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| Status |
Public on Oct 29, 2014 |
| Title |
Gene expression of CD14- cells from RA, PsA and PsO patients with Infliximab treatment |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
objection: The immune inflammatory disorders rheumatoid arthritis (RA), psoriatic arthritis (PsA) and psoriasis (Ps) share common pathologic features and show responsiveness to anti-tumor necrosis factor (TNF) agents yet they are phenotypically distinct. The aim of this study was to examine if anti-TNF therapy is associated with divergent gene expression profiles in circulating cells and target tissues of patients with these diseases
Method: Peripheral blood CD14+ and CD14- cells were isolated from 9 RA, 12 PsA and 10 Ps patients before and after infliximab (IFX) treatment.
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| Overall design |
Between April 2007 and June 2009, 31 patients with active RA, PsA and Ps who were naïve to anti-TNF agents, were recruited from the Faculty Rheumatology Clinics at the University of Rochester Medical Center after informed, written consent was obtained in a protocol approved by the Research Subjects Review Board at the University of Rochester Medical Center. Of the 31 subjects, 9 had active RA and 12 had PsA despite treatment with Disease Modifying Anti-Rheumatic Drugs (DMARDs). Also, 10 patients with extensive Ps (>5% BSA) documented by a dermatologist, were enrolled and they were examined by a rheumatologist to exclude the presence of inflammatory arthritis. Nineteen healthy controls were also recruited.
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| Contributor(s) |
Dave S, Ritchlin C |
| Citation(s) |
25333715 |
| Submission date |
May 07, 2014 |
| Last update date |
Apr 20, 2018 |
| Contact name |
Christopher Ritchlin |
| E-mail(s) |
Christopher_Ritchlin@URMC.Rochester.edu
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| Phone |
(585) 486-0901
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| Organization name |
University of Rochester Medical Center
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| Department |
School of Medicine and Dentistry
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| Street address |
601 Elmwood Ave, BOX695
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| City |
Rochester |
| State/province |
NY |
| ZIP/Postal code |
14642 |
| Country |
USA |
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| Platforms (1) |
| GPL13158 |
[HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate |
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| Samples (111)
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| This SubSeries is part of SuperSeries: |
| GSE57386 |
Gene expression of biopsies, CD14+ and CD14- cells from RA, PsA and PsO patients with Infliximab treatment |
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| Relations |
| BioProject |
PRJNA246403 |
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