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    CD302 CD302 molecule [ Homo sapiens (human) ]

    Gene ID: 9936, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CD302provided by HGNC
    Official Full Name
    CD302 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:30843
    See related
    Ensembl:ENSG00000241399 MIM:612246; AllianceGenome:HGNC:30843
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DCL1; DCL-1; BIMLEC; CLEC13A
    Summary
    CD302 is a C-type lectin receptor involved in cell adhesion and migration, as well as endocytosis and phagocytosis (Kato et al., 2007 [PubMed 17947679]).[supplied by OMIM, Aug 2008]
    Expression
    Ubiquitous expression in liver (RPKM 51.3), lung (RPKM 34.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    2q24.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (159768628..159798208, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (160225996..160255550, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (160625139..160654719, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain 2B Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160472595-160473121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:160480245-160480746 Neighboring gene BAZ2B antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160568592-160569258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12044 Neighboring gene RPS3A pseudogene 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160594100-160595092 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53909 Neighboring gene membrane associated ring-CH-type finger 7 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53950 Neighboring gene LY75-CD302 readthrough Neighboring gene uncharacterized LOC124906083 Neighboring gene lymphocyte antigen 75 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16695 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:160761228-160761469 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16696 Neighboring gene phospholipase A2 receptor 1 Neighboring gene uncharacterized LOC105373717 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:160911725-160912406

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Human Liver-Expressed Lectin CD302 Restricts Hepatitis C Virus Infection. Reinecke B, et al. J Virol, 2022 Apr 13. PMID 35297672, Free PMC Article
    2. Particle Morphology of Medusavirus Inside and Outside the Cells Reveals a New Maturation Process of Giant Viruses. Watanabe R, et al. J Virol, 2022 Apr 13. PMID 35297671, Free PMC Article
    3. Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration. Lo TH, et al. J Immunol, 2016 Aug 1. PMID 27316686
    4. Characterization of DLC1-SAM equilibrium unfolding at the amino acid residue level. Yang S, et al. Biochemistry, 2009 May 19. PMID 19317456
    5. Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1. Kato M, et al. J Biol Chem, 2003 Sep 5. PMID 12824192

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Human Liver-Expressed Lectin CD302 Restricts Hepatitis C Virus Infection.
      Title: The Human Liver-Expressed Lectin CD302 Restricts Hepatitis C Virus Infection.
    2. Particle Morphology of Medusavirus Inside and Outside the Cells Reveals a New Maturation Process of Giant Viruses.
      Title: Particle Morphology of Medusavirus Inside and Outside the Cells Reveals a New Maturation Process of Giant Viruses.
    3. DLC1 equilibrium unfolding is characterized at the amino acid level.
      Title: Characterization of DLC1-SAM equilibrium unfolding at the amino acid residue level.
    4. These studies confirm a functional role for CD302 in myeloid dendritic cells migration.
      Title: Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    6. hDCL-1 is an unconventional lectin receptor that plays roles not only in endocytosis/phagocytosis but also in cell adhesion and migration
      Title: The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration.
    7. Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1
      Title: Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of CD302 (DCL1) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough LY75-CD302

    Readthrough gene: LY75-CD302, Included gene: LY75

    Homology

    Clone Names

    • FLJ43091, KIAA0022, MGC22301

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phagocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in microvillus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CD302 antigen
    Names
    C-type lectin domain family 13, member A
    DEC205-associated C-type lectin 1
    type I transmembrane C-type lectin receptor DCL-1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198763.2 → NP_001185692.1  CD302 antigen isoform 2 precursor

      See identical proteins and their annotated locations for NP_001185692.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC009961, AK304422, CB240843
      Consensus CDS
      CCDS56139.1
      UniProtKB/Swiss-Prot
      Q8IX05
      Related
      ENSP00000394301.2, ENST00000429078.6
      Conserved Domains (1) summary
      smart00034
      Location:24 → 98
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

    2. NM_001198764.2 → NP_001185693.1  CD302 antigen isoform 3 precursor

      See identical proteins and their annotated locations for NP_001185693.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AC009961, CB240843, DB460994
      Consensus CDS
      CCDS74595.1
      UniProtKB/TrEMBL
      A0A087WT00
      Related
      ENSP00000451446.2, ENST00000553424.5
      Conserved Domains (1) summary
      smart00034
      Location:25 → 117
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

    3. NM_014880.5 → NP_055695.2  CD302 antigen isoform 1 precursor

      See identical proteins and their annotated locations for NP_055695.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC009961, AK291279, AY314007, CB240843
      Consensus CDS
      CCDS33308.1
      UniProtKB/Swiss-Prot
      A8K5G4, B4E2T9, Q15009, Q8IX05
      Related
      ENSP00000259053.4, ENST00000259053.6
      Conserved Domains (1) summary
      smart00034
      Location:24 → 154
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      159768628..159798208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      160225996..160255550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IX05.1 GenPept UniProtKB/Swiss-Prot:Q8IX05

    Gene LinkOut

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