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    Cep135 centrosomal protein 135 [ Mus musculus (house mouse) ]

    Gene ID: 381644, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Cep135provided by MGI
    Official Full Name
    centrosomal protein 135provided by MGI
    Primary source
    MGI:MGI:2681869
    See related
    Ensembl:ENSMUSG00000036403 AllianceGenome:MGI:2681869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cep4; Gm1044
    Summary
    Predicted to enable protein C-terminus binding activity. Predicted to be involved in centrosome cycle; positive regulation of establishment of protein localization; and positive regulation of non-motile cilium assembly. Predicted to be located in centriole and centrosome. Is expressed in node. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 8. Orthologous to human CEP135 (centrosomal protein 135). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 3.6), liver E14 (RPKM 2.1) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cep135 in Genome Data Viewer
    Location:
    5 C3.3; 5 41.31 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (76736495..76794313)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (76588653..76646466)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene exocyst complex component 1 like Neighboring gene STARR-positive B cell enhancer ABC_E1053 Neighboring gene exocyst complex component 1 Neighboring gene capping protein inhibiting regulator of actin Neighboring gene predicted gene, 57768 Neighboring gene ribosomal protein L23a pseudogene Neighboring gene predicted gene, 34369

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation. Mizuno S, et al. Sci Rep, 2015 Sep 8. PMID 26346620, Free PMC Article
    2. Pitchfork regulates primary cilia disassembly and left-right asymmetry. Kinzel D, et al. Dev Cell, 2010 Jul 20. PMID 20643351, Free PMC Article
    3. Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Otto T, et al. Proc Natl Acad Sci U S A, 2017 Oct 3. PMID 28923932, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Centrosomal Protein CEP135 Regulates the Migration and Angiogenesis of Endothelial Cells in a Microtubule-Dependent Manner.
      Title: Centrosomal Protein CEP135 Regulates the Migration and Angiogenesis of Endothelial Cells in a Microtubule-Dependent Manner.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC86039

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole-centriole cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 135 kDa
    Names
    centrosomal protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199032.4 → NP_950197.1  centrosomal protein of 135 kDa

      See identical proteins and their annotated locations for NP_950197.1

      Status: VALIDATED

      Source sequence(s)
      AC127332
      Consensus CDS
      CCDS19365.1
      UniProtKB/Swiss-Prot
      Q6A030, Q6P5D4
      UniProtKB/TrEMBL
      Q3UVI6
      Related
      ENSMUSP00000112602.2, ENSMUST00000121979.8
      Conserved Domains (1) summary
      COG1196
      Location:199 → 934
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      76736495..76794313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535025.5 → XP_006535088.1  centrosomal protein of 135 kDa isoform X1

      UniProtKB/TrEMBL
      Q3UVI6
      Conserved Domains (3) summary
      COG1196
      Location:199 → 934
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:771 → 1121
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam13654
      Location:91 → 299
      AAA_32; AAA domain

    2. XM_036165238.1 → XP_036021131.1  centrosomal protein of 135 kDa isoform X3

      Conserved Domains (1) summary
      TIGR02168
      Location:2 → 739
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_006535028.4 → XP_006535091.1  centrosomal protein of 135 kDa isoform X4

      Conserved Domains (1) summary
      TIGR02168
      Location:1 → 676
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_006535027.3 → XP_006535090.1  centrosomal protein of 135 kDa isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:13 → 742
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_389278.5 RNA Sequence

    2. XR_004942529.1 RNA Sequence

    3. XR_004942530.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P5D4.1 GenPept UniProtKB/Swiss-Prot:Q6P5D4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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