl02488
      Location:1512 → 1693
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    4. XM_043700736.1 → XP_043556671.1  dystrophin isoform X4

      Conserved Domains (6) summary
      COG5069
      Location:29 → 249
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:314 → 532
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:3108 → 3147
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:3370 → 3418
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16246
      Location:3184 → 3345
      EFh_DMD; EF-hand-like motif found in dystrophin
      cl02488
      Location:1475 → 1656
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    5. XM_043700737.1 → XP_043556672.1  dystrophin isoform X5

      Conserved Domains (6) summary
      COG5069
      Location:29 → 249
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:351 → 569
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:3062 → 3101
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:3324 → 3372
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      TIGR02169
      Location:1294 → 1963
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cd16246
      Location:3138 → 3299
      EFh_DMD; EF-hand-like motif found in dystrophin

    6. XM_043700738.1 → XP_043556673.1  dystrophin isoform X6

      Conserved Domains (3) summary
      COG1196
      Location:367 → 537
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:243 → 291
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16246
      Location:57 → 218
      EFh_DMD; EF-hand-like motif found in dystrophin
    Nucleotide Protein
    Heading Accession and Version

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