wdr26b WD repeat domain 26b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wdr26bprovided by ZNC
Official Full Name: WD repeat domain 26bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041014-277
See related: Ensembl:ENSDARG00000006812 AllianceGenome:ZFIN:ZDB-GENE-041014-277
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wdr26; fc89f06; fk83a10; wu:fc89f06; wu:fk83a10; si:ch211-153j24.6
Summary: Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in mitochondrion and nucleus. Predicted to be part of GID complex. Orthologous to human WDR26 (WD repeat domain 26). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (46699011..46734051)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (46795284..46830331)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Wdr26 induces anemia in zebrafish and enucleation defects in mouse erythroblasts because of impaired erythroblast nuclear condensation
Title: Wdr26 regulates nuclear condensation in developing erythroblasts.

Submit: New GeneRIF Correction

General gene information

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Markers

z3954 (e-PCR), detects polymorphism
- UniSTS:204830

fc89f06.x1 (e-PCR)
- UniSTS:188372

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GID complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: WD repeat-containing protein 26

Names: WD repeat domain 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001202442.1 → NP_001189371.1 WD repeat-containing protein 26

See identical proteins and their annotated locations for NP_001189371.1

Status: VALIDATED

Source sequence(s)

AL929435, BX004824

UniProtKB/Swiss-Prot

Q5SP67

Related

ENSDARP00000132796.1, ENSDART00000167398.2

Conserved Domains (4) summary

smart00668
Location:84 → 143

CTLH; C-terminal to LisH motif

COG2319
Location:258 → 553

WD40; WD40 repeat [General function prediction only]

cd00200
Location:261 → 553

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:270 → 311

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

46699011..46734051

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009294965.3 → XP_009293240.1 WD repeat-containing protein 26 isoform X2

See identical proteins and their annotated locations for XP_009293240.1

UniProtKB/Swiss-Prot

Q5SP67

Conserved Domains (4) summary

smart00668
Location:84 → 143

CTLH; C-terminal to LisH motif

COG2319
Location:258 → 553

WD40; WD40 repeat [General function prediction only]

cd00200
Location:261 → 553

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:270 → 311

7WD40; WD40 repeat [structural motif]
XM_021468480.1 → XP_021324155.1 WD repeat-containing protein 26 isoform X1

UniProtKB/TrEMBL

A0A8M9PSV3

Conserved Domains (3) summary

smart00668
Location:62 → 121

CTLH; C-terminal to LisH motif

cd00200
Location:239 → 531

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:248 → 289

7WD40; WD40 repeat [structural motif]