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    rgl3a ral guanine nucleotide dissociation stimulator-like 3a [ Danio rerio (zebrafish) ]

    Gene ID: 100149956, updated on 11-Apr-2024

    Summary

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    Official Symbol
    rgl3aprovided by ZNC
    Official Full Name
    ral guanine nucleotide dissociation stimulator-like 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-101130-1
    See related
    Ensembl:ENSDARG00000071213 AllianceGenome:ZFIN:ZDB-GENE-101130-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within positive regulation of GTPase activity and small GTPase mediated signal transduction. Orthologous to human RGL3 (ral guanine nucleotide dissociation stimulator like 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See rgl3a in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (8210115..8244789, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (7974580..8009834, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene nuclear factor, interleukin 3 regulated, member 3 Neighboring gene nuclear factor, interleukin 3 regulated, member 5 Neighboring gene outer dynein arm docking complex subunit 3 Neighboring gene solute carrier family 44 member 2 (CTL2 blood group)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ral guanine nucleotide dissociation stimulator-like 3; ral guanine nucleotide dissociation stimulator-like 1
    Names
    rgl3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      8210115..8244789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165751.4 → XP_005165808.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X1

      See identical proteins and their annotated locations for XP_005165808.1

      UniProtKB/TrEMBL
      A0A8M2BD17
      Conserved Domains (3) summary
      cd00153
      Location:677 → 763
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:259 → 541
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam00618
      Location:106 → 189
      RasGEF_N; RasGEF N-terminal motif

    2. XM_009302164.3 → XP_009300439.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M3BA68
      Conserved Domains (3) summary
      cd00153
      Location:676 → 762
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:259 → 540
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam00618
      Location:106 → 189
      RasGEF_N; RasGEF N-terminal motif

    3. XM_009302163.3 → XP_009300438.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X1

      See identical proteins and their annotated locations for XP_009300438.1

      UniProtKB/TrEMBL
      A0A8M2BD17
      Conserved Domains (3) summary
      cd00153
      Location:677 → 763
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:259 → 541
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam00618
      Location:106 → 189
      RasGEF_N; RasGEF N-terminal motif

    4. XM_009302166.3 → XP_009300441.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M3B368, I3IT01
      Related
      ENSDARP00000126052.1, ENSDART00000151358.3
      Conserved Domains (3) summary
      cd00153
      Location:674 → 760
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:259 → 540
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam00618
      Location:106 → 189
      RasGEF_N; RasGEF N-terminal motif

    5. XM_009302165.3 → XP_009300440.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AT51
      Conserved Domains (3) summary
      cd00153
      Location:675 → 761
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:259 → 541
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam00618
      Location:106 → 189
      RasGEF_N; RasGEF N-terminal motif

    6. XM_001921184.6 → XP_001921219.3  ral guanine nucleotide dissociation stimulator-like 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M1QUZ8
      Conserved Domains (3) summary
      cd00153
      Location:629 → 715
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:211 → 493
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam00618
      Location:58 → 141
      RasGEF_N; RasGEF N-terminal motif

    7. XM_021476991.1 → XP_021332666.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9QAN2
      Conserved Domains (2) summary
      cd00153
      Location:268 → 354
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      cl02485
      Location:47 → 132
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394626.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      34554..84418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471711.1 → XP_021327386.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q1W3
      Conserved Domains (3) summary
      cd00153
      Location:677 → 763
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:259 → 541
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam00618
      Location:106 → 189
      RasGEF_N; RasGEF N-terminal motif

    2. XM_021471712.1 → XP_021327387.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9P937
      Conserved Domains (3) summary
      cd00153
      Location:676 → 762
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:259 → 540
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam00618
      Location:106 → 189
      RasGEF_N; RasGEF N-terminal motif

    3. XM_021471710.1 → XP_021327385.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q1W3
      Conserved Domains (3) summary
      cd00153
      Location:677 → 763
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:259 → 541
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam00618
      Location:106 → 189
      RasGEF_N; RasGEF N-terminal motif

    4. XM_021471714.1 → XP_021327389.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PR95
      Conserved Domains (3) summary
      cd00153
      Location:674 → 760
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:259 → 540
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam00618
      Location:106 → 189
      RasGEF_N; RasGEF N-terminal motif

    5. XM_021471713.1 → XP_021327388.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PK82
      Conserved Domains (3) summary
      cd00153
      Location:675 → 761
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:259 → 541
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam00618
      Location:106 → 189
      RasGEF_N; RasGEF N-terminal motif

    6. XM_021471715.1 → XP_021327390.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M9Q1W7
      Conserved Domains (3) summary
      cd00153
      Location:629 → 715
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:211 → 493
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam00618
      Location:58 → 141
      RasGEF_N; RasGEF N-terminal motif

    7. XM_021471717.1 → XP_021327392.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9P940
      Conserved Domains (2) summary
      cd00153
      Location:268 → 354
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      cl02485
      Location:47 → 132
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    Nucleotide Protein
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