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    PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 [ Homo sapiens (human) ]

    Gene ID: 23533, updated on 23-Nov-2021

    Summary

    Official Symbol
    PIK3R5provided by HGNC
    Official Full Name
    phosphoinositide-3-kinase regulatory subunit 5provided by HGNC
    Primary source
    HGNC:HGNC:30035
    See related
    Ensembl:ENSG00000141506 MIM:611317
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p101; FOAP-2; P101-PI3K; F730038I15Rik
    Summary
    Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]
    Expression
    Biased expression in bone marrow (RPKM 25.8), spleen (RPKM 14.1) and 13 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PIK3R5 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8878916..8965707, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8782233..8869024, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 6 like Neighboring gene phosphoinositide-3-kinase regulatory subunit 6 Neighboring gene uncharacterized LOC107985071 Neighboring gene uncharacterized LOC107985063 Neighboring gene PIK3R5 divergent transcript Neighboring gene netrin 1 Neighboring gene uncharacterized LOC101928266

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ26116

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables G-protein beta/gamma-subunit complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylinositol 3-kinase signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein kinase B signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of phosphatidylinositol 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IB ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    phosphoinositide 3-kinase regulatory subunit 5
    Names
    PI3-kinase p101 subunit
    phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit
    protein FOAP-2
    ptdIns-3-kinase p101

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030374.1 RefSeqGene

      Range
      5001..91797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142633.3NP_001136105.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 1

      See identical proteins and their annotated locations for NP_001136105.1

      Status: REVIEWED

      Source sequence(s)
      AB028925, AK309074, AY725854, BC028212
      Consensus CDS
      CCDS11147.1
      UniProtKB/Swiss-Prot
      Q8WYR1
      UniProtKB/TrEMBL
      L7RT34
      Related
      ENSP00000392812.1, ENST00000447110.6
      Conserved Domains (1) summary
      pfam10486
      Location:6880
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
    2. NM_001251851.2NP_001238780.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

      See identical proteins and their annotated locations for NP_001238780.1

      Status: REVIEWED

      Source sequence(s)
      AF128881, AK309074, AY725851, BC028212
      Consensus CDS
      CCDS73986.1
      UniProtKB/Swiss-Prot
      Q8WYR1
      Conserved Domains (1) summary
      pfam10486
      Location:1494
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
    3. NM_001251852.2NP_001238781.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

      See identical proteins and their annotated locations for NP_001238781.1

      Status: REVIEWED

      Source sequence(s)
      AF128881, AK309074, BC028212
      Consensus CDS
      CCDS73986.1
      UniProtKB/Swiss-Prot
      Q8WYR1
      Related
      ENSP00000484211.1, ENST00000616147.4
      Conserved Domains (1) summary
      pfam10486
      Location:1494
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
    4. NM_001251853.2NP_001238782.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

      See identical proteins and their annotated locations for NP_001238782.1

      Status: REVIEWED

      Source sequence(s)
      AB028925, AF128881, AK309074, AY725852, BC028212
      Consensus CDS
      CCDS73986.1
      UniProtKB/Swiss-Prot
      Q8WYR1
      Related
      ENSP00000477795.1, ENST00000611902.4
      Conserved Domains (1) summary
      pfam10486
      Location:1494
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
    5. NM_001251855.2NP_001238784.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

      See identical proteins and their annotated locations for NP_001238784.1

      Status: REVIEWED

      Source sequence(s)
      AF128881, AK309074, BC028212
      Consensus CDS
      CCDS73986.1
      UniProtKB/Swiss-Prot
      Q8WYR1
      Related
      ENSP00000485280.1, ENST00000623421.3
      Conserved Domains (1) summary
      pfam10486
      Location:1494
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
    6. NM_001388396.1NP_001375325.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC002091, AC003695
      Related
      ENSP00000462680.1, ENST00000584803.1
      Conserved Domains (1) summary
      pfam10486
      Location:6879
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
    7. NM_001388397.1NP_001375326.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC002091, AC003695
      Conserved Domains (1) summary
      pfam10486
      Location:1494
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
    8. NM_001388398.1NP_001375327.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC002091, AC003695
      Conserved Domains (1) summary
      pfam10486
      Location:1494
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
    9. NM_001388399.1NP_001375328.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC002091, AC003695
      Conserved Domains (1) summary
      pfam10486
      Location:1494
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
    10. NM_001388400.1NP_001375329.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC002091, AC003695
      Conserved Domains (1) summary
      pfam10486
      Location:1493
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
    11. NM_014308.4NP_055123.2  phosphoinositide 3-kinase regulatory subunit 5 isoform 1

      See identical proteins and their annotated locations for NP_055123.2

      Status: REVIEWED

      Source sequence(s)
      AF128881, BC028212
      Consensus CDS
      CCDS11147.1
      UniProtKB/Swiss-Prot
      Q8WYR1
      UniProtKB/TrEMBL
      L7RT34
      Related
      ENSP00000462433.1, ENST00000581552.5
      Conserved Domains (1) summary
      pfam10486
      Location:6880
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      8878916..8965707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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