Itgad integrin, alpha D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itgadprovided by MGI
Official Full Name: integrin, alpha Dprovided by MGI
Primary source: MGI:MGI:3578624
See related: Ensembl:ENSMUSG00000070369 AllianceGenome:MGI:3578624
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cd11d
Summary: Predicted to enable metal ion binding activity. Acts upstream of or within activated T cell proliferation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of integrin complex. Orthologous to human ITGAD (integrin subunit alpha D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 20.4), testis adult (RPKM 5.2) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 70.0 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (127773105..127822988)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (128173933..128205504)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Frontline Science: The expression of integrin alphaD beta2 (CD11d/CD18) on neutrophils orchestrates the defense mechanism against endotoxemia and sepsis.
Title: Frontline Science: The expression of integrin α(D) β(2) (CD11d/CD18) on neutrophils orchestrates the defense mechanism against endotoxemia and sepsis.
findings suggest that CD11d/CD18 upregulation on proinflammatory macrophages may represent a common mechanism for macrophage retention at inflammatory sites, thereby promoting chronic inflammation and disease development.
Title: The Upregulation of Integrin α(D)β(2) (CD11d/CD18) on Inflammatory Macrophages Promotes Macrophage Retention in Vascular Lesions and Development of Atherosclerosis.
The results indicate that both Mac-1 and alphaDbeta2 support macrophage fusion with Mac-1 playing a dominant role
Title: The Role of Integrins αMβ2 (Mac-1, CD11b/CD18) and αDβ2 (CD11d/CD18) in Macrophage Fusion.
Relative white adipose tissue (WAT) expression of CD11d was massively induced by obesity to an extent greater than any other inflammatory marker (to >300-fold of controls in the 45 and 60% fat groups) and this induction was WAT specific.
Title: Inflammatory phenotyping identifies CD11d as a gene markedly induced in white adipose tissue in obese rodents and women.
These studies identify previously unrecognized and unique activities of integrin alphaDbeta2, and macrophages that express it, in host defense and injury.
Title: Integrin alphaDbeta2 is dynamically expressed by inflamed macrophages and alters the natural history of lethal systemic infections.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Markers

RH124493 (e-PCR)
- UniSTS:161315

Cox6a2 (e-PCR), detects polymorphism
- UniSTS:508563

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin alpha-D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029872.3 → NP_001025043.3 integrin alpha-D precursor

See identical proteins and their annotated locations for NP_001025043.3

Status: VALIDATED

Source sequence(s)

AC124566, AW495405

Consensus CDS

CCDS21890.2

UniProtKB/TrEMBL

E9PXZ7, Q3U171

Related

ENSMUSP00000033051.10, ENSMUST00000033051.16

Conserved Domains (4) summary

smart00191
Location:559 → 614

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:156 → 367

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1165 → 1178

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:666 → 1003

Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

127773105..127822988

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153200.1 → XP_036009093.1 integrin alpha-D isoform X1

UniProtKB/TrEMBL

Q3U171

Conserved Domains (3) summary

smart00191
Location:559 → 614

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:156 → 367

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam08441
Location:666 → 1068

Integrin_alpha2; Integrin alpha
XM_006507971.3 → XP_006508034.1 integrin alpha-D isoform X2

UniProtKB/TrEMBL

Q3U171

Conserved Domains (4) summary

smart00191
Location:549 → 604

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:156 → 357

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1155 → 1168

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:656 → 1058

Integrin_alpha2; Integrin alpha
XM_006507972.3 → XP_006508035.1 integrin alpha-D isoform X3

UniProtKB/Swiss-Prot

Q3V0T4

UniProtKB/TrEMBL

H3BKX8

Related

ENSMUSP00000135572.2, ENSMUST00000177111.8

Conserved Domains (4) summary

smart00191
Location:523 → 578

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:156 → 331

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1129 → 1142

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:630 → 1032

Integrin_alpha2; Integrin alpha

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001177632.1: Suppressed sequence

Description

NM_001177632.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.