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| Status |
Public on Apr 01, 2010 |
| Title |
Transcriptome analysis reveals a major impact of Tyk2 on the expression of interferon responsive and metabolic genes |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Peritoneal macrophages of Tyk2-/- and wildtype (wt) mice were compared before and after six hours of LPS treatment. Interferon responsive genes are lower expressed in Tyk2-/- macrophages at the basal level, metabolic genes higher before, but even more after LPS treatment.
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| Overall design |
cDNA from macrophages from three replicates of three Tyk2-/- and three wt mice before and after six hours of LPS treatment, respectively, was hybridized to a microarray and analyzed.
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| Contributor(s) |
Vogl C, Flatt T, Fuhrmann B, Hofmann E, Wallner B, Stiefvater R, Kovarik P, Strobl B, Müller M |
| Citation(s) |
20338026 |
| Submission date |
Jan 04, 2010 |
| Last update date |
Mar 21, 2012 |
| Contact name |
Claus Vogl |
| E-mail(s) |
claus.vogl@vetmeduni.ac.at
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| Phone |
+43-1-250775631
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| Organization name |
University of Veterinary Medicine, Vienna
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| Department |
Biomedical Sciences
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| Lab |
Animal Breeding and Genetics
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| Street address |
Veterinaerplatz 1
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| City |
Vienna |
| State/province |
Vienna |
| ZIP/Postal code |
A-1210 |
| Country |
Austria |
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| Platforms (1) |
| GPL8063 |
GE Healthcare/Amersham Biosciences CodeLink™ Mouse Whole Genome Bioarray |
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| Samples (12)
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| GSM492790 |
Tyk2-/-, mouse 1, 6h LPS |
| GSM492791 |
WT, mouse 2, 6h LPS |
| GSM492792 |
WT, mouse 2, 0 LPS |
| GSM492793 |
Tyk2-/-, mouse 2, 0 LPS |
| GSM492794 |
Tyk2-/-, mouse 2, 6h LPS |
| GSM492795 |
WT, mouse 3, 0 LPS |
| GSM492796 |
WT, mouse 3, 6h LPS |
| GSM492797 |
Tyk2-/-, mouse 3, 0 LPS |
| GSM492798 |
Tyk2-/-, mouse 3, 6h LPS |
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| Relations |
| BioProject |
PRJNA122191 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE19733_RAW.tar |
17.1 Mb |
(http)(custom) |
TAR (of TXT) |
| GSE19733_results_file.txt.gz |
1.1 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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