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Series GSE13864 Query DataSets for GSE13864
Status Public on May 01, 2009
Title Effect of conditional deletion of S6 ribosomal protein following partial hepatectomy
Organism Mus musculus
Experiment type Expression profiling by array
Summary Deletion of the RPS6 gene in mouse liver results in the inhibition of 40S ribosome biogenesis and the failure of hepatocytes to enter S-phase following partial hepatectomy. This microarray experiment was designed to assess the effects of RPS6 deletion on the expression of genes involved in liver regeneration following partial hepatectomy.

Keywords: time course, liver
 
Overall design RNA was isolated from mouse livers at different time-points following partial hepatectomy. Conditional deletion of the RPS6 gene was perfomed by injecting polyinosinic-polycytidylic acid in mice harbouring a floxed version of the RPS6 gene and a cre recombinase under the regulation of an interferon responsive promoter (MX-CRE). The mice used a control have also a floxed version of the RPS6 gene but lack the cre recombinaste transgene.
 
Contributor(s) Di Cara A, Fumagalli S, Oakeley EJ, Thomas G
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Submission date Dec 08, 2008
Last update date Feb 18, 2018
Contact name Alessandro Di Cara
E-mail(s) ale@di-cara.com
Organization name Friedrich Miescher Institute
Street address Maulbeerstrasse 66
City Basel
ZIP/Postal code 4058
Country Switzerland
 
Platforms (1)
GPL81 [MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Samples (32)
GSM348487 liver sample time 0.0 hours mx-cre MINUS replicate A batch PHX3
GSM348488 liver sample time 0.0 hours mx-cre MINUS replicate B batch PHX2
GSM348489 liver sample time 0.0 hours mx-cre MINUS replicate C batch PHX3
Relations
BioProject PRJNA110463

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE13864_RAW.tar 87.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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