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    Lrrcc1 leucine rich repeat and coiled-coil centrosomal protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266808, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Lrrcc1provided by RGD
    Official Full Name
    leucine rich repeat and coiled-coil centrosomal protein 1provided by RGD
    Primary source
    RGD:628722
    See related
    Ensembl:ENSRNOG00000010891 AllianceGenome:RGD:628722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sap2
    Summary
    Predicted to be active in centrosome and cytoplasm. Orthologous to human LRRCC1 (leucine rich repeat and coiled-coil centrosomal protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 177.1), Kidney (RPKM 135.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrcc1 in Genome Data Viewer
    Location:
    2q23
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (88746904..88781532, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (87025671..87060313, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (88384796..88414012, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal biogenesis factor Neighboring gene transfer RNA proline (anticodon AGG) Neighboring gene E2F transcription factor 5 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 Neighboring gene solute carrier family 7 member 13, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Xiao HS, et al. Proc Natl Acad Sci U S A, 2002 Jun 11. PMID 12060780, Free PMC Article
    2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat and coiled-coil domain-containing protein 1
    Names
    leucine rich repeat and coiled-coil domain containing 1
    sodium channel associated protein 2, Sap2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100645.3 → NP_001094115.3  leucine-rich repeat and coiled-coil domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6ADQ1
      Conserved Domains (4) summary
      COG1196
      Location:639 → 1020
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00031
      Location:40 → 61
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:158 → 188
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:25 → 197
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      88746904..88781532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101805.2 → XP_038957733.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADQ1, A0A8I6AM64
      Related
      ENSRNOP00000090014.1
      Conserved Domains (4) summary
      COG0419
      Location:438 → 985
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      sd00031
      Location:40 → 61
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:158 → 188
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:25 → 197
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    2. XM_039101808.2 → XP_038957736.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ADQ1
      Conserved Domains (3) summary
      COG1196
      Location:558 → 939
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00031
      Location:25 → 50
      LRR_1; leucine-rich repeat [structural motif]
      cd21340
      Location:25 → 116
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    3. XM_039101810.2 → XP_038957738.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADQ1, E9PTY0
      Related
      ENSRNOP00000014762.7
      Conserved Domains (4) summary
      COG1196
      Location:624 → 1005
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00031
      Location:25 → 46
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:143 → 173
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:14 → 182
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    4. XM_039101811.2 → XP_038957739.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A6IH18
      Conserved Domains (1) summary
      COG1196
      Location:433 → 814
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_039101814.2 → XP_038957742.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A6IH18
      Conserved Domains (1) summary
      COG1196
      Location:267 → 648
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. XM_039101813.2 → XP_038957741.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X5

      Conserved Domains (4) summary
      COG1196
      Location:393 → 712
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00031
      Location:40 → 61
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:158 → 188
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:25 → 197
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    7. XM_039101815.2 → XP_038957743.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X7

      Conserved Domains (4) summary
      COG1196
      Location:410 → 525
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00031
      Location:40 → 61
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:158 → 188
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:25 → 197
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    Nucleotide Protein Strain
    Heading Accession and Version

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