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| Status |
Public on May 12, 2010 |
| Title |
DNA methylation in progenitor cells: expression study |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We surveyed DNA methylation profiles of all human RefSeq promoters in relation to gene expression and differentiation in adipose tissue, bone marrow and muscle mesenchymal progenitors, as well as in bone marrow-derived hematopoietic progenitors. We unravel strongly overlapping DNA methylation profiles between adipose stem cells (ASCs), bone marrow mesenchymal stem cells (BMMSCs) and muscle progenitor cells (MPCs), while hematopoietic progenitor cells (HPCs) are more epigenetically distant from MSCs seen as a whole. Differentiation resolves a fraction of methylation patterns common to MSCs, generating epigenetic divergence.
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| Overall design |
RNA was isolated from MSCs isolated from various tissues and from differentiated cells, and hybridized onto Illumina expression arrays. 2-3 replicates per cell type.
The supplementary file 'GSE19773_non-normalized.txt' contains the non-normalized data for Samples GSM493884-GSM493894.
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| Contributor(s) |
Reiner AH, Jacobsen BM |
| Citation(s) |
20410135 |
| Submission date |
Jan 06, 2010 |
| Last update date |
Jan 08, 2019 |
| Contact name |
Philippe Collas |
| Organization name |
University of Oslo
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| Department |
Institute of Basic Medical Sciences
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| Street address |
PO Box 1112 Blindern
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| City |
Oslo |
| ZIP/Postal code |
0317 |
| Country |
Norway |
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| Platforms (1) |
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| Samples (11)
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| This SubSeries is part of SuperSeries: |
| GSE19795 |
DNA methylation in progenitor cells |
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| Relations |
| BioProject |
PRJNA124013 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE19773_non-normalized.txt.gz |
3.9 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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